CAMILA MALTA ROMANO
Projetos de Pesquisa
Unidades Organizacionais
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Phylogenetic analysis of complete genome sequences of hepatitis B virus from an Afro-Colombian community: presence of HBV F3/A1 recombinant strain(2012) ALVARADO-MORA, Monica V.; ROMANO, Camila M.; GOMES-GOUVEA, Michele S.; GUTIERREZ, Maria F.; CARRILHO, Flair J.; PINHO, Joao R. R.Background: Hepatitis B virus (HBV) infection is one of the most prevalent viral infections in humans and represents a serious public health problem. In Colombia, our group reported recently the presence of subgenotypes F3, A2 and genotype G in Bogota. The aim of this study was to characterize the HBV genotypes circulating in Quibdo, the largest Afro-descendant community in Colombia. Sixty HBsAg-positive samples were studied. A fragment of 1306 bp (S/POL) was amplified by nested PCR. Positive samples to S/POL fragment were submitted to PCR amplification of the HBV complete genome. Findings: The distribution of HBV genotypes was: A1 (52.17%), E (39.13%), D3 (4.3%) and F3/A1 (4.3%). An HBV recombinant strain subgenotype F3/A1 was found for the first time. Conclusions: This study is the first analysis of complete HBV genome sequences from Afro-Colombian population. It was found an important presence of HBV/A1 and HBV/E genotypes. A new recombinant strain of HBV genotype F3/A1 was reported in this population. This fact may be correlated with the introduction of these genotypes in the times of slavery.
conferenceObject Continuos excretion of JC virus and BK virus in one multiple sclerosis patient undergoing natalizumab treatment: one year follow up(2012) NALI, L. H. S.; SUMITA, L. M.; FINK, M. C. D.; OLIVAL, G. S.; SANTIAGO, T. F.; V, J. E. Bermudez; MORAES, L.; CAVENAGHI, V; TILBERY, C. P.; CALLEGARO, D.; CASSEB, J. S.; PENALVA-DE-OLIVEIRA, A. C.; ROMANO, C. M.conferenceObject Research of locus Xq22.3 as transcription source for endogenous retrovirus and its association with the multiple sclerosis etiology(2012) OLIVAL, G. S.; THOMAZ, R. B.; TILBERY, C.; FARIA, T. S.; NALI, L. S.; OLIVEIRA, A. C. Penalva de; CASSEB, J. S.; BERMUDEZ, J. V.; CAVENAGHI, V.; MORAES, L.; FINK, C.; SUMITA, L.; ROMANO, C. M.- Low Sensitivity of NS1 Protein Tests Evidenced during a Dengue Type 2 Virus Outbreak in Santos, Brazil, in 2010(2012) FELIX, Alvina Clara; ROMANO, Camila Malta; CENTRONE, Cristiane de Campos; RODRIGUES, Celia Lima; VILLAS-BOAS, Lucy; ARAUJO, Evaldo Stanislau; MATOS, Andreia Manso de; CARVALHO, Karina Inacio; MARTELLI, Celina Maria Turchi; KALLAS, Esper Georges; PANNUTI, Claudio Sergio; LEVI, Jose EduardoIn 2010, a large outbreak of dengue occurred in Santos, Brazil. The detection of the NS1 antigen was used for diagnosis in addition to the detection of IgG, IgM, and RNA. A large number of NS1 false-negative results were obtained. A total of 379 RNA-positive samples were selected for thorough evaluation. NS1 was reactive in 37.7% of cases. Most of the cases were characterized as a secondary infection by dengue 2 virus. Sequencing of NS1 positive and negative isolates did not reveal any mutation that could justify the diagnostic failure. Use of existing NS1 tests in the Brazilian population may present a low negative predictive value, and they should be used with caution, preferentially after performing a validation with samples freshly obtained during the ongoing epidemic.
conferenceObject New predictive markers for Natalizumab-associated progressive multifocal leukoencephalopaty, preliminary results(2012) OLIVAL, G. S.; NALI, L. H. S.; SIMM, R. F.; THOMAZ, R. B.; ROMANO, C. M.; MORAES, L.; FARIA, T. S.; CAVENAGHI, V. B.; SERAFIM, V.; APOSTOLOS, S.; SUMITA, L. S.; TILBERY, C. P.; BERMUDEZ, J. V.; CALLEGARO, D.; OLIVEIRA, A. C. Penalva de; FINK, C.conferenceObject Human herpesvirus in multiple sclerosis patients(2012) THOMAZ, R. B.; OLIVAL, G. S.; TILBERY, C. P.; BERMUDEZ, J. V.; NALI, L. H. S.; ROMANO, C. M.; MORAES, L.; CALLEGARO, D.; CAVENAGHI, V.; CASSEB, J. S.; OLIVEIRA, A. C. Penalva de; FINK, C.; SUMITA, L. S.