MARCELO HATANAKA

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina

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Autor: MORAES, Carlos G. De ×

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  • article 0 Citação(ões) na Scopus
  • article 20 Citação(ões) na Scopus
    Predictive Value of the Water Drinking Test and the Risk of Glaucomatous Visual Field Progression
    (2017) MORAES, Carlos G. De; SUSANNA JR., Remo; SAKATA, Lisandro M.; HATANAKA, Marcelo
    Purpose: The purpose of this is to test the hypothesis the intraocular pressure (IOP) peaks during a stress test [the water drinking test (WDT)] can estimate the risk of future visual field progression in treated primary open- angle glaucoma (POAG) patients. Patients and Methods: Design: Prospective, longitudinal study. Setting: Clinical practice. Study population: Treated POAG patients whose IOP was <= 18mmHg and who had no IOPlowering interventions between the date of the WDT and the last eligible visual field. Intervention: At baseline examination, patients underwent the WDT and were then followed at regular intervals with office-based IOP measurements and visual field testing. Main outcome measure: Cox-proportional hazards survival analysis testing the predictive value of IOP peaks during the WDT versus IOP measurements during office hours on visual field progression. Results: A total of 144 eyes of 96 patients with baseline visual field damage ranging from mild to severe followed for a mean of 28 months were analyzed. In the multivariable analysis adjusting for potential confounders, higher IOP peaks during the WDT were predictive of future visual field progression (hazard ratio=1.11; 95% confidence interval, 1.02 to 1.21; P= 0.013). The average and peak IOP during office hours over the same follow-up period were not significantly associated with progression (P= 0.651 and 0.569, respectively). Conclusions: IOP peaks detected with the WDT were predictive of future visual field progression in a treated POAG population. This stress test could be a useful tool for risk assessment in daily practice.
  • article 26 Citação(ões) na Scopus
    Reproducibility of intraocular pressure peak and fluctuation of the water-drinking test
    (2013) HATANAKA, Marcelo; ALENCAR, Luciana M.; MORAES, Carlos G. De; SUSANNA JR., Remo
    Background The water-drinking test has been used as a stress test to evaluate the drainage system of the eye. However, in order to be clinically applicable,a test must provide reproducible results with consistent measurements. This study was performed to verify the reproducibility of intraocular pressure peaks and fluctuation detected during the water-drinking test in patients with ocular hypertension and open-angle glaucoma. Design A prospective analysis of patients in a tertiary care unit for glaucoma treatment. Participants Twenty-four ocular hypertension and 64 open-angle glaucoma patients not under treatment. Methods The water-drinking test was performed in 2 consecutive days by the same examiners in patients not under treatment. Reproducibility was assessed using the intraclass correlation coefficient. Main Outcome Measures Peak and fluctuation of intraocular pressure obtained with the water-drinking test were analysed for reproducibility. Results Eighty-eight eyes from 24 ocular hypertension and 64 open-angle glaucoma patients not under treatment were evaluated. Test and retest intraocular pressure peak values were 28.38 +/- 4.64 and 28.38 +/- 4.56mmHg, respectively (P=1.00). Test and retest intraocular pressure fluctuation values were 5.75 +/- 3.9 and 4.99 +/- 2.7mmHg, respectively (P=0.06). Based on intraclass coefficient, reproducibility was excellent for peak intraocular pressure (intraclass correlation coefficient=0.79) and fair for intraocular pressure fluctuation (intraclass correlation coefficient=0.37). Conclusion Intraocular pressure peaks detected during the water-drinking test presented excellent reproducibility, whereas the reproducibility of fluctuation was considered fair.
  • article 9 Citação(ões) na Scopus
    Comparison of Intraocular Pressure Changes During the Water Drinking Test Between Different Fluid Volumes in Patients With Primary Open-angle Glaucoma
    (2018) SUSANNA, Carolina N.; SUSANNA JR., Remo; HATANAKA, Marcelo; SUSANNA, Bianca N.; SUSANNA, Fernanda N.; MORAES, Carlos G. De
    Purpose: The main objective of this study was to compare the intraocular pressure (IOP) response during the water drinking test (WDT) performed with 800 mL, 1000 mL, and 10 mL/kg of body weight and to test its relationship with body mass index (BMI). Methods: In this prospective, observer-masked, observational study, patients treated with primary open-angle glaucoma were evaluated. In group I, 29 consecutive patients with body weight <= 60 kg underwent an 800 mL fluid challenge followed by a second WDT session with 10 mL/kg of body weight no longer than 4 months apart. Group II included 30 consecutive patients with body weight > 60 kg who underwent a 1000 mL fluid challenge followed by an 800 L test no longer than 4 months apart. IOP was measured before (baseline) and after water ingestion every 15 minutes for 45 minutes. Results: In group I, there was no significant difference in baseline or peak IOP between 800 mL and 10 mL/kg of body weight tests (P = 0.12 and 0.56, respectively). However, 10 mL/kg tended to lead to consistently lower IOP values and a biased response in eyes with higher IOP. In group II, there was also no significant difference in baseline or peak IOP between 800 and 1000mL tests (P = 0.26 and 0.72, respectively). No biased response was observed in this group. There was no significant association between IOP peak and BMI with 800mL (P = 0.18), 10 mL/kg (P = 0.29), or 1000mL (P = 0.34). Conclusions: There was overall good agreement between WDT results with different fluid volumes. The response to the volume loads tested in this study was not influenced by the BMI.