SUELI MIEKO OBA SHINJO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Neurologia, Faculdade de Medicina
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
conferenceObject CD99 role in glioblastoma cell migration(2018) CARDOSO, Cavalca; LERARIO, Antonio Marcondes; BRANTIS, Carlos Eduardo de Carvalho; FREITAS, Vanessa Galdeno; SOARES, Roseli da Silva; MARIE, Suely Kazue Nagahashi; OBA-SHINJO, Sueli Mieko- Comparison between treatment naive juvenile and adult dermatomyositis muscle biopsies: difference of inflammatory cells phenotyping(2018) SHINJO, Samuel Katsuyuki; SALLUM, Adriana Maluf Elias; OBA-SHINJO, Sueli Mieko; SILVA, Marilda Guimaraes; SILVA, Clovis Artur; MARIE, Suely Kazue NagahashiBackground: Different inflammatory cells (i.e., CD4, CD8, CD20 and CD68) are involved in pathogenesis of DM muscle. In this context, the aim of this study was to assess and compare these inflammatory cell phenotyping in muscle samples of treatment naive juvenile and adult patients with dermatomyositis. Methods: This is a cross-sectional study, in which 28 untreated juvenile and 28 adult untreated dermatomyositis patients were included. Immunohistochemical analysis was performed on serial frozen muscle sections. Inflammatory cell phenotyping was analyzed quantitatively in endomysium, perimysium, and perivascular (endomysium and perimysium) area. Results: Mean age at disease onset was 73 and 42.0 years in juvenile and adult dermatomyositis, respectively. Both groups had comparable time duration from symptom's onset to biopsy performance. CD4 and CD8 positive cells distributions were similar in both groups in all analyzed area, except for more predominance of CD4 in perimysium at juvenile muscle biopsies. The CD20 and CD68 positive cells were predominantly observed in adult muscle biopsy sections, when compared to juvenile samples, except for similar distribution of CD20 in perivascular endomysium, and CD68 in perimysium. Conclusions: These data show that the differences between juvenile and adult dermatomyositis may be restricted not only to patients' age, but also to different inflammatory cell distribution, particularly, in new-onset disease. Further studies are necessary to confirm the present study data and to analyze meaning of the different inflammatory cell phenotyping distribution finding in these both diseases.
conferenceObject ADAM23 effects in proliferative and invasive phenotype of glioblastoma cells.(2018) JANDREY, Elisa Helena Farias; BARNABE, Gabriela Filoso; INOUE, Lilian Tiemi; ASPRINO, Paula Fontes; SANTOS, Natalia Cristina; SHINJO, Sueli Mieko Oba; MARIE, Suely Kazue Nagahashi; FURNARI, Frank; CAMARGO, Anamaria Aranha; COSTA, Erico TosoniconferenceObject Higher expression of lysyl oxidase family in GBM mesenchymal subtype and the clinical impact of LOXL3(2018) SOARES, Roseli Silva; LAURENTINO, Talita Sousa; MARIE, Suely Kazue Nagahashi; OBA-SHINJO, Sueli Mieko- Whole exome and RNA sequencing identify novel somatic mutations in gangliogliomas(2018) MARIE, Suely K.; OBA-SHINJO, Sueli M.; LERARIO, Antonio M.
conferenceObject Role of MELK, STMN1, and FANCC in human astrocytoma.(2018) SR., Fernanda Oliveira Serachi; SR., Sueli Mieko Oba Shinjo- A Brazilian family with inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia linked to the VCP pGly97Glu mutation(2018) SHINJO, Samuel Katsuyuki; OBA-SHINJO, Sueli Mieko; LERARIO, Antonio Marcondes; MARIE, Suely Kazue NagahashiThe objective of this study is to report a Brazilian patient and his family with inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD). A systematic review of the literature on the valosin-containing protein (VCP) mutation was also performed. The proband (patient) was initially treated as a case of possible refractory polymyositis with Paget's disease and later as an inclusion body myopathy. However, after admission to our service, and considering his personal and familial antecedents, whole exome sequencing was performed revealing valosin-containing protein (VCP) c.290G > A (p.Gly97Glu) mutation in the patient and his nine family members. The clinical presentation of the patient and his family was characterized by different degrees and evaluations of IBMPFD. According to the literature, only one family (Chinese) has this same VCP mutation concomitantly with different IBMPFD phenotype manifestations. The present study shows that IBMPFD should be considered as a differential diagnosis in patients with inflammatory myopathies associated to bone disease and/or cognitive impairment. Moreover, the study expands the genotypic spectrum of missense mutations of VCP gene in a Brazilian family with variable phenotypes.
- CD99 expression in astrocytomas and functional analysis in glioblastoma cell line(2018) CARDOSO, Lais Cavalca; MARIE, Suely Kazue; SOARES, Roseli Silva; OBA-SHINJO, Sueli M.