ALEXANDRE MENDONCA MUNHOZ
Índice h a partir de 2011
15
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/04 - Laboratório de Microcirurgia, Hospital das Clínicas, Faculdade de Medicina
LIM/04 - Laboratório de Microcirurgia, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Response to: Nano-Surface Implants: Indications and Limitations(2021) SFORZA, Marcos; BOTTI, Giovanni; HEDEN, Per; ZACHEDDU, Renato; MUNHOZ, Alexandre Mendonca; MAYO, Federico; KINNEY, Brian M.; HAMMOND, Dennis C.; CORDUFF, Niamh; MORELLI, Humberto Uribe; STAVROU, Demetris; CENTENO, Jesus
- The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans(2021) DOLOFF, Joshua C.; VEISEH, Omid; MEZERVILLE, Roberto de; SFORZA, Marcos; PERRY, Tracy Ann; HAUPT, Jennifer; JAMIEL, Morgan; CHAMBERS, Courtney; NASH, Amanda; AGHLARA-FOTOVAT, Samira; STELZEL, Jessica L.; BAUER, Stuart J.; NESHAT, Sarah Y.; HANCOCK, John; ROMERO, Natalia Araujo; HIDALGO, Yessica Elizondo; LEIVA, Isaac Mora; MUNHOZ, Alexandre Mendonca; BAYAT, Ardeshir; KINNEY, Brian M.; HODGES, H. Courtney; MIRANDA, Roberto N.; CLEMENS, Mark W.; LANGER, RobertSilicone is widely used in chronic implants and is generally perceived to be safe. However, textured breast implants have been associated with immune-related complications, including malignancies. Here, by examining for up to one year the foreign body response and capsular fibrosis triggered by miniaturized or full-scale clinically approved breast implants with different surface topography (average roughness, 0-90 mu m) placed in the mammary fat pads of mice or rabbits, respectively, we show that surface topography mediates immune responses to the implants. We also show that the surface surrounding human breast implants collected during revision surgeries also differentially alters the individual's immune responses to the implant. Moreover, miniaturized implants with an average roughness of 4 mu m can largely suppress the foreign body response and fibrosis (but not in T-cell-deficient mice), and that tissue surrounding these implants displayed higher levels of immunosuppressive FOXP3(+) regulatory T cells. Our findings suggest that, amongst the topographies investigated, implants with an average roughness of 4 mu m provoke the least amount of inflammation and foreign body response. The surface topography of breast implants mediates the immune responses to them, and implants with an average roughness of 4 mu m largely suppress foreign body response and fibrosis.
- Response to ""Clarification About 'Expert Consensus on the Use of a New Bioengineered, Cell-Friendly, Smooth Surface Breast Implant'""(2019) SFORZA, Marcos; HAMMOND, Dennis C.; BOTTI, Giovanni; HEDEN, Per; QUIROS, Manuel Chacon; MUNHOZ, Alexandre Mendonca; KINNEY, Brian M.; CORDUFF, Niamh
- Expert Consensus on the Use of a New Bioengineered, Cell-Friendly, Smooth Surface Breast Implant(2019) SFORZA, Marcos; HAMMOND, Dennis C.; BOTTI, Giovanni; HEDEN, Per; QUIROS, Manuel Chacon; MUNHOZ, Alexandre Mendonca; KINNEY, Brian M.; CORDUFF, NiamhBackground Although general guidelines are available for established silicone gel breast implants, the unique characteristics of the latest Motiva implants warrant specific guidelines. Objectives This study aimed to generate consensus recommendations and summarize expert-based advice to better understand current surgical practices and to establish guidelines for surgeons transitioning from other implant devices to the Motiva implants. Methods A survey was compiled by 12 plastic surgeon experts in aesthetic and reconstructive breast surgery and 1 biotechnology scientist, and distributed to 36 plastic surgeons to establish a consensus on the use of these devices. Surgical techniques, complication rates, and implant selection were among the topics discussed. Results The experts agreed on 3 core principles regarding the use of Motiva Round and Ergonomix implants. Firstly, the dissected pocket needs to be close fitting and steps must be taken to prevent expansion of the pocket. Secondly, implant selection must be individualized. Finally, surgical planning and technique must be carefully considered. When questioned about problems they had ecountered, 84.6% of the experts agreed that they experienced fewer overall complications and 76.9% confirmed reduced capsular contracture rates with these devices. Overall, 84.6% of the experts favored selecting Motiva Ergonomix implants over Round implants to achieve a more natural look. In addition, 92.3% of the experts agreed that Motiva implants, due to their innovative technology, reduce the risk of anaplastic large-cell lymphoma. Conclusions This international consensus of leading practitioners will assist plastic surgeons with patient selection, preoperative planning, and surgical technique. These recommendations are designed to optimize surgical outcomes, resulting in lower overall complication rates, more natural-looking breasts, and highly satisfied patients.