BENY LAFER
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Psiquiatria, Faculdade de Medicina - Docente
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Líder
14 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 14
conferenceObject Inflammatory factors (cytokines and cortisol) across different brain regions in bipolar disorder and their associations with neuropsychiatric symptoms: A post-mortem study(2020) NASCIMENTO, Camila; NUNES, Paula V.; SUEMOTO, Claudia K.; RODRIGUEZ, Roberta D.; LEITE, Renata E. P.; GRINBERG, Lea T.; PASQUALUCCI, Carlos A.; NITRINI, Ricardo; JACOB-FILHO, Wilson; BRENTANI, Helena P.; LAFER, Beny- Negative early life experiences as risk factors for suicidal behavior in bipolar disorders(2020) LAFER, Beny; OQUENDO, Maria A.
conferenceObject Structured physical exercise in bipolar depression: A pilot study(2020) DUARTE, Cicera; BELIZARIO, Gabriel O.; MATHIAS, Karla; SILVA, Michele; ROBERTO, Paulo; GREVE, Julia; LAFER, BenyconferenceObject Rehabilitating theory of mind in bipolar disorder: A randomized control study using metacognitive training(2020) ROTENBERG, Luisa de Siqueira; GOMES, Bernardo C.; LAFER, BenyconferenceObject Impaired social cognition in bipolar disorder: A meta-analysis of theory of mind in euthymic patients(2020) ROTENBERG, Luisa deSiqueira; BELIZARIO, Gabriel O.; BERALDI, Gabriel; LAFER, Beny- Psychological therapies and psychoeducational recommendations for bipolar disorder treatment during COVID-19 pandemic(2020) ROTENBERG, Luisa de Siqueira; NASCIMENTO, Camila; KHAFIF, Tatiana Cohab; DIAS, Rodrigo Silva; LAFER, Beny
- Emotion Regulation and Bipolar Disorder: Strategies during the COVID-19 Pandemic(2020) ROTENBERG, Luisa de Siqueira; KHAFIF, Tatiana Cohab; NASCIMENTO, Camila; LAFER, Beny
- Differences in the immune-inflammatory profiles of unipolar and bipolar depression(2020) BRUNONI, Andre R.; SUPASITTHUMRONG, Thitiporn; TEIXEIRA, Antonio Lucio; VIEIRA, Erica L. M.; GATTAZ, Wagner F.; BENSENOR, Isabela M.; LOTUFO, Paulo A.; LAFER, Beny; BERK, Michael; CARVALHO, Andre F.; MAES, MichaelBackground: Major depressive disorder (MDD) and bipolar depression (BD) both share increased immune-inflammatory activation. However, there are unclear patterns of differences in peripheral immune profiles between them. Methods: We examined such differences in 245 MDD and 59 BD patients, recruited in the same center, who were in an acute depressive episode of moderate severity. Hierarchical binary logistic regression analyses and generalized linear models were used to compare levels of plasma biomarkers between groups and to predict dichotomous classification. Results: Interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, soluble TNF receptor (sTNFR)1, IL-12 and IL-10 were significantly higher in MDD than in BD, whereas IL-6, sTNFR2, IL-18, IL-33, ST2 (IL1R Like 1) and KLOTHO were significantly higher in BD than in MDD. Moreover, logistic regression analyses correctly classified BD and MDD patients with 98.1% accuracy, using a combination of IL-6, IL-8, ST2, sTNFR2 (directly associated with BD) and IL-12 and TNF-alpha (directly associated with MDD). Patients with MDD with melancholic features showed higher IL-1 beta levels than those without melancholia. The sTNFR1 / sTNFR2 ratio significantly predicted MDD and state and trait anxiety and negative affect. Results remained significant after covariate adjustment, including drug use. Limitations: Cross-sectional study. Lack of control comparison group. Differences in exposure to medications among participants. Conclusions: Differences in immune profiles between BD and MDD patients exist, especially for the compensatory immune-regulatory system (CIRS): increased IL-10 is the primary immune-regulatory mechanism in MDD, while increased sTNFR2 and KLOTHO are the primary regulatory mechanisms in BD.
conferenceObject Emotion regulation in pediatric bipolar disorder: A rational for a review and meta-analysis(2020) KHAFIF, Tatiana; ROTENBERG, Luisa deSiqueira; NASCIMENTO, Camila; LAFER, BenyconferenceObject Disrupted Genes Modules in the Hippocampus of Older Adults With Bipolar Disorder(2020) NASCIMENTO, Camila; BARBOSA, Andre; NUNES, Paula; SUEMOTO, Claudia; LEITE, Renata; GRINBERG, Lea; PASQUALUCCI, Carlos; NITRINI, Ricardo; JACOB-FILHO, Wilson; BRENTANI, Helena; LAFER, Beny