BENY LAFER
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Psiquiatria, Faculdade de Medicina - Docente
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Líder
217 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 217
- Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group(2021) HAN, L. K. M.; DINGA, R.; HAHN, T.; CHING, C. R. K.; EYLER, L. T.; AFTANAS, L.; AGHAJANI, M.; ALEMAN, A.; BAUNE, B. T.; BERGER, K.; BRAK, I.; HENRY, C.; CASERAS, X.; CHAIM-AVANCINI, T. M.; ELVSåSHAGEN, T.; FAVRE, P.; FOLEY, S. F.; FULLERTON, J. M.; HOUENOU, J.; HOWELLS, F. M.; INGVAR, M.; COUVY-DUCHESNE, B.; KUPLICKI, R.; LAFER, B.; LANDéN, M.; FILHO, G. B.; MACHADO-VIEIRA, R.; MALT, U. F.; MCDONALD, C.; MITCHELL, P. B.; NABULSI, L.; OTADUY, M. C. G.; THOMPSON, P. M.; OVERS, B. J.; POLOSAN, M.; POMAROL-CLOTET, E.; RADUA, J.; CARBALLEDO, A.; RIVE, M. M.; ROBERTS, G.; RUHE, H. G.; SALVADOR, R.; Sarró S.; VELTMAN, D. J.; SATTERTHWAITE, T. D.; SAVITZ, J.; SCHENE, A. H.; SCHOFIELD, P. R.; SERPA, M. H.; CONNOLLY, C. G.; SIM, K.; SOEIRO-DE-SOUZA, M. G.; SUTHERLAND, A. N.; TEMMINGH, H. S.; PENNINX, B. W. J. H.; TIMMONS, G. M.; UHLMANN, A.; VIETA, E.; WOLF, D. H.; ZANETTI, M. V.; JAHANSHAD, N.; MARQUAND, A. F.; COLE, J. H.; SCHMAAL, L.; CULLEN, K. R.; DANNLOWSKI, U.; DAVEY, C. G.; OSIPOV, E.; DIMA, D.; DURAN, F. L. S.; ENNEKING, V.; FILIMONOVA, E.; FRENZEL, S.; FRODL, T.; FU, C. H. Y.; GODLEWSKA, B. R.; GOTLIB, I. H.; GRABE, H. J.; PORTELLA, M. J.; GROENEWOLD, N. A.; GROTEGERD, D.; GRUBER, O.; HALL, G. B.; HARRISON, B. J.; HATTON, S. N.; HERMESDORF, M.; HICKIE, I. B.; HO, T. C.; HOSTEN, N.; POZZI, E.; JANSEN, A.; KäHLER, C.; KIRCHER, T.; KLIMES-DOUGAN, B.; KRäMER, B.; KRUG, A.; LAGOPOULOS, J.; LEENINGS, R.; MACMASTER, F. P.; MACQUEEN, G.; RENEMAN, L.; MCINTOSH, A.; MCLELLAN, Q.; MCMAHON, K. L.; MEDLAND, S. E.; MUELLER, B. A.; MWANGI, B.; REPPLE, J.; ROSA, P. G. P.; SACCHET, M. D.; SäMANN, P. G.; SCHNELL, K.; SCHRANTEE, A.; GOIKOLEA, J. M.; SIMULIONYTE, E.; SOARES, J. C.; SOMMER, J.; STEIN, D. J.; STEINSTRäTER, O.; STRIKE, L. T.; THOMOPOULOS, S. I.; TOL, M.-J. van; VEER, I. M.; VERMEIREN, R. R. J. M.; HAARMAN, B. C. M.; WALTER, H.; WEE, N. J. A. van der; WERFF, S. J. A. van der; WHALLEY, H.; WINTER, N. R.; WITTFELD, K.; WRIGHT, M. J.; WU, M.-J.; VöLZKE, H.; YANG, T. T.; HAJEK, T.; ZANNIAS, V.; ZUBICARAY, G. I. de; ZUNTA-SOARES, G. B.; Abé C.; ALDA, M.; ANDREASSEN, O. A.; BøEN, E.; BONNIN, C. M.; CANALES-RODRIGUEZ, E. J.; CANNON, D.Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted “brain age” and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen’s d = 0.14, 95% CI: 0.08–0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates. © 2020, The Author(s).
- Emotion regulation in pediatric bipolar disorder: A meta-analysis of published studies(2021) KHAFIF, Tatiana Cohab; ROTENBERG, Luisa de Siqueira; NASCIMENTO, Camila; BERALDI, Gabriel Henrique; BIPOLAR, Beny LaferBackground: Emotion regulation is a relatively recent topic in psychiatry, and has only recently begun to be tested across Pediatric Bipolar Disorder (PBD). To date, no meta-analysis has investigated the presence of emotion regulation deficits in PBD patients. Objectives: The aim of this study is to understand where the literature stands on this topic, as well as how different researchers are measuring and grasping the concept of emotion regulation in pediatric bipolar disorders. Methods: A systematic search of trials using the terms (""Pediatric Bipolar Disorder"") AND (""Emotion Regulation"" OR ""Affect Regulation"" OR ""Mood Lability"" OR ""Mood Instability"" OR ""Irritability"") was conducted using PubMed, Google Scholar, ResearchGate, Web of Science and Psych Info databases. Of the initial 366 articles identified, 8 met eligibility criteria for the meta-analysis and were included in this study. Results: There is a statistically significant difference in Accuracy in Emotion Regulation tasks, with a tendency for lower accuracy in PBD patients; however, both groups did not differ statistically regarding Response Time. Conclusion: Our data suggests that PBD patients do present emotion regulation deficits, particularly regarding facial emotion recognition and affective language interference tasks mediated by cognitive assignments. These results have important implications in developing novel psychotherapeutic interventions for this population.
conferenceObject Late life depression in cases without dementia is associated to vascular lesions and Lewy Body pathology but not Alzheimer pathology in a large community sample neuropathological study(2019) NUNES, P. V.; SUEMOTO, C. K.; RODRIGUEZ, R. D.; FERRETTI-REBUSTINI, E. de Lucena; LEITE, R. E. P.; NASCIMENTO, F.; SALDANHA, N. M.; PASQUALUCCI, C. A.; NITRINI, R.; GRINBERG, L. T.; JACOB-FILHO, W.; LAFER, B.conferenceObject Gender differences in bipolar disorder evaluated by inductive logic programming approach(2013) DIAS, R. da Silva; SALVINI, R.; MADUREIRA, D. Q.; NERY, F. G.; SCIPPA, A. M.; MORENO, R. A.; KAPCZINSKI, F.; LAFER, B.Objective: Bipolar Disorder (BD) literature is not conclusive about gender differences, with sparse data about the association between the variables studied. The statistical analysis has limitations that prevent more complex correlational evaluation. The Inductive Logic Programming (ILP) is machine learning and pattern recognition computational approach with the ability to solve problems describing relations (rules) extracted from the data set mined. This is a pilot study with both analyses searching for rules exploring multi-relational association in BD gender differences. Methods: The demographic and clinical (108 variables) data from Brazilian Bipolar Research Network (183 men and 417 women) were compared initially through biostatistics techniques and with assessments of ILP (Aleph method) using two approaches: considering all variables and just statistic significant variables. The ILP performance (all rules together) was measured evaluating the contingence table considering true and false positive and negative cases and searching complementary variables beyond already founded in statistical analysis. Results: The biostatistics analysis showed no differences in socio-demographic characteristics. BD women were more likely to have depression and mixed states, while men more frequently presented mania as first mood episode. Women also showed higher rates of lifetime manic episodes, comorbidities with anxiety disorders, migraine, and hypothyroidism. BD men were more likely to present alcohol abuse or dependence and substance abuse or dependence. The ILP approach with all variables generated 93 rules (41 for men and 52 for women) and 89 rules considering just significant statistic variables (33 for men and 56 for women). The observed performance range to identify women and men were: accuracy 89.7% to 98.8%, balanced accuracy 82.9% to 99.1%; sensibility 65.9% to 98.2% and F-measure 79.4% to 99.1%. No range was observed for specificity and precision, both 100%. For both genders, the rules unrelated to significant statistically observed variables were different periods of: age of disease onset, age at diagnosis and age at start of treatment. Discussion: Gender differences founded in biostatistics analysis were in agreement with the literature. The ILP results obtained were complementary to biostatistics generating rules with high precision to identify gender in BD and described several associations between them elucidating the dynamicity of BD phenomenology and phenotypes opening space for a more thorough analysis. The rules generated by ILP were still sensitive to show the effect of age reflecting the influence of woman’s reproductive cycle.conferenceObject Predominant polarity as a potential moderator of cognitive-behavioral therapy response(2019) KHAFIF, T. C.; BELIZARIO, G. O.; ROTENBERG, L. deSiqueira; MORENO, L. G.; LAFER, B.; GOMES, B. C.conferenceObject Cognitive-behavioral rehabilitation vs treatment as usual for bipolar patients - a randomized controlled trial(2017) GOMES, B.; ROCCA, C. Castanho de Almeida; BELIZARIO, G. Okawa; GISELLE, C.; VALOIS, I.; FACHIN, R. de Vargas Penteado; FERNANDES, F.; LAFER, B.- Letter to the Editor(2017) SCORZA, Fulvio A.; MANSUR, Rodrigo B.; CERQUEIRA, Raphael O.; LAFER, Beny; KAPCZINSKI, Flavio; MCINTYRE, Roger S.; BRIETZKE, Elisa
- Parental age and the risk of bipolar disorder in the offspring: A systematic review and meta-analysis(2022) POLGA, Natalia; BARROS, Pedro Macul Ferreira de; FARHAT, Luis C.; ALMEIDA, Karla Mathias de; BLOCH, Michael H.; LAFER, BenyObjectives Whether parental age, i.e., paternal or maternal, at childbirth is associated with the risk of bipolar disorder (BD) in offspring remains unclear. We conducted a meta-analysis of observational studies to address this gap. Methods PubMed, PsycINFO, Embase, and Web of Science were searched up to June 2021. Studies investigating the associations between parental age at childbirth (exposure) and the risk of BD in offspring (outcome) were eligible for inclusion in our study. Paternal and maternal age were examined separately. Odds ratio (OR) was used as the effect size index. Data were pooled through random-effects meta-analyses. Results Seven studies involving 3,183,539 participants and 23,253 individuals with BD were included in our meta-analyses. Meta-analyses indicated an increased risk of BD in the offspring of the older paternal age groups (35-44 years old [k = 5; OR = 1.09; 95% CI 1.05, 1.14; p < 0.0001] and >= 45 years old [k = 5; OR = 1.44; 95% CI 1.19, 1.14; p = 0.0001]) in comparison with the reference category (25-34 years old). Meta-analysis also indicated an increased risk of BD in the offspring of the older maternal age group (>= 40 years old [k = 3; OR = 1.20; 95% CI 1.10, 1.31; p < 0.0001]) in comparison with the reference category (20-29 years old). Conclusions Advanced paternal and maternal age were both associated with an increased risk of BD in offspring. Further studies are needed to investigate the mechanisms behind this association.
- Cognitive effects of creatine monohydrate adjunctive therapy in patients with bipolar depression: Results from a randomized, double-blind, placebo-controlled trial(2017) TONIOLO, Ricardo Alexandre; FERNANDES, Francy de Brito Ferreira; SILVA, Michelle; DIAS, Rodrigo da Silva; LAFER, BenyBackground: Depressive episodes and cognitive impairment are major causes of morbidity and dysfunction in individuals suffering from bipolar disorder (BD). Novel treatment approaches that target clinical and cognitive aspects of bipolar depression are needed, and research on pathophysiology suggests that mitochondrial modulators such as the nutraceutical creatine monohydrate might have a therapeutic role for this condition. Methods: Eighteen (N=18) patients with bipolar depression according to DSM-IV criteria who were enrollled in a 6-week, randomized, double-blind, placebo-controlled trial of creatine monohydrate 6 g daily as adjunctive therapy were submitted to neuropsychological assessments (Wisconsin Card Sorting Test, Digit Span subtest of the Wechsler Adult Intelligence Scale-Third Edition, Stroop Color-Word Test, Rey-Osterrieth complex figure test, FAS Verbal Fluency Test) at baseline and week 6. Results: There was a statistically significant difference between the treatment groups of the change on the total scores after 6 weeks in the verbal fluency test, with improvement in the group receiving adjunctive treatment with creatine. We did not find significant differences between the groups of the changes on other neuropsychological tests. Limitations: Small sample and lack of a control group of healthy subjects. Conclusions: Our trial, which was the first to investigate the cognitive effects of creatine monohydrate on bipolar depression, indicates that supplementation with this nutraceutical for 6 weeks is associated with improvement in verbal fluency tests in patients with this condition.
- Association between solar insolation and a history of suicide attempts in bipolar I disorder(2019) BAUER, Michael; GLENN, Tasha; ALDA, Martin; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; AYHAN, Yavuz; BAETHGE, Christopher; BAUER, Rita; BAUNE, Bernhard T.; BECERRA-PALARS, Claudia; BELLIVIER, Frank; BELMAKER, Robert H.; BERK, Michael; BERSUDSKY, Yuly; BICAKCI, Sule; BIRABWA-OKETCHO, Harriet; BJELLA, Thomas D.; CABRERA, Jorge; CHEUNG, Eric Y. Wo; ZOMPO, Maria Del; DODD, Seetal; DONIX, Markus; ETAIN, Bruno; FAGIOLINI, Andrea; FOUNTOULAKIS, Kostas N.; FRYE, Mark A.; GONZALEZ-PINTO, Ana; GOTTLIEB, John F.; GROF, Paul; HARIMA, Hirohiko; HENRY, Chantal; ISOMETSA, Erkki T.; JANNO, Sven; KAPCZINSKI, Flavio; KARDELL, Mathias; KHALDI, Slim; KLIWICKI, Sebastian; KONIG, Barbara; KOT, Timur L.; KROGH, Rikke; KUNZ, Mauricio; LAFER, Beny; LANDEN, Mikael; LARSEN, Erik R.; LEWITZKA, Ute; LICHT, Rasmus W.; LOPEZ-JARAMILLO, Carlos; MACQUEEN, Glenda; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGOA, Monica; MELLE, Ingrid; MEZA-URZUA, Fatima; MING, Mok Yee; MONTEITH, Scott; MORKEN, Gunnar; MOSCA, Enrica; MOZZHEGOROVA, Anton A.; MUNOZ, Rodrigo; MYTHRI, Starlin V.; NACEF, Fethi; NADELLA, Ravi K.; NERY, Fabiano G.; NIELSEN, Rene E.; O'DONOVAN, Claire; OMRANI, Adel; OSHER, Yamima; SORENSEN, Helle Ostermark; OUALI, Uta; RUIZ, Yolanda Pica; PILHATSCH, Maximilian; PINNA, Marco; PONTE, Francisco D. R. da; QUIROZ, Danilo; RAMESAR, Raj; RASGON, Natalie; REDDY, M. S.; REIF, Andreas; RITTER, Philipp; RYBAKOWSKI, Janusz K.; SAGDUYU, Kemal; RAGHURAMAN, Bharathram Sathur; SCIPPA, Angela M.; SEVERUS, Emanuel; SIMHANDL, Christian; STACKHOUSE JR., Paul W.; STEIN, Dan J.; STREJILEVICH, Sergio; SUBRAMANIAM, Mythily; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TAGATA, Hiromi; TATEBAYASHI, Yoshitaka; TONDO, Leonardo; TORRENT, Carla; VAALER, Arne E.; VARES, Edgar; VEEH, Julia; VIETA, Eduard; VISWANATH, Biju; YOLDI-NEGRETE, Maria; ZETINA, Mark; ZGUEB, Yosra; WHYBROW, Peter C.In many international studies, rates of completed suicide and suicide attempts have a seasonal pattern that peaks in spring or summer. This exploratory study investigated the association between solar insolation and a history of suicide attempt in patients with bipolar I disorder. Solar insolation is the amount of electromagnetic energy from the Sun striking a surface area on Earth. Data were collected previously from 5536 patients with bipolar I disorder at 50 collection sites in 32 countries at a wide range of latitudes in both hemispheres. Suicide related data were available for 3365 patients from 310 onset locations in 51 countries. 1047 (31.1%) had a history of suicide attempt. There was a significant inverse association between a history of suicide attempt and the ratio of mean winter solar insolation/mean summer solar insolation. This ratio is smallest near the poles where the winter insolation is very small compared to the summer insolation. This ratio is largest near the equator where there is relatively little variation in the insolation over the year. Other variables in the model that were positively associated with suicide attempt were being female, a history of alcohol or substance abuse, and being in a younger birth cohort. Living in a country with a state-sponsored religion decreased the association. (All estimated coefficients p < 0.01). In summary, living in locations with large changes in solar insolation between winter and summer may be associated with increased suicide attempts in patients with bipolar disorder. Further investigation of the impacts of solar insolation on the course of bipolar disorder is needed.