NATASCHA CARDOSO DA FONSECA
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
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- Hippocampal serotonin depletion is related to the presence of generalized tonic-clonic seizures, but not to psychiatric disorders in patients with temporal lobe epilepsy(2015) FONSECA, Natascha C. da; JOAQUIM, Helena P. G.; TALIB, Leda L.; VINCENTIIS, Silvia de; GATTAZ, Wagner F.; VALENTE, Kette D.Objective: Previous studies suggest that concentration of serotonin ([5-HT]) plays a pathogenic role in various types of epilepsy inhibiting seizures. However, most have not considered the clinical variables of epilepsy, and all of these studies included small and heterogeneous samples with refractory epilepsy, regardless of etiology. In this work, we measured [5-HT]s in hippocampal tissues from a large series of patients with refractory temporal lobe epilepsy caused by hippocampal sclerosis who underwent epilepsy surgery and evaluated the relationship between [5HT] and epilepsy-related clinical variables and psychiatric disorders. Methods: We included 44 patients with refractory unilateral TLE-HS who underwent surgical treatment for epilepsy. Hippocampal samples were collected, and serotonin concentrations were measured with high-pressure liquid chromatography (HPLC). Results: Lower [5-HT]s were correlated with a history of GTC seizures (Student's t-test: p0.041). There were no differences in [5-HT]s according to the other clinical variables and the presence of psychiatric disorders. Significance: Our findings demonstrated that serotonin depletion in the hippocampus play an important role in some aspects of the severity of epilepsy (i.e., the presence of GTC seizures) in a homogeneous sample of patients with refractory temporal lobe epilepsy determined by hippocampal sclerosis, but not with the presence of psychiatric disorders.
bookPart Avaliação neurofisiológica(2018) VALENTE, Kette Dualibi Ramos; VINCENTIS, Silvia de; FONSECA, Natascha; PENTAGNA, Álvaro; HASAN, Rosa; TAVARES, Stella Marcia AzevedoconferenceObject Psychiatric Comorbidities In Patients With Temporal Lobe Epilepsy Are Not Related To 5-HT Transporter(2019) FONSECA, N. Cardoso da; VALENTE, K. Dualibi Ramos; JOAQUIM, H. Giroud; VICENTIIS, S. de; TALIB, L.; GATTAZ, W. FaridbookPart Avaliação neurofisiológica(2014) VALENTE, Kette Dualibi Ramos; VICENTIIS, Silvia de; FONSECA, Natascha; PENTAGNA, Álvaro; HASAN, Rosa; TAVARES, Stella Marcia Azevedo- 5-hydroxytryptamine1A receptor density in the hippocampus of patients with temporal lobe epilepsy is associated with disease duration(2017) FONSECA, N. C.; JOAQUIM, H. P. G.; TALIB, L. L.; VINCENTIIS, S.; GATTAZ, W. F.; VALENTE, K. D.Background and purpose: : To date, no study has evaluated the association between serotonin receptor density and clinical variables in patients with temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS) using hippocampal tissue. We evaluated 5-hydroxytryptamine1A receptor (5-HT1AR) density in hippocampal tissue from patients with TLE-HS. Methods: We analyzed the hippocampal tissue of 34 patients with pharmacoresistant unilateral TLE-HS. 5-HT1AR density was measured using semiquantitative western blotting. Results: There was an association between higher density of 5-HT1AR and longer duration of epilepsy (Spearman correlation: P = 0.040; generalized linear model: P = 0.026). Conclusions: This study demonstrated that hippocampal 5-HT1AR density is associated with epilepsy duration in patients with TLE-HS. The authors postulate that this may represent a potential regulatory enhancement of endogenous serotonergic neurotransmission in response to prolonged and enduring epileptiform activity in the hippocampal tissue of patients with pharmacoresistant TLE-HS.