FABIO EIJI ARIMURA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Clinical and epidemiological profile of patients with definite ocular sarcoidosis at a Brazilian referral center(2022) FERRACIOLI-ODA, Eduardo; KAWASSAKI, Alexandre de Melo; ARIMURA, Fabio Eiji; KAIRALLA, Ronaldo Adib; HIRATA, Carlos Eduardo; YAMAMOTO, Joyce Hisae
- Characterization and outcomes of pulmonary alveolar proteinosis in Brazil: a case series(2018) ATHAYDE, Rodolfo Augusto Bacelar de; ARIMURA, Fabio Eiji; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto Ribeiro; BALDI, Bruno GuedesObjective: Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by the alveolar accumulation of surfactant, which is composed of proteins and lipids. PAP is caused by a deficit of macrophage activity, for which the main treatment is whole-lung lavage (WLL). We report the experience at a referral center for PAP in Brazil. Methods: This was a retrospective study involving patients with PAP followed between 2002 and 2016. We analyzed information regarding clinical history, diagnostic methods, treatments, and outcomes, as well as data on lung function, survival, and complications. Results: We evaluated 12 patients (8 of whom were women). The mean age was 41 +/- 15 years. Most of the patients were diagnosed by means of BAL and transbronchial biopsy. The mean number of WLLs performed per patient was 2.8 +/- 2.5. One third of the patients never underwent WLL. Four patients (33.3%) had associated infections (cryptococcosis, in 2; nocardiosis, in 1; and tuberculosis, in 1), and 2 (16.6%) died: 1 due to lepidic adenocarcinoma and 1 due to complications during anesthesia prior to WLL. When we compared baseline data with those obtained at the end of the follow-up period, there were no significant differences in the functional data, although there was a trend toward an increase in SpO(2). The median follow-up period was 45 months (range, 1-184 months). The 5-year survival rate was 82%. Conclusions: To our knowledge, this is the largest case series of patients with PAP ever conducted in Brazil. The survival rate was similar to that found at other centers. For symptomatic, hypoxemic patients, the treatment of choice is still WLL. Precautions should be taken in order to avoid complications, especially opportunistic infections.
- Nephrobronchial fistula: a diagnostic challenge in a patient with IgG4-related disease(2023) PLENS, Glauco Cabral Marinho; BRIDI, Guilherme das Posses; NASCIMENTO, Ellen Caroline Toledo do; CHATE, Rodrigo Caruso; BALDI, Bruno Guedes; ARIMURA, Fabio Eiji; KAIRALLA, Ronaldo Adib
- Clinical, tomographic and functional comparison of sporadic and tuberous sclerosis complex-associated forms of lymphangioleiomyomatosis: a retrospective cohort study(2024) OLIVEIRA, Martina Rodrigues; WANDERLEY, Mark; FREITAS, Carolina Salim Goncalves; KAIRALLA, Ronaldo Adib; CHATE, Rodrigo Caruso; AMARAL, Alexandre Franco; ARIMURA, Fabio Eiji; SAMORANO, Luciana Paula; WATANABE, Elieser Hitoshi; CARVALHO, Carlos Roberto Ribeiro; BALDI, Bruno GuedesBackground Lymphangioleiomyomatosis (LAM) is a rare disease that can occur sporadically (S-LAM) or associated with the tuberous sclerosis complex (TSC-LAM). The natural history of LAM is not completely understood, including whether there is a difference between the clinical courses of the two forms. This study aimed to compare the clinical, functional and tomographic features between S-LAM and TSC-LAM, and evaluate the annual rates of change in lung function. Methods This retrospective cohort study included patients with LAM followed up between 1994 and 2019. Clinical, functional and imaging variables were evaluated, and the lung cysts were automatically quantified. Quality of life and predictors of lung function impairment were accessed, and the annual rate of lung function decline was compared between S-LAM and TSC-LAM. Results Of the 107 patients included, 77 had S-LAM and 30 had TSC-LAM. Although patients with TSCLAM had a higher prevalence of renal angiomyolipomas and neurological and dermatological manifestations, pulmonary function tests were similar. Patients with S-LAM had a greater rate of forced expiratory volume in 1 s decline and a higher extent of cysts. Pneumothorax, desaturation in the 6-minute walking test and a higher extent of lung cysts were predictors of functional impairment. A greater impact on vitality and emotional health was observed in the TSC-LAM. Conclusion Greater functional decline and a higher cystic extension were found in patients with S-LAM. Our study provides a broad clinical, functional and tomographic characterisation of patients with LAM, adding valuable information to the existing evidence to better understand the two forms of the disease.
- Rheumatoid arthritis-associated airway disease: longitudinal pulmonary function behavior(2024) SABBAG, Maria Laura Bertozo; MOLINA, Camila de Assis; SAWAMURA, Marcio Valente Yamada; BONFIGLIOLI, Karina; MEDEIROS-RIBEIRO, Ana Cristina; PUGLIESI, Alisson; NAKAGAWA, Renato Hideo; ARIMURA, Fabio Eiji; ATHANAZIO, Rodrigo Abensur; KAIRALLA, Ronaldo Adib; BALDI, Bruno Guedes; KAWANO-DOURADO, Leticia