LETICIA LESSA MANSUR
Projetos de Pesquisa
Unidades Organizacionais
LIM/34 - Laboratório de Ciências da Reabilitação, Hospital das Clínicas, Faculdade de Medicina
58 resultados
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- Performance of a sample of patients with Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD) and healthy elderly on a lexical decision test (LDT) as a measure of pre-morbid intelligence(2015) SERRAO, Valéria Trunkl; BRUCKI, Sônia Maria Dozzi; CAMPANHOLO, Kenia Repiso; MANSUR, Letícia Lessa; NITRINI, Ricardo; MIOTTO, Eliane CorreaObjective: The objective of this study was to describe the performance of healthy elderly patients with aging-related pathologies (MCI) and patients with AD on a lexical decision test. Methods: The study included 38 healthy elderly subjects, 61 MCI and 26 AD patients from the Neurology Department of the Hospital das Clinicas, Behavioral and Cognitive Neurology Group. The neuropsychological instruments included the episodic memory test (RAVLT), subtests from the WAIS-III (Matrix Reasoning and Vocabulary) to determine estimated IQ, the Boston naming test (BNT) and Lexical Decision Test (LDT).Results:All groups differed on the MMSE, as expected according to their pathologies, memory tests, naming and estimated IQ. For the vocabulary and the LDT - measures of crystalized intelligence no differences were found. Conclusion: The LDT demonstrated that lexical decision can be used as a measure of pre-morbid IQ among the individuals assessed in a Brazilian sample.
bookPart Avaliação neurolinguística do idoso(2014) MANSUR, Leticia Lessa; SCHOCHAT, Eliane; SILAGI, Marcela Lima; RABELO, Camila Maia- Nonpharmacological interventions for cognitive impairments following primary progressive aphasia: A systematic review of the literature(2013) CARTHERY-GOULART, Maria Teresa; SILVEIRA, Amanda da Costa da; MACHADO, Thais Helena; MANSUR, Leticia Lessa; PARENTE, Maria Alice de Mattos Pimenta; SENAHA, Mirna Lie Hosogi; BRUCKI, Sonia Maria Dozzi; NITRINI, RicardoABSTRACT This study provided a systematic review on nonpharmacological interventions applied to patients diagnosed with Primary Progressive Aphasia (PPA) and its variants: Semantic (SPPA), Nonfluent (NFPPA) and Logopenic (LPPA) to establish evidence-based recommendations for the clinical practice of cognitive rehabilitation for these patients. Methods: A PubMed and LILACS literature search with no time restriction was conducted with the keywords PPA (and its variants) AND rehabilitation OR training OR intervention OR therapy OR treatment OR effectiveness. To develop its evidence-based recommendations, a research committee identified questions to be addressed and determined the level of evidence for each study according to published criteria (Cicerone et al., 2000). Overall evidence for treatments was summarized and recommendations were derived. Results: Our search retrieved articles published from 1995 to 2013: 21 for SPPA, 8 for NFPPA, 3 for LPPA and 8 for PPA with no specification. Thirty-five studies were rated as Class III, consisting of studies with results obtained from one or more single-cases and that used appropriate single-subject methods with adequate quantification and analysis of results. The level of evidence of three functional interventions could not be established. One study was rated as Class II and consisted of a nonrandomized case-control investigation. Conclusion: Positive results were reported in all reviewed studies. However, in order to be recommended, some investigation regarding the intervention efficacy was required. Results of the present review allows for recommendation of some nonpharmacological interventions for cognitive deficits following PPA as Practice Options. Suggestions for further studies on PPA interventions and future research are discussed.
- Healthy Aging and Compensation of Sentence Comprehension Auditory Deficits(2015) SILAGI, Marcela Lima; RABELO, Camila Maia; SCHOCHAT, Eliane; MANSUR, Leticia LessaObjectives. To analyze the effect of aging on sentence auditory comprehension and to study the relationship between this language skill and cognitive functions (attention, working memory, and executive functions). Methods. A total of 90 healthy subjects were divided into three groups: adults (50-59 years), young-old (60-69 years), and old-old (70-80 years). Subjects were assessed using the Revised Token Test. The measures used for performance analysis were number of correct answers (accuracy) and execution time of commands on the different subtests. Results. Regarding accuracy, groups showed similar performance on the first blocks, but the young-old and old-old performed worse than adults on blocks 9 and 10. With respect to execution time, groups differed from block 2 (i.e., the groups differed for all blocks, except for block 1), with the worst performance observed in the old-old group, followed by that of the young-old group. Therefore, the elderly required more time to attain performance similar to that of adults, showing that time measurements are more sensitive for detecting the effects of age. Sentence comprehension ability is correlated with cognitive test performance, especially for global cognition and working memory tests. Conclusions. Healthy aging is characterized by the ability to compensate for difficulties in linguistic processing, which allows the elderly to maintain functional communication.
- Treatment of agrammatism in oral and written production in patients with Broca’s aphasia The use of implicit and explicit learning(2020) SILAGI, Marcela Lima; FERREIRA, Olavo Panseri; ALMEIDA, Isabel Junqueira de; SIMÕES, Janaina de Souza; ZAMPIERI, Sueli Aparecida; SANTANA, Beatriz Raz Franco de; MANSUR, Letícia LessaAbstract. Several approaches to the rehabilitation of agrammatism use implicit and explicit learning methods. Objective: To verify the effect of adapted Mapping Therapy and ORLA methods (explicit versus implicit learning) on the oral and written production in spontaneous language among agrammatic patients with Broca’s aphasia. Methods: Six individuals were submitted to Mapping Therapy and ORLA (Oral Reading for Language in Aphasia) treatments. Samples of oral and written production from a picture description task were compared pre and post-treatment. Results: In Mapping Therapy, the patients presented better performance after the training for the variables related to written production: number of words, nouns, verbs, closed-class words, and number of complete sentences. Regarding oral output, the patients had similar performance before and after the therapeutic process. In ORLA, the patients presented a significant difference before and after the therapeutic process in the variables related to oral production, increasing the number of words, number of verbs, and speech rate. There was no difference in pre and post-treatment performance in written production. Conclusion: Both implicit and explicit learning can be used in the treatment of agrammatism. Mapping Therapy was more effective for the treatment of agrammatism in written production, while ORLA was more effective for the agrammatism in oral production.
- Heterogeneity in semantic priming effect with a lexical decision task in patients after left hemisphere stroke(2016) HOLDERBAUM, Candice Steffen; MANSUR, Letícia Lessa; SALLES, Jerusa Fumagalli deABSTRACT Investigations on the semantic priming effect (SPE) in patients after left hemisphere (LH) lesions have shown disparities that may be explained by the variability in performance found among patients. The aim of the present study was to verify the existence of subgroups of patients after LH stroke by searching for dissociations between performance on the lexical decision task based on the semantic priming paradigm and performance on direct memory, semantic association and language tasks. All 17 patients with LH lesions after stroke (ten non-fluent aphasics and seven non aphasics) were analyzed individually. Results indicated the presence of three groups of patients according to SPE: one exhibiting SPE at both stimulus onset asynchronies (SOAs), one with SPE only at long SOA, and another, larger group with no SPE.
- Lexical-semantic processing in the semantic priming paradigm in aphasic patients(2012) SALLES, Jerusa Fumagalli de; HOLDERBAUM, Candice Steffen; PARENTE, Maria Alice Mattos Pimenta; MANSUR, Leticia Lessa; ANSALDO, Ana InesThere is evidence that the explicit lexical-semantic processing deficits which characterize aphasia may be observed in the absence of implicit semantic impairment. The aim of this article was to critically review the international literature on lexical-semantic processing in aphasia, as tested through the semantic priming paradigm. Specifically, this review focused on aphasia and lexical-semantic processing, the methodological strengths and weaknesses of the semantic paradigms used, and recent evidence from neuroimaging studies on lexical-semantic processing. Furthermore, evidence on dissociations between implicit and explicit lexical-semantic processing reported in the literature will be discussed and interpreted by referring to functional neuroimaging evidence from healthy populations. There is evidence that semantic priming effects can be found both in fluent and in non-fluent aphasias, and that these effects are related to an extensive network which includes the temporal lobe, the pre-frontal cortex, the left frontal gyrus, the left temporal gyrus and the cingulated cortex.
- Detecting mild cognitive impairment in narratives in Brazilian Portuguese: first steps towards a fully automated system(2018) TREVISO, Marcos Vinicius; SANTOS, Leandro Borges dos; SHULBY, Christopher; HUBNER, Lilian Cristine; MANSUR, Leticia Lessa; ALUISIO, Sandra MariaIn recent years, Mild Cognitive Impairment (MCI) has received a great deal of attention, as it may represent a pre-clinical state of Alzheimer's disease (AD). In the distinction between healthy elderly (CTL) and MCI patients, automated discourse analysis tools have been applied to narrative transcripts in English and in Brazilian Portuguese. However, the absence of sentence boundary segmentation in transcripts prevents the direct application of methods that rely on these marks for the correct use of tools, such as taggers and parsers. To our knowledge, there are only a few studies evaluating automatic sentence segmentation in transcripts of neuropsychological tests. The purpose of this study is to investigate the impact of the automatic sentence segmentation method DeepBond on nine syntactic complexity metrics extracted of transcripts of CTL and MCI patients.
- Inference comprehension from reading in individuals with mild cognitive impairment(2021) SILAGI, Marcela Lima; ROMERO, Vivian Urbanejo; OLIVEIRA, Maira Okada de; TRES, Eduardo Sturzeneker; BRUCKI, Sonia Maria Dozzi; RADANOVIC, Marcia; MANSUR, Leticia LessaInference comprehension is a complex ability that recruits distinct cognitive domains, such as language, memory, attention, and executive functions. Therefore, it might be sensitive to identify early deficits in subjects with MCI. To compare the performance of subjects with mild cognitive impairment (MCI) in an inference reading comprehension task, and to analyze the correlations between inferential comprehension and other cognitive functions. We studied 100 individuals aged 60 and over, divided into MCI (50) [aMCI (35), naMCI (15)], and cognitively healthy individuals [controls (50)]. The Implicit Management Test (IMT) was used to assess inference in reading comprehension in five categories: explicit, logical, distractor, pragmatic, and ""others"". MCI group performed worse than controls in logical, pragmatic, distractor, and ""others"" questions (p < 0.01). The aMCI and naMCI subgroups presented a similar performance in all types of questions (p > 0.05). We observed significant correlations between the total IMT score and the TMT-A in the naMCI group (r = - 0.562, p = 0.036), and the Rey-Osterrieth Complex Figure and RAVLT tasks in the aMCI group (r = 0.474, p = 0.010 and r = 0.593, p = 0.0001, respectively). The MCI group as a whole performed worse than controls on the logical, pragmatic, other and distractor questions, and consequently on the total score. There were no differences in explicit questions, which impose lower inferential demands. The aMCI group suffered a significant impact from memory on inference comprehension, and difficulties in executive functions impacted naMCI performance. The IMT was useful to differentiate MCI patients from cognitively healthy individuals, but not MCI subgroups among themselves.
- Language impairment in Huntington's disease(2012) AZAMBUJA, Mariana Jardim; RADANOVIC, Marcia; HADDAD, Monica Santoro; ADDA, Carla Cristina; BARBOSA, Egberto Reis; MANSUR, Leticia LessaLanguage alterations in Huntington's disease (HD) are reported, but their nature and correlation with other cognitive impairments are still under investigation. This study aimed to characterize the language disturbances in HD and to correlate them to motor and cognitive aspects of the disease. We studied 23 HD patients and 23 controls, matched for age and schooling, using the Boston Diagnostic Aphasia Examination, Boston Naming Test, the Token Test, Animal fluency, Action fluency, FAS-COWA, the Symbol Digit Modalities Test, the Stroop Test and the Hooper Visual Organization Test (HVOT). HD patients performed poorer in verbal fluency (p<0.0001), oral comprehension (p<0.0001), repetition (p<0.0001), oral agility (p<0.0001), reading comprehension (p=0.034) and narrative writing (p<0.0001). There was a moderate correlation between the Expressive Component and Language Competency Indexes and the HVOT (r=0.519, p=0.011 and r=0.450, p=0.031, respectively). Language alterations in HD seem to reflect a derangement in both frontostriatal and frontotemporal regions.