MONICA SANCHES YASSUDA
Projetos de Pesquisa
Unidades Organizacionais
EACH, EACH - Docente
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
71 resultados
Resultados de Busca
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- Normative data for the Brief Cognitive Screening Battery stratified by age and education(2017) YASSUDA, Mônica Sanches; SILVA, Henrique Salmazo da; LIMA-SILVA, Thais Bento; CACHIONI, Meire; FALCÃO, Deusivania Vieira da Silva; LOPES, Andrea; BATISTONI, Samila Sathler Tavares; NERI, Anita LiberalessoABSTRACT Introduction: Diagnosing neurocognitive disorders is challenging in low-educated individuals. Objective: To report normative data for the Brief Cognitive Screening Battery (BCSB) and to assess the association of age and education with performance on the BCSB in 240 community-dwelling elderly from Ermelino Matarazzo, São Paulo city. Methods: The inclusion criteria were scoring above the education-adjusted cut-off points on the Mini-Mental State Examination (MMSE) and below six points on the Geriatric Depression Scale (GDS). Results: Age was associated with performance on the Naming, Incidental Memory, Verbal Fluency, Clock Drawing Test, Delayed Recall and Recognition subtests. Education was associated with performance on Naming, Recognition, Verbal Fluency and the Clock Drawing Test. Conclusion: The normative values reported are relevant for diagnosing neurocognitive disorders in low-educated elderly.
- Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia(2017) CECCHINI, Mario Amore; YASSUDA, Monica Sanches; BAHIA, Valeria Santoro; SOUZA, Leonardo Cruz de; GUIMARAES, Henrique Cerqueira; CARAMELLI, Paulo; CARTHERY-GOULART, Maria Teresa; PATROCINIO, Flavia; FOSS, Maria Paula; TUMAS, Vitor; LIMA-SILVA, Thais Bento; BRUCKI, Sonia Maria Dozzi; NITRINI, Ricardo; SALA, Sergio Della; PARRA, Mario A.It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls. Participants were 32 cognitively intact adults, 35 individuals with AD and 18 with bvFTD. All patients were in the mild dementia stage. Receiver-operating characteristic (ROC) analyses were used to examine the diagnostic accuracy of the STMB. The results showed that AD patients performed significantly worse than controls and bvFTD patients in the STMB test, while the latter groups showed equivalent performance. The bound condition of the STMB test showed an AUC of 0.853, with 84.4% of sensitivity and 80% of specificity to discriminate AD from controls and an AUC of 0.794, with 72.2% of sensitivity and 80% of specificity to differentiate AD from bvFTD. Binding deficits seem specific to AD. The free recall version of the STMB test can be used for clinical purposes and may aid in the differential diagnosis of AD. Findings support the view that the STMB may be a suitable cognitive marker for AD.
- Addenbrooke's cognitive examination-revised: normative and accuracy data for seniors with heterogeneous educational level in Brazil(2017) CESAR, Karolina G.; YASSUDA, Monica S.; PORTO, Fabio H. G.; BRUCKI, Sonia M. D.; NITRINI, RicardoBackground:Several cognitive tools have been developed aiming to diagnose dementia. The cognitive battery Addenbrooke's Cognitive Examination - Revised (ACE-R) has been used to detect cognitive impairment; however, there are few studies including samples with low education. The aim of the study was to provide ACE-R norms for seniors within a lower education, including illiterates. An additional aim was to examine the accuracy of the ACE-R to detect dementia and cognitive impairment no dementia (CIND). Methods:Data originated from an epidemiological study conducted in the municipality of Tremembe, Brazil. The Brazilian version of ACE-R was applied as part of the cognitive assessment in all participants. Of the 630 participants, 385 were classified as cognitively normal (CN) and were included in the normative data set, 110 individuals were diagnosed with dementia, and 135 were classified as having CIND. Results:ACE-R norms were provided with the sample stratified into age and education bands. ACE-R total scores varied significantly according to age, education, and sex. To distinguish CN from dementia, a cut-off of 64 points was established (sensitivity 91%, specificity 76%) and to differentiate CN from CIND the best cut-off was 69 points (sensitivity 73%, specificity 65%). Cut-off scores varied according to the educational level. Conclusions:This study offers normative and accuracy parameters for seniors with lower education and it should expand the use of the ACE-R for this population segment.
conferenceObject Amyloid-beta Deposition, Brain Metabolism and Neuropsychological Profile in Elderly with Subjective Cognitive Decline and SuperAgers(2020) STUDART-NETO, Adalberto; COUTINHO, Artur; CARNEIRO, Camila de Godoi; MORAES, Natalia Cristina; SPERA, Raphael Ribeiro; YASSUDA, Monica Sanches; BRUCKI, Sonia Maria Dozzi; LEITE, Claudia; BUCHPIGUEL, Carlos; NITRINI, Ricardo- Multidisciplinary rehabilitation program: effects of a multimodal intervention for patients with Alzheimer's disease and cognitive impairment without dementia(2015) SANTOS, Glenda Dias; NUNES, Paula Villela; STELLA, Florindo; BRUM, Paula Schimidt; YASSUDA, Monica Sanches; UENO, Linda Massako; GATTAZ, Wagner Farid; FORLENZA, Orestes VicenteBackground: Non-pharmalogical interventions represent an important complement to standard pharmalogical treatment in dementia. Objective: This study aims to evaluate the effects of a multidisciplinary rehabilitation program on cognitive ability, quality of life and depression symptoms in patients with Alzheimer's disease (AD) and cognitive impairment without dementia (CIND). Methods: Ninety-seven older adults were recruited to the present study. Of these, 70 patients had mild AD and were allocated into experimental (n = 54) or control (n = 16) groups. Two additional active comparison groups were constituted with patients with moderate AD (n = 13) or with CIND (n = 14) who also received the intervention. The multidisciplinary rehabilitation program lasted for 12 weeks and was composed by sessions of memory training, recreational activities, verbal expression and writing, physical therapy and physical training, delivered in two weekly 6-hour sessions. Results: As compared to controls, mild AD patients who received the intervention had improvements in cognition (p = 0.021) and quality of life (p = 0.003), along with a reduction in depressive symptoms (p < 0.001). As compared to baseline, CIND patients displayed at the end of the intervention improvements in cognition (p = 0.005) and depressive symptoms (p = 0.011). No such benefits were found among patients with moderate AD. Discussion: This multidisciplinary rehabilitation program was beneficial for patients with mild AD and CIND. However, patients with moderate dementia did not benefit from the intervention.
- Relations between memory complaints, depressive symptoms and cognitive performance among community dwelling elderly(2014) SILVA, Lais dos Santos Vinholi E; SILVA, Thais Bento Lima da; FALCAO, Deusivania Vieira da Silva; BATISTONI, Samila Satler Tavares; LOPES, Andrea; CACHIONI, Meire; NERI, Anita Liberalesso; YASSUDA, Monica SanchesBackground: Memory complaints are quite common among the elderly; yet, the clinical relevance of these complaints to diagnose cognitive decline is debatable, since several different factors could be associated with them. Objective: The present paper examined the correlations between memory complaints, depressive symptoms and cognitive performance in a group of 301 elderly individuals who lived in the district of Ermelino Matarazzo, Sao Paulo, and who participated in the population-based survey entitled Profiles of Frailty in Elderly Brazilians by the FIBRA Network. Methods: Cognitive performance was assessed with the memorization test involving 10 common pictures, the Mini Mental State Examination (MMSE), the Verbal Fluency (VF) test, and the Clock Drawing Test, which comprise the Brief Cognitive Screening Battery (BCSB). Memory complaints were assessed with the Memory Complaint Questionnaire (MAC-Q), and depressive symptoms with the Geriatric Depression Scale (GDS). Results: Female participants had higher rates of memory complaints when compared to male participants (p = 0.013). Subjects with less years of schooling had more severe memory complaints and poorer cognitive performance than those with more years of schooling (p < 0.003). The presence of depressive symptoms was associated with poorer memory assessment scores (r = 0.39, p < 0.001). Discussion: Memory complaints were correlated with sex, schooling and depressive symptoms among elderly individuals residing in the community. No correlation was found between complaints and cognitive performance.
- Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization(2023) CRIVELLI, Lucia; CALANDRI, Ismael Luis; SUEMOTO, Claudia Kimie; SALINAS, Rosa Maria; VELILLA, Lina Marcela; YASSUDA, Monica Sanches; CARAMELLI, Paulo; LOPERA, Francisco; NITRINI, Ricardo; SEVLEVER, Gustavo Emilio; SOSA, Ana Luisa; ACOSTA, Daisy; BAIETTI, Ana Maria Charamelo; CUSICANQUI, Maria Isabel; CUSTODIO, Nilton; SIMONE, Sergio Dansilio De; DERIO, Carolina Delgado; DUQUE-PENAILILLO, Lissette; DURAN, Juan Carlos; JIMENEZ-VELAZQUEZ, Ivonne Z.; LEON-SALAS, Jorge Mario; BERGAMO, Yanina; CLARENS, Maria Florencia; DAMIAN, Andres; DEMEY, Ignacio; HELOU, Maria Belen; MARQUEZ, Carlos; MARTIN, Maria Eugenia; MARTIN, Maria da Graca Morais; QUERZE, Diego; SURACE, Ezequiel Ignacio; ACOSTA-EGEA, Sabrina; AGUIRRE-SALVADOR, Esteban; SOUZA, Leonardo Cruz de; CANCADO, Gustavo Henrique da Cunha Peixoto; BRUCKI, Sonia Maria Dozzi; FRIEDLAENDER, Clarisse Vasconcelos; GOMES, Karina Braga; GUTIERREZ, Myriam; RIOS, Carlos Laforcada; GALINDO, Joyce Graciela Martinez; MONTESINOS, Rosa; NUNEZ-HERRERA, Alberto; OSPINA-HENAO, Sebastian; RODRIGUEZ, Guillermina; MASSON, Victoria Ruiz; SANCHEZ, Monica; SCHENK, Christian E.; SOTO, Ligia; BARBOSA, Maira Tonidandel; TOSATTI, Jessica Abdo Goncalves; VICUNA, Yosselin; ESPELAND, Mark; HAKANSSON, Krister; KIVIPELTO, Miia; BAKER, Laura; SNYDER, Heather; CARRILLO, Maria; ALLEGRI, Ricardo FranciscoINTRODUCTION: Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America (LA). Our aim is to present the study design and discuss the strategies used for multicultural harmonization. METHODS: This 1-year RCT (working on a 1-year extension) investigates the feasibility of a multi-domain lifestyle intervention in LA and the efficacy of the intervention, primarily on cognitive function. An external harmonization process was carried out to follow the FINGER model, and an internal harmonization was performed to ensure this study was feasible and comparable across the 12 participating LA countries. RESULTS: Currently, 1549 participants have been screened, and 815 randomized. Participants are ethnically diverse (56% are Nestizo) and have high cardiovascular risk (39% have metabolic syndrome). DISCUSSION: LatAm-FINGERS overcame a significant challenge to combine the region's diversity into a multi-domain risk reduction intervention feasible across LA while preserving the original FINGER design.
- SOMATOFORM AND CONVERSION DISORDER PRECEDING LEWY BODY DEMENTIA: A NEWLY DESCRIBED PHENOMENOLOGICAL MANIFESTATION OF THE DISEASE(2015) APRAHAMIAN, Ivan; YASSUDA, Monica Sanches; MARTINELLI, Jose Eduardo
- Neuropsychiatric Symptoms, Caregiver Burden and Distress in Behavioral-Variant Frontotemporal Dementia and Alzheimer's Disease(2015) LIMA-SILVA, Thais Bento; BAHIA, Valeria Santoro; CARVALHO, Viviane Amaral; GUIMARAES, Henrique Cerqueira; CARAMELLI, Paulo; BALTHAZAR, Marcio Luiz; DAMASCENO, Benito; BOTTINO, Cassio Machado; BRUCKI, Sonia Maria; NITRINI, Ricardo; YASSUDA, Monica SanchesBackground/Aims: We aimed to compare caregiver burden and distress in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) and to investigate which factors contribute to caregivers' burden and distress. Methods: Fifty patients and their care-givers were invited to participate. Among the patients, 20 had a diagnosis of bvFTD and 30 had AD. Caregivers and patients were statistically equivalent for age, sex, education and dementia severity according to Clinical Dementia Rating. The protocol included the Short Zarit Burden Inventory, the Neuropsychiatric Inventory (NPI), Disability Assessment for Dementia (DAD), the Cornell Scale for Depression in Dementia (CSDD), Addenbrooke's Cognitive Examination-Revised, the Executive Interview with 25 Items, Direct Assessment of Functional Status and the Geriatric Anxiety Inventory (GAI). Results: In the NPI, caregivers of bvFTD patients reported a higher presence and severity of neuropsychiatric symptoms and caregiver distress compared to caregivers of AD patients. There was no significant difference in the perceived burden. In bvFTD, DAD and GAI scores were significantly correlated with burden, whereas in AD, burden was correlated with CSDD and NPI scores. Psychiatric symptoms were associated with distress in both groups. Conclusions: Caregivers of bvFTD patients experienced higher levels of distress than caregivers of AD patients. Patients' functional limitations were associated with burden of caregivers of bvFTD patients, whereas neuropsychiatric symptoms were associated with caregiver strain in both groups. (C) 2015 S. Karger AG, Basel
- Working memory training format in older adults: individual versus group sessions(2020) BRUM, Paula Schimidt; BORELLA, Erika; CARRETTI, Barbara; YASSUDA, Monica SanchesWorking memory (WM) training has been shown to increase the performance of participants in WM tasks and in other cognitive abilities, but there has been no study comparing directly the impact of training format (individual vs. group) using the same protocol. Therefore, the aim of this study was to compare the efficacy of the Borella et al. three session verbal WM training offered in two different formats on target and transfer tasks. This study was conducted in two waves. In the first wave, participants were randomized into individual training (n = 11) and individual control conditions (n = 15). In the second wave, participants were randomized into group training (n = 16) and group control conditions (n = 17). Training consisted of three sessions of WM exercises and participants in the active control condition responded to questionnaires during the same time. There was significant improvement for both training conditions at post-test and maintenance at follow-up for the target task, other WM tasks, processing speed, and executive functions tasks. The ANOVA results showed that the training gains did not depend on the WM training format. However, the effect size analyses suggested that this intervention can be more effective, at short term and follow-up, when provided individually. To conclude, this study showed that providing this training collectively or individually does not change the training benefits, which increases the possibilities of its use in different contexts.