MONICA SANCHES YASSUDA
Projetos de Pesquisa
Unidades Organizacionais
EACH, EACH - Docente
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
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- Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia(2017) CECCHINI, Mario Amore; YASSUDA, Monica Sanches; BAHIA, Valeria Santoro; SOUZA, Leonardo Cruz de; GUIMARAES, Henrique Cerqueira; CARAMELLI, Paulo; CARTHERY-GOULART, Maria Teresa; PATROCINIO, Flavia; FOSS, Maria Paula; TUMAS, Vitor; LIMA-SILVA, Thais Bento; BRUCKI, Sonia Maria Dozzi; NITRINI, Ricardo; SALA, Sergio Della; PARRA, Mario A.It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls. Participants were 32 cognitively intact adults, 35 individuals with AD and 18 with bvFTD. All patients were in the mild dementia stage. Receiver-operating characteristic (ROC) analyses were used to examine the diagnostic accuracy of the STMB. The results showed that AD patients performed significantly worse than controls and bvFTD patients in the STMB test, while the latter groups showed equivalent performance. The bound condition of the STMB test showed an AUC of 0.853, with 84.4% of sensitivity and 80% of specificity to discriminate AD from controls and an AUC of 0.794, with 72.2% of sensitivity and 80% of specificity to differentiate AD from bvFTD. Binding deficits seem specific to AD. The free recall version of the STMB test can be used for clinical purposes and may aid in the differential diagnosis of AD. Findings support the view that the STMB may be a suitable cognitive marker for AD.
- Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization(2023) CRIVELLI, Lucia; CALANDRI, Ismael Luis; SUEMOTO, Claudia Kimie; SALINAS, Rosa Maria; VELILLA, Lina Marcela; YASSUDA, Monica Sanches; CARAMELLI, Paulo; LOPERA, Francisco; NITRINI, Ricardo; SEVLEVER, Gustavo Emilio; SOSA, Ana Luisa; ACOSTA, Daisy; BAIETTI, Ana Maria Charamelo; CUSICANQUI, Maria Isabel; CUSTODIO, Nilton; SIMONE, Sergio Dansilio De; DERIO, Carolina Delgado; DUQUE-PENAILILLO, Lissette; DURAN, Juan Carlos; JIMENEZ-VELAZQUEZ, Ivonne Z.; LEON-SALAS, Jorge Mario; BERGAMO, Yanina; CLARENS, Maria Florencia; DAMIAN, Andres; DEMEY, Ignacio; HELOU, Maria Belen; MARQUEZ, Carlos; MARTIN, Maria Eugenia; MARTIN, Maria da Graca Morais; QUERZE, Diego; SURACE, Ezequiel Ignacio; ACOSTA-EGEA, Sabrina; AGUIRRE-SALVADOR, Esteban; SOUZA, Leonardo Cruz de; CANCADO, Gustavo Henrique da Cunha Peixoto; BRUCKI, Sonia Maria Dozzi; FRIEDLAENDER, Clarisse Vasconcelos; GOMES, Karina Braga; GUTIERREZ, Myriam; RIOS, Carlos Laforcada; GALINDO, Joyce Graciela Martinez; MONTESINOS, Rosa; NUNEZ-HERRERA, Alberto; OSPINA-HENAO, Sebastian; RODRIGUEZ, Guillermina; MASSON, Victoria Ruiz; SANCHEZ, Monica; SCHENK, Christian E.; SOTO, Ligia; BARBOSA, Maira Tonidandel; TOSATTI, Jessica Abdo Goncalves; VICUNA, Yosselin; ESPELAND, Mark; HAKANSSON, Krister; KIVIPELTO, Miia; BAKER, Laura; SNYDER, Heather; CARRILLO, Maria; ALLEGRI, Ricardo FranciscoINTRODUCTION: Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America (LA). Our aim is to present the study design and discuss the strategies used for multicultural harmonization. METHODS: This 1-year RCT (working on a 1-year extension) investigates the feasibility of a multi-domain lifestyle intervention in LA and the efficacy of the intervention, primarily on cognitive function. An external harmonization process was carried out to follow the FINGER model, and an internal harmonization was performed to ensure this study was feasible and comparable across the 12 participating LA countries. RESULTS: Currently, 1549 participants have been screened, and 815 randomized. Participants are ethnically diverse (56% are Nestizo) and have high cardiovascular risk (39% have metabolic syndrome). DISCUSSION: LatAm-FINGERS overcame a significant challenge to combine the region's diversity into a multi-domain risk reduction intervention feasible across LA while preserving the original FINGER design.
- Tackling dementia globally: the Global Dementia Prevention Program (GloDePP) collaboration(2019) CHAN, Kit Yee; ADELOYE, Davies; ASANTE, Kwaku Poku; CALIA, Clara; CAMPBELL, Harry; DANSO, Samuel O.; JUVEKAR, Sanjay; LUZ, Saturnino; MOHAN, Devi; MUNIZ-TERRERA, Graciela; NITRINI, Ricardo; NOROOZIAN, Maryam; NULKAR, Amit; NYAME, Solomon; PARALIKAR, Vasudeo; RODRIGUEZ, Mario A. Parra; POON, Adrienne N.; REIDPATH, Daniel D.; RUDAN, Igor; STEPHAN, Blossom C. M.; SU, TinTin; WANG, Huali; WATERMEYER, Tam; WILKINSON, Heather; YASSUDA, Monica Sanches; YU, Xin; RITCHIE, Craig
- Free Recall of Bound Information Held in Short-Term Memory is Unimpaired by Age and Education(2020) YASSUDA, Monica Sanches; CARTHERY-GOULART, Maria Teresa; CECCHINI, Mario Amore; CASSIMIRO, Luciana; FERNANDES, Katarina Duarte; BARADEL, Roberta Roque; GARCIA, Ricardo Basso; NITRINI, Ricardo; SALA, Sergio Della; PARRA, Mario AlfredoObjectives: It has been challenging to identify cognitive markers to differentiate healthy brain aging from neurodegeneration due to Alzheimer's disease (AD) that are not affected by age and education. The Short-Term Memory Binding (STMB) showed not to be affected by age or education when using the change detection paradigm. However, no previous study has tested the effect of age and education using the free recall paradigm of the STMB. Therefore, the objective of this study was to investigate age and education effects on the free recall version of the STMB test under different memory loads. Methods: 126 healthy volunteers completed the free recall STMB test. The sample was divided into five age bands and into five education bands for comparisons. The STMB test assessed free recall of two (or three) common objects and two (or three) primary colors presented as individual features (unbound) or integrated into unified objects (bound). Results: The binding condition and the larger set size generated lower free recall scores. Performance was lower in older and less educated participants. Critically, neither age nor education modified these effects when compared across experimental conditions (unbound v. bound features). Conclusions: Binding in short-term memory carries a cost in performance. Age and education do not affect such a binding cost within a memory recall paradigm. These findings suggest that this paradigm is a suitable cognitive marker to differentiate healthy brain aging from age-related disease such as AD.
- Profiles of cognitive impairment in the continuum from normal cognition to Alzheimer's clinical syndrome: Contributions of the short-term memory binding tests(2020) CECCHINI, Mario Amore; FOSS, Maria Paula; TUMAS, Vitor; PATROCINIO, Flavia A. P.; CHIARI-CORREIA, Rodolfo D.; NOVARETTI, Nathalia; BROZINGA, Tamara R.; BAHIA, Valeria Santoro; SOUZA, Leonardo Cruz de; GUIMARAES, Henrique Cerqueira; CARAMELLI, Paulo; LIMA-SILVA, Thais Bento; CASSIMIRO, Luciana; BRUCKI, Sonia Maria Dozzi; NITRINI, Ricardo; SALA, Sergio Della; PARRA, Mario A.; YASSUDA, Monica SanchesBackground Short-term memory binding (STMB) tests assess conjunctive binding, in which participants should remember the integration of features, such as shapes (or objects) and colors, forming a unique representation in memory. In this study, we investigated two STMB paradigms: change detection (CD) and free recall (FR). Objective To investigate the cognitive profile in the CD and FR tasks of three diagnostic groups: cognitively unimpaired (CU), mild cognitive impairment (MCI), and Alzheimer's clinical syndrome (ACS). In addition, we aimed to calculate and compare the accuracy of the CD and FR tasks to identify MCI and ACS. Methods Participants were 24 CU, 24 MCI, and 37 ACS. The cognitive scores of the clinical groups were compared using analysis of variance (ANOVA) and receiver-operating characteristic (ROC) analyses were carried out to verify the accuracy of the STMB tasks. Results In the CD task, CU was different from MCI and ACS (CU > MCI = ACS), while in the FR task all groups were different (CU > MCI > ACS). The ROC analyses showed an area under the curve (AUC) of 0.855 comparing CU with MCI for the CD task and 0.975 for the FR. The AUC comparing CU and ACS was 0.924 for the CD and 0.973 for the FR task. The FR task showed better accuracy to identify MCI patients, and the same accuracy to detect ACS. Conclusion The present findings indicate that impairments in CD and FR of bound representations are features of the cognitive profiles of MCI and ACS patients.