MELINA DE OLIVEIRA VALDO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- STENT FOR GRAFT VASCULAR DISEASE IN PEDIATRIC HEART TRANSPLANTATION: SINGLE CENTER EXPERIENCE(2013) SENAHA, Luciano Eiken; JATENE, Marcelo; FERNANDES, Marcos; SANTOS, Johnny Xavier; VALDO, Melinade Oliveira; NOBREGA, Pedro Thiago Brito de; DELGADO, Ana Beatriz Romani; MOURA, Mariana Tiemi Mine de; KAJITA, Luiz; AZEKA, EstelaOBJECTIVES: The aim of this study was to describe the need of stent for treatment of graft vascular disease in children submitted to hearttransplantation. MATERIAL AND METHODS: It was an observational study in a cohort of 115 patients who were submitted to heart transplantation at the Heart Institute (InCor) University of Sao Paulo Medical School. The data evaluated were: age, indication for transplantation, ischemic time and survival. RESULTS: From 1992 to 2012, 115 children were submitted to heart transplantation at our institution. There were 120 transplant procedures. Among these four had been submitted to percutaneus intervention for treatment of graft vascular disease. The mean age at time of the transplant was: 8.7 yrs. The period between the transplant and the stent procedure was from 1 to 8 yrs after the transplant. Three of these children died from 2 to 8 yrs after transplantation. CONCLUSION: Graft vascular disease is a severe complication after heart transplantation. Stent procedure can be an option, however other therapies need to be developed for this disease.
- Understanding yellow fever-associated myocardial injury: an autopsy study(2023) GIUGNI, Fernando Rabioglio; DEMARCHIAIELLO, Vera; FARIA, Caroline Silverio; POUR, Shahab Zaki; CUNHA, Marielton dos Passos; GIUGNI, Melina Valdo; PINESI, Henrique Trombini; LEDESMA, Felipe Lourenco; MORAIS, Carolina Esteves; HO, Yeh-Li; SZTAJNBOK, Jaques; FERNEZLIAN, Sandra de Morais; SILVA, Luiz Fernando Ferraz da; MAUAD, Thais; ALVES, Venancio Avancini Ferreira; SALDIVA, Paulo Hilario do Nascimento; ANTONANGELO, Leila; DOLHNIKOFF, Marisa; DUARTE-NETO, Amaro NunesBackground Yellow fever (YF) is a viral hemorrhagic fever, endemic in parts of South America and Africa. There is scarce evidence about the pathogenesis of the myocardial injury. The objective of this study is to evaluate the cardiac pathology in fatal cases of YF.Methods This retrospective autopsy study included cases from the Sao Paulo (Brazil) epidemic of 2017-2019. We reviewed medical records and performed cardiac tissue histopathological evaluation, electron microscopy, immunohistochemical assays, RT-qPCR for YF virus (YFV)-RNA, and proteomics analysis on inflammatory and endothelial biomarkers.Findings Seventy-three confirmed YF cases with a median age of 48 (34-60) years were included. We observed myocardial fibrosis in 68 (93.2%) patients; cardiomyocyte hypertrophy in 68 (93.2%); endothelial alterations in 67 (91.8%); fiber necrosis in 50 (68.5%); viral myocarditis in 9 (12.3%); and secondary myocarditis in 5 (6.8%). Four out of five patients with 17DD vaccine-associated viscerotropic disease presented with myocarditis. The cardiac conduction system showed edema, hemorrhages and endothelial fibrinoid necrosis. Immunohistochemistry detected CD68-positive inflammatory interstitial cells and YFV antigens in endothelial and inflammatory cells. YFV-RNA was detected positive in 95.7% of the cardiac samples. The proteomics analysis demonstrated that YF patients had higher levels of multiple inflammatory and endothelial biomarkers in comparison to cardiovascular controls, and higher levels of interferon gamma-induced protein 10 (IP-10) in comparison to sepsis (p = 0.01) and cardiovascular controls (p < 0.001) in Dunn test.Interpretation Myocardial injury is frequent in severe YF, due to multifactorial mechanisms, including direct YFV-mediated damage, endothelial cell injury, and inflammatory response, with a possible prominent role for IP-10.
- CONGENITAL HEART DISEASE IN ADOLESCENT AND ADULTS: INDICATION FOR HEART TRANSPLANTATION AND CLINICAL OUTCOME(2013) FARHAT, Juliana; JATENE, Marcelo; FERNANDES, Marcos; SENAHA, Luciano; DELGADO, Ana Beatriz Romani; TANAMATI, Carla; AIELLO, Vera; BENVENUTI, Luiz; PENHA, Juliano; VALDO, Melinade Oliveira; BRITO, Pedro Thiago; AZEKA, EstelaOBJECTIVE: The aim of the study was to evaluate the patients who were submitted to heart transplantation due to congenital heart disease. MATERIAL AND METHODS: It was considered a retrospective analysis of the medical records of the patients who were submitted to heart transplantation at Heart Institute (InCor) University of Sao Paulo Medical School from 2002 through 2012. RESULTS: From 2002 through 2012, 115 patients have undergone heart transplantation at Heart Institute (InCor) University of Sao Paulo Medical School. Of those, 29 (25.2%) had congenital heart diseases, having one of them submitted to re-transplantation 9 yrs after transplantation. The mean age was 8.56 yrs old (range of 0.11–26.06). The assessed congenital heart diseases were: double outlet (three patients), hypoplastic heart syndrome (two patients), pulmonary atresia (two patients), ventricular septal defect (one patient), Ebstein anomaly (two patients),Uhl anomaly (one patient), congenital heart block (three patients), tetralogy of Fallot (one patient), av canal (one patient), complex congenital heart disease (12 patients). Twenty patients had submitted to cardiac surgery before transplantation. The mean ischemia time was 170.8 min. Thirteen patients (44.8%) died (due to surgical complications, heart failure due to acute rejection and multiple organ insufficiency). Mean follow-up period of 4.7 yrs. CONCLUSION: Heart transplantation is an indication for patients with congenital heart disease and allowed long term survival for this population.
conferenceObject RELATIONSHIP BETWEEN ADMISSION TROPONIN AND OUTCOMES IN CRITICALLY ILL PATIENTS WITH HEART DISEASE AND COVID-19 IN A TERTIARY CENTER IN BRAZIL(2022) MOREIRA, Eduardo; PINESI, Henrique; VALDO, Melina; MARINS, Pedro Henrique; NASCIMENTO, Andre Luiz; ASSIS, Arthur; LIMA, Eduardo Gomes; PITTA, Fabio Grunspun; HAJJAR, Ludhmila; FERREIRA, Juliana; SERRANO JR., Carlos V.; GARZILLO, Cibele LarrosabookPart Biomarcadores cardiovasculares(2023) GIUGNI, Melina de Oliveira Valdo; GIUGNI, Fernando Rabioglio; PINESI, Henrique Trombini; PITTA, Fabio Grunspun