CHENG TZU YEN

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Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 5 de 5
  • article 57 Citação(ões) na Scopus
    Responses to Crizotinib Can Occur in High-Level MET-Amplified Non-Small Cell Lung Cancer Independent of MET Exon 14 Alterations
    (2017) CAPARICA, Rafael; YEN, Cheng Tzu; COUDRY, Renata; IGNATIUS, Sai-Hong; VARELLA-GARCIA, Marileila; CAMIDGE, D. Ross; CASTRO JR., Gilberto de
    Activation of the MET proto-oncogene (MET) highly sensitive to MET inhibition has recently been described in NSCLC through two mechanisms: high-level amplification of the MNNG HOS Transforming gene (MET) (usually expressed relative to the chromosome 7 centromere [CEP7] when using fluorescence in situ hybridization) and exon 14 alterations. As partial overlap of these biomarkers occurs, whether one is purely a surrogate for the other or both can represent true oncogenic driver states continues to be explored. Cases of MET inhibitor-sensitive NSCLC harboring exon 14 alterations without coincident amplification have already been described. Here we report two cases of MET inhibitor-sensitive NSCLC harboring high-level MET amplification (MET/CEP7 ratio >= 5) without coincident exon 14 alterations, suggesting that these two methods of MET activation can produce independent MET-addicted states in NSCLC. Molecular profiling designed to capture all cases of potentially MET-addicted NSCLC should address both activation mechanisms.
  • conferenceObject
    Characterization of EGFR Activating Mutations in Brazilian Patients with Pulmonary Adenocarcinoma
    (2015) YEN, Cheng T.; BITTON, Rafael C.; LIMA, Luiz G. C. A. De; AMADIO, Alex V.; TAKAHASHI, Tiago K.; MARINI, Andrea M.; TAKAGAKI, Tereza Y.; TERRA, Ricardo M.; MELLO, Evandro S.; CASTRO JR., Gilberto De
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    first-line cisplatin and irinotecan in advanced or metastatic gastric cancer
    (2015) CHENG, T. Y.; CORREA, T. Strava; ANDRADE, A. Maria Guimaraes M. C.; MUNIZ, D. Queiroz Borges; MESQUITA, M. Coelho; PEREIRA, G. Luiz Stelko; RIECHELMANN, R. Pimenta; HOFF, P. Marcelo Ghem
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    PRIMARY THORACIC ANGIOSARCOMA: TREATMENT AND OUTCOMES OF 5 PATIENTS
    (2013) SCARANTI, Mariana; YEN, Cheng T.; OLIVEIRA, Julia A. De; TOLOI, Diego A.; SIQUEIRA, Sheila A. C.; MARTINS, Renata E.; CAMARGO, Veridiana P. De; FEHER, Olavo; HOFF, Paulo M.; CASTRO JR., Gilberto
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    Validating ECOG Performance Status as a Prognostic Factor in Brazilian Patients with Pulmonary Adenocarcinoma
    (2015) BITTON, Rafael C.; LIMA, Luiz G. C. A. De; ROITBERG, Felipe S. R.; MESQUITA, Cristiane; MARTINS, Renata E.; YEN, Cheng T.; TERRA, Ricardo M.; MELLO, Evandro S.; CASTRO JR., Gilberto De