CAROLINA DE OLIVEIRA SOUZA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
15 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 15
conferenceObject Force platform analysis after deep brain stimulation of peduncolopontine nucleus in progressive supranuclear palsy: Report of one case(2015) SOUZA, C. O.; BRANT, R.; PARDINI, A. L.; BOARI, D.; TEIXEIRA, L. A.; TEIXEIRA, M. J.; BARBOSA, E. R.; FONOFF, E. T.- Peduncolopontine DBS improves balance in progressive supranuclear palsy: Instrumental analysis(2016) SOUZA, Carolina de Oliveira; LIMA-PARDINI, Andrea Cristina de; COELHO, Daniel Boari; MACHADO, Rachael Brant; ALHO, Eduardo Joaquim Lopes; ALHO, Ana Tereza Di Lorenzo; TEIXEIRA, Luis Augusto; TEIXEIRA, Manoel Jacobsen; BARBOSA, Egberto Reis; FONOFF, Erich Talamoni
- Relationship Between Posturography, Clinical Balance and Executive Function in Parkinson ' s Disease(2019) SOUZA, Carolina de Oliveira; VOOS, Mariana Callil; BARBOSA, Alessandra Ferreira; CHEN, Janini; FRANCATO, Debora Cristina Valente; MILOSEVIC, Matija; POPOVIC, Milos; FONOFF, Erich Talamoni; CHIEN, Hsin Fen; BARBOSA, Egberto ReisThis study aimed to evaluate the relationship between posturography, clinical balance, and executive function tests in Parkinson ' s disease (PD). Seventy-one people participated in the study. Static posturography evaluated the center of pressure fluctuations in quiet standing and dynamic posturography assessed sit-to-stand, tandem walk, and step over an obstacle. Functional balance was evaluated by Berg Balance Scale, MiniBESTest, and Timed Up and Go test. Executive function was assessed by Trail Making Test (TMT) and semantic verbal fluency test. Step over obstacle measures (percentage of body weight transfer and movement time) were moderately correlated to Timed Up and Go, part B of TMT and semantic verbal fluency (r > 0.40; p < 0.05 in all relationships). Stepping over an obstacle assesses the responses to internal perturbations. Participants with shorter movement times and higher percentage of body weight transfer (higher lift up index) on this task were also faster in Timed Up and Go, part B of TMT, and semantic verbal fluency. All these tasks require executive function (problem solving, sequencing, shifting attention), which is affected by PD and contribute to postural assessment.
conferenceObject Spinal cord stimulation improves freezing of gait in Parkinson's disease in chronic implanted stn-dbs patients: A case report(2016) SOUZA, C. O.; SOUZA, C. P.; PARDINI, A. L.; BOARI, D.; TEIXEIRA, L. A.; BARBOSA, E. R.; FONOFF, E. T.- Dramatic improvement of tardive dyskinesia movements by inline skating(2017) CASAGRANDE, Sara Carvalho Barbosa; CURY, Rubens Gisbert; LIMA-PARDINI, Andrea Cristina de; COELHO, Daniel Boari; SOUZA, Carolina de Oliveira; GHILARDI, Maria Gabriela dos Santos; SILVEIRA-MORIYAMA, Laura; TEIXEIRA, Luis Augusto; BARBOSA, Egberto Reis; FONOFF, Erich Talamoni
- Spinal cord stimulation improves gait in patients with Parkinson's disease previously treated with deep brain stimulation(2017) SOUZA, Carolina Pinto de; HAMANI, Clement; SOUZA, Carolina Oliveira; CONTRERAS, William Omar Lopez; GHILARDI, Maria Gabriela dos Santos; CURY, Rubens Gisbert; BARBOSA, Egberto Reis; TEIXEIRA, Manoel Jacobsen; FONOFF, Erich TalamoniBackgroundDeep brain stimulation and levodopatherapy ameliorate motor manifestations in Parkinson's disease, but their effects on axial signs are not sustained in the long term. ObjectivesThe objective of this study was to investigate the safety and efficacy of spinal cord stimulation on gait disturbance in advanced Parkinson's disease. MethodsA total of 4 Parkinson's disease patients who experienced significant postural instability and gait disturbance years after chronic subthalamic stimulation were treated with spinal cord stimulation at 300Hz. Timed-Up-GO and 20-meter-walk tests, UPDRS III, freezing of gait questionnaire, and quality-of-life scores were measured at 6 months and compared to baseline values. Blinded assessments to measure performance in the Timed-Up-GO and 20-meter-walk tests were carried out during sham stimulation at 300Hz and 60Hz. ResultsPatients treated with spinal cord stimulation had approximately 50% to 65% improvement in gait measurements and 35% to 45% in UPDRS III and quality-of-life scores. During blinded evaluations, significant improvements in the Timed-Up-GO and 20-meter-walk tests were only recorded at 300Hz. ConclusionSpinal cord stimulation at 300Hz was well tolerated and led to a significant improvement in gait. (c) 2016 International Parkinson and Movement Disorder Society.
- Effects of spinal cord stimulation on postural control in Parkinson's disease patients with freezing of gait(2018) LIMA-PARDINI, Andrea Cristina de; COELHO, Daniel Boari; SOUZA, Carolina Pinto; SOUZA, Carolina Oliveira; GHILARDI, Maria Gabriela dos Santos; GARCIA, Tiago; VOOS, Mariana; MILOSEVIC, Matija; HAMANI, Clement; TEIXEIRA, Luis Augusto; FONOFF, Erich TalamoniFreezing of gait (FoG) in Parkinson's disease (PD) is an incapacitating transient phenomenon, followed by continuous postural disorders. Spinal cord stimulation (SCS) is a promising intervention for FoG in patients with PD, however, its effects on distinct domains of postural control is not well known. The aim of this study is to assess the effects of SCS on FoG and distinct domains of postural control. Four patients with FoG were implanted with SCS systems in the upper thoracic spine. Anticipatory postural adjustment (APA), reactive postural responses, gait and FoG were biomechanically assessed. In general, the results showed that SCS improved FoG and APA. However, SCS failed to improve reactive postural responses. SCS seems to influence cortical motor circuits, involving the supplementary motor area. On the other hand, reactive posture control to external perturbation that mainly relies on neuronal circuitries involving the brainstem and spinal cord, is less influenced by SCS.
conferenceObject Quantitative evaluation of the effects of bilateral subthalamic deep brain stimulation (DBS) on balance in Parkinson's disease (PD)(2012) BRANT, R.; LUNA, N.; ANDRADE, D. C.; SOUZA, C.; GREVE, J.; FONOFF, E.; BARBOSA, E. R.conferenceObject Relation between educational status and motor scales (UPDRS-III, Berg Balance Scale and timed Up and Go Test) in individuals with Parkinson's disease(2012) SOUZA, C. O.; VOOS, M. C.; FONOFF, F. C.; VALENTE, D. F.; CHIEN, H. F.; FONOFF, E. T.; BARBOSA, E. R.conferenceObject The relationship between cognitive aspects (education status, executive function and verbal fluency) and motor aspects (balance and gait) in patients with Parkinson's disease(2016) SOUZA, C. O.; VOOS, M. C.; CHIEN, H. F.; FRANCATO, D. V.; BARBOSA, A. F.; GREVE, J. M.; FONOFF, E. T.; BARBOSA, E. R.