CAROLINA DE OLIVEIRA SOUZA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
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- Cognitive or Cognitive-Motor Executive Function Tasks? Evaluating Verbal Fluency Measures in People with Parkinson's Disease(2017) BARBOSA, Alessandra Ferreira; VOOS, Mariana Callil; CHEN, Janini; FRANCATO, Debora Cristina Valente; SOUZA, Carolina de Oliveira; BARBOSA, Egberto Reis; CHIEN, Hsin Fen; MANSUR, Leticia LessaIntroduction. Executive function deficits are observed in people with Parkinson's disease (PD) from early stages and have great impact on daily living activities. Verbal fluency and oral diadochokinesia involve phonarticulatory coordination, response inhibition, and phonological processing and may also be affected in people with PD. This study aimed to describe the performance of PD patients and an age-and education-matched control group on executive function, verbal fluency, and oral diadochokinesia tests and to investigate possible relationships between them. Methods. Forty people with PD and forty controls were evaluated with Trail Making Test (TMT, executive function) and phonemic/semantic verbal fluency and oral diadochokinesia (/pataka/) tests. Groups were compared by ANOVA and relationships were investigated by Pearson tests. Results. People with PD showed longer times in parts A and B of TMT. They also said fewer words in phonemic/semantic verbal fluency tests and less syllables in the diadochokinesia test. Oral diadochokinesia strongly correlated to parts A and B of TMT and to phonemic verbal fluency. Conclusion. Oral diadochokinesia was correlated to executive function and verbal fluency. The cognitive-motor interaction in verbal fluency and oral diadochokinesia must be considered not to overestimate the cognitive or motor impairments in people with PD.
- Dramatic improvement of tardive dyskinesia movements by inline skating(2017) CASAGRANDE, Sara Carvalho Barbosa; CURY, Rubens Gisbert; LIMA-PARDINI, Andrea Cristina de; COELHO, Daniel Boari; SOUZA, Carolina de Oliveira; GHILARDI, Maria Gabriela dos Santos; SILVEIRA-MORIYAMA, Laura; TEIXEIRA, Luis Augusto; BARBOSA, Egberto Reis; FONOFF, Erich Talamoni
- Spinal cord stimulation improves gait in patients with Parkinson's disease previously treated with deep brain stimulation(2017) SOUZA, Carolina Pinto de; HAMANI, Clement; SOUZA, Carolina Oliveira; CONTRERAS, William Omar Lopez; GHILARDI, Maria Gabriela dos Santos; CURY, Rubens Gisbert; BARBOSA, Egberto Reis; TEIXEIRA, Manoel Jacobsen; FONOFF, Erich TalamoniBackgroundDeep brain stimulation and levodopatherapy ameliorate motor manifestations in Parkinson's disease, but their effects on axial signs are not sustained in the long term. ObjectivesThe objective of this study was to investigate the safety and efficacy of spinal cord stimulation on gait disturbance in advanced Parkinson's disease. MethodsA total of 4 Parkinson's disease patients who experienced significant postural instability and gait disturbance years after chronic subthalamic stimulation were treated with spinal cord stimulation at 300Hz. Timed-Up-GO and 20-meter-walk tests, UPDRS III, freezing of gait questionnaire, and quality-of-life scores were measured at 6 months and compared to baseline values. Blinded assessments to measure performance in the Timed-Up-GO and 20-meter-walk tests were carried out during sham stimulation at 300Hz and 60Hz. ResultsPatients treated with spinal cord stimulation had approximately 50% to 65% improvement in gait measurements and 35% to 45% in UPDRS III and quality-of-life scores. During blinded evaluations, significant improvements in the Timed-Up-GO and 20-meter-walk tests were only recorded at 300Hz. ConclusionSpinal cord stimulation at 300Hz was well tolerated and led to a significant improvement in gait. (c) 2016 International Parkinson and Movement Disorder Society.
bookPart Parkinson´s disease(2017) CHIEN, Hsin Fen; BARBOSA, Egberto Reis; SOUZA, Carolina de Oliveira; DIAS, Alice Estevo; CONTI, Juliana- An fMRI-compatible force measurement system for the evaluation of the neural correlates of step initiation(2017) LIMA-PARDINI, Andrea Cristina de; AZEVEDO NETO, Raymundo Machado de; COELHO, Daniel Boari; BOFFINO, Catarina Costa; SHERGILL, Sukhwinder S.; SOUZA, Carolina de Oliveira; BRANT, Rachael; BARBOSA, Egberto Reis; CARDOSO, Ellison Fernando; TEIXEIRA, Luis Augusto; COHEN, Rajal G.; HORAK, Fay Bahling; AMARO JR., EdsonKnowledge of brain correlates of postural control is limited by the technical difficulties in performing controlled experiments with currently available neuroimaging methods. Here we present a system that allows the measurement of anticipatory postural adjustment of human legs to be synchronized with the acquisition of functional magnetic resonance imaging data. The device is composed of Magnetic Resonance Imaging (MRI) compatible force sensors able to measure the level of force applied by both feet. We tested the device in a group of healthy young subjects and a group of elderly subjects with Parkinson's disease using an event-related functional MRI (fMRI) experiment design. In both groups the postural behavior inside the magnetic resonance was correlated to the behavior during gait initiation outside the scanner. The system did not produce noticeable imaging artifacts in the data. Healthy young people showed brain activation patterns coherent with movement planning. Parkinson's disease patients demonstrated an altered pattern of activation within the motor circuitry. We concluded that this force measurement system is able to index both normal and abnormal preparation for gait initiation within an fMRI experiment.
bookPart Atypical parkinsonism(2017) BARSOTTINI, Orlando Graziani Povoas; SOUZA, Carolina de Oliveira; DIAFERIA, Giovana; ESPAY, Alberto J.