CAROLINA DE OLIVEIRA SOUZA

(Fonte: Lattes)
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina

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  • article 42 Citação(ões) na Scopus
    Effects of spinal cord stimulation on postural control in Parkinson's disease patients with freezing of gait
    (2018) LIMA-PARDINI, Andrea Cristina de; COELHO, Daniel Boari; SOUZA, Carolina Pinto; SOUZA, Carolina Oliveira; GHILARDI, Maria Gabriela dos Santos; GARCIA, Tiago; VOOS, Mariana; MILOSEVIC, Matija; HAMANI, Clement; TEIXEIRA, Luis Augusto; FONOFF, Erich Talamoni
    Freezing of gait (FoG) in Parkinson's disease (PD) is an incapacitating transient phenomenon, followed by continuous postural disorders. Spinal cord stimulation (SCS) is a promising intervention for FoG in patients with PD, however, its effects on distinct domains of postural control is not well known. The aim of this study is to assess the effects of SCS on FoG and distinct domains of postural control. Four patients with FoG were implanted with SCS systems in the upper thoracic spine. Anticipatory postural adjustment (APA), reactive postural responses, gait and FoG were biomechanically assessed. In general, the results showed that SCS improved FoG and APA. However, SCS failed to improve reactive postural responses. SCS seems to influence cortical motor circuits, involving the supplementary motor area. On the other hand, reactive posture control to external perturbation that mainly relies on neuronal circuitries involving the brainstem and spinal cord, is less influenced by SCS.