CAROLINA DE OLIVEIRA SOUZA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
20 resultados
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conferenceObject Force platform analysis after deep brain stimulation of peduncolopontine nucleus in progressive supranuclear palsy: Report of one case(2015) SOUZA, C. O.; BRANT, R.; PARDINI, A. L.; BOARI, D.; TEIXEIRA, L. A.; TEIXEIRA, M. J.; BARBOSA, E. R.; FONOFF, E. T.- Gait, posture and cognition in Parkinson's disease(2016) BARBOSA, Alessandra Ferreira; CHEN, Janini; FREITAG, Fernanda; VALENTE, Debora; SOUZA, Carolina de Oliveira; VOOS, Mariana Callil; CHIEN, Hsin FenABSTRACT Gait disorders and postural instability are the leading causes of falls and disability in Parkinson's disease (PD). Cognition plays an important role in postural control and may interfere with gait and posture assessment and treatment. It is important to recognize gait, posture and balance dysfunctions by choosing proper assessment tools for PD. Patients at higher risk of falling must be referred for rehabilitation as early as possible, because antiparkinsonian drugs and surgery do not improve gait and posture in PD.
- Peduncolopontine DBS improves balance in progressive supranuclear palsy: Instrumental analysis(2016) SOUZA, Carolina de Oliveira; LIMA-PARDINI, Andrea Cristina de; COELHO, Daniel Boari; MACHADO, Rachael Brant; ALHO, Eduardo Joaquim Lopes; ALHO, Ana Tereza Di Lorenzo; TEIXEIRA, Luis Augusto; TEIXEIRA, Manoel Jacobsen; BARBOSA, Egberto Reis; FONOFF, Erich Talamoni
conferenceObject Spinal cord stimulation improves freezing of gait in Parkinson's disease in chronic implanted stn-dbs patients: A case report(2016) SOUZA, C. O.; SOUZA, C. P.; PARDINI, A. L.; BOARI, D.; TEIXEIRA, L. A.; BARBOSA, E. R.; FONOFF, E. T.conferenceObject Executive function and verbal fluency in patients with Parkinson's disease(2016) BARBOSA, A. F.; VOOS, M. C.; SOUZA, C. O.; CHEN, J.; CHIEN, H. F.; FRANCATO, D. V.; BARBOSA, E. R.; MANSUR, L. L.- Non-invasive brain stimulation and kinesiotherapy for treatment of focal dystonia: Instrumental analysis of three cases(2020) SOUZA, Carolina de Oliveira; GOULARDINS, Juliana; COELHO, Daniel Boari; CASAGRANDE, Sara; CONTI, Juliana; LIMONGI, Joao Carlos Papaterra; BARBOSA, Egberto Reis; MONTE-SILVA, Katia; TANAKA, ClariceDystonia is a disabling movement disorder characterized by co-contraction of antagonist and agonist muscles, leading to abnormal sustained postures and impaired motor control. Cervical Dystonia (CD) and Hand Focal Dystonia (HFD) have been the most common forms of focal dystonia (FD). Do Non-Invasive Brain Neuromodulation (NIBS) such as Transcranial Direct Current Stimulation (tDCS) and repetitive Transcranial Magnetic Stimulation (rTMS) modulate the excitability of the connections between the motor cortical areas and may represent a therapeutic alternative for focal dystonia? Herein, we reported three cases of focal dystonia, two of them with cervical dystonia (CD) and one with hand focal dystonia (HFD), treated with NIBS combined to kinesiotherapy. The patients were daily submitted to 15 sessions of NIBS combined simultaneously with kinesiotherapy. CD patients were treated with tDCS (2 mA, 20 min, over the primary motor cortex), and HFD patient with rTMS (1 Hz, 1200 pulses, 80% of resting motor threshold, over the premotor cortex). For the CD patient's assessment, the Modified Toronto Scale for Cervical Dystonia Assessment (MTS), quiet balance test, and visual postural assessment were applied to observe the therapeutic effects. Quality handwriting analysis, tremor acceleration amplitudes, and the Wrinter's Cramp Rating Scale (WCRS) were used to assess the NIBS effect on HFD symptoms. Patients were evaluated before (pretest), immediately after (posttest), and three months after treatment (retention). NIBS associated with kinesiotherapy produced a long-term improvement of dystonia symptoms in all three patients. rTMS and tDCS associated with kinesiotherapy showed to be useful and safe to relief the dystonia symptoms in individuals with different types of focal dystonia with distinct functional disorders. Significance: The combined use of these intervention strategies seems to optimize and anticipate satisfactory clinical results in these neurological conditions, characterized by its difficult clinical management.
- Dramatic improvement of tardive dyskinesia movements by inline skating(2017) CASAGRANDE, Sara Carvalho Barbosa; CURY, Rubens Gisbert; LIMA-PARDINI, Andrea Cristina de; COELHO, Daniel Boari; SOUZA, Carolina de Oliveira; GHILARDI, Maria Gabriela dos Santos; SILVEIRA-MORIYAMA, Laura; TEIXEIRA, Luis Augusto; BARBOSA, Egberto Reis; FONOFF, Erich Talamoni
- Spinal cord stimulation improves gait in patients with Parkinson's disease previously treated with deep brain stimulation(2017) SOUZA, Carolina Pinto de; HAMANI, Clement; SOUZA, Carolina Oliveira; CONTRERAS, William Omar Lopez; GHILARDI, Maria Gabriela dos Santos; CURY, Rubens Gisbert; BARBOSA, Egberto Reis; TEIXEIRA, Manoel Jacobsen; FONOFF, Erich TalamoniBackgroundDeep brain stimulation and levodopatherapy ameliorate motor manifestations in Parkinson's disease, but their effects on axial signs are not sustained in the long term. ObjectivesThe objective of this study was to investigate the safety and efficacy of spinal cord stimulation on gait disturbance in advanced Parkinson's disease. MethodsA total of 4 Parkinson's disease patients who experienced significant postural instability and gait disturbance years after chronic subthalamic stimulation were treated with spinal cord stimulation at 300Hz. Timed-Up-GO and 20-meter-walk tests, UPDRS III, freezing of gait questionnaire, and quality-of-life scores were measured at 6 months and compared to baseline values. Blinded assessments to measure performance in the Timed-Up-GO and 20-meter-walk tests were carried out during sham stimulation at 300Hz and 60Hz. ResultsPatients treated with spinal cord stimulation had approximately 50% to 65% improvement in gait measurements and 35% to 45% in UPDRS III and quality-of-life scores. During blinded evaluations, significant improvements in the Timed-Up-GO and 20-meter-walk tests were only recorded at 300Hz. ConclusionSpinal cord stimulation at 300Hz was well tolerated and led to a significant improvement in gait. (c) 2016 International Parkinson and Movement Disorder Society.
conferenceObject Integrity of the superior longitudinal fascicle and its relationship with anticipatory postural adjustments in people with Parkinson's disease and freezing of gait(2016) LIMA-PARDINI, A. C. de; FREITAS, T. Q.; COELHO, D. B.; BOFFINO, C. C.; SOUZA, C.; BRANDT, R.; BARBOSA, E. R.; TEIXEIRA, L. A.; AMARO JR., E.conferenceObject Quantitative evaluation of the effects of bilateral subthalamic deep brain stimulation (DBS) on balance in Parkinson's disease (PD)(2012) BRANT, R.; LUNA, N.; ANDRADE, D. C.; SOUZA, C.; GREVE, J.; FONOFF, E.; BARBOSA, E. R.