FABIO BISCEGLI JATENE

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Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina - Líder

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Agora exibindo 1 - 10 de 19
  • article 0 Citação(ões) na Scopus
    Difference Between Cardiopulmonary Bypass Time and Aortic Cross-Clamping Time as a Predictor of Complications After Coronary Artery Bypass Grafting
    (2024) JUCA, Fabiano Goncalves; FREITAS, Fabiane Leticia de; GONCHAROV, Maxim; PES, Daniella de Lima; JUCA, Maria Eduarda Coimbra; DALLAN, Luis Roberto Palma; LISBOA, Luiz Augusto Ferreira; JATENE, Fabio B.; MEJIA, Omar Asdrubal Vilca
    Introduction: Along with cardiopulmonary bypass time, aortic cross -clamping time is directly related to the risk of complications after heart surgery. The influence of the time difference between cardiopulmonary bypass and cross -clamping times (TDC-C) remains poorly understood. Objective: To assess the impact of cardiopulmonary bypass time in relation to cross -clamping time on immediate results after coronary artery bypass grafting in the Registro Paulista de Cirurgia Cardiovascular (REPLICCAR) II. Methods: Analysis of 3,090 patients included in REPLICCAR II database was performed. The Society of Thoracic Surgeons outcomes were evaluated (mortality, kidney failure, deep wound infection, reoperation, cerebrovascular accident, and prolonged ventilation time). A cutoff point was adopted, from which the increase of this difference would affect each outcome. Results: After a cutoff point determination, all patients were divided into Group 1 (cardiopulmonarybypasstime <140 min.,TDC-C < 30 min.), Group 2 (cardiopulmonary bypass time < 140 min., TDC-C > 30 min.), Group 3 (cardiopulmonary bypass time > 140 min., TDC-C < 30 min.), and Group 4 (cardiopulmonary bypass time > 140 min., TDC-C > 30 min.). After univariate logistic regression, Group 2 showed significant association with reoperation (odds ratio: 1.64, 95% confidence interval: 1.01-2.66), stroke (odds ratio: 3.85, 95% confidence interval: 1.99-7.63), kidney failure (odds ratio: 1.90, 95% confidence interval: 1.32-2.74), and in -hospital mortality (odds ratio: 2.17, 95% confidence interval: 1.30-3.60). Conclusion: TDC-C serves as a predictive factor for complications following coronary artery bypass grafting. We strongly recommend that future studies incorporate this metric to improve the prediction of complications.
  • article
  • conferenceObject
    A New Allocation System for Priorization in Heart Transplantation in the State of Sao Paulo - Brazil: Its Impact on Patients in ECMO
    (2022) STEFFEN, Samuel P.; GAIOTTO, Fabio A.; GASPAR, Shyrline F.; SANTOS, Ronaldo Honorato B.; FILHO, Domingos D. L.; BACAL, Fernando; JATENE, Fabio B.
  • article 0 Citação(ões) na Scopus
    Coronary artery bypass grafting from splenic artery in Takayasu arteritis
    (2015) GARCIA, M. V. F.; CORDEIRO, R. A.; GAIOTTO, F. A.; JATENE, F. B.; SHINJO, S. K.; LEVY-NETO, M.
    The present report demonstrates that the splenic artery is an option as proximal blood source for saphenous vein grafts for surgical myocardial revascularization in Takayasu arterits (TA). This idiopathic vasculitis affects mainly aorta and its major branches including coronary arteries. A coronary artery bypass grafting (CABG) should be considered when coronary involvement occurs, although, calcification of the vessels affected often makes them unsuitable for use. We report the case of 56 years-old woman who presented unstable angina and multiple arterial involvement, with severe coronary lesions. The patient underwent a CABG with splenic artery as proximal blood source. After surgery, angina was resolved, with good exertional tolerance fora 2 years follow-up period. The surgical treatment of symptomatic TA was effective and safe, showing at complex surgeries without extracorporeal circulation may be greatly beneficial for that group of patients. Symptomatic improvement and excellent long-term graft patency should be expected after arterial reconstruction.
  • article 0 Citação(ões) na Scopus
    From Volume to Value Creation in Cardiac Surgery: What is Needed to Get off the Ground in Brazil?
    (2023) MEJIA, Omar Asdrubal Vilca; JATENE, Fabio Biscegli
  • article 3 Citação(ões) na Scopus
    MiRNA-30d and miR-770-5p as potential clinical risk predictors of Vasoplegic Syndrome in Patients undergoing on-pump coronary artery bypass grafting
    (2023) MEJIA, Omar Asdrubal Vilca; SOUZA, Renato Cesar de; SANTOS, Aritania S.; MENEGHINI, Bianca; SILVA, Ana Carolina Carvalho; BRASIL, Guilherme Visconde; RIGAUD, Vagner Oliveira Carvalho; DALLAN, Luis Roberto Palma; MOREIRA, Luiz Felipe Pinho; LISBOA, Luiz Augusto Ferreira; DALLAN, Luis Alberto Oliveira; KALIL, Jorge; CUNHA-NETO, Edecio; FERREIRA, Ludmila Rodrigues Pinto; JATENE, Fabio Biscegli
    The aims of this study were to perform pre-surgery miRNA profiling of patients who develop Vasoplegic syndrome (VS) after coronary artery bypass grafting (CABG) and identify those miRNAs that could be used as VS prognostic tools and biomarkers. The levels of 754 microRNAs (miRNAs) were measured in whole blood samples from a cohort of patients collected right before the coronary artery bypass grafting (CABG) surgery. We compared the miRNA levels of those who developed VS (VASO group) with those who did not (NONVASO group) after surgery. Six miRNAs (hsa-miR-548c-3p, -199b-5p, -383-5p -571 -183-3p, -30d-5p) were increased and two (hsa-1236-3p, and hsa-miR770-5p) were decreased in blood of VASO compared to NONVASO groups. Receiver Operating Characteristic (ROC) curve analysis revealed that a combination of the miRNAs, hsa-miR-30d-5p and hsa-miR-770-5p can be used as VS predictors (AUC = 0.9615, p < 0.0001). The computational and functional analyses were performed to gain insights into the potential role of these dysregulated miRNAs in VS and have identified the ""Apelin Liver Signaling Pathway"" as the canonical pathway containing the most target genes regulated by these miRNAs. The expression of the combined miRNAs hsa-miR-30d and hsa-miR-770-5p allowed the ability to distinguish between patients who could and could not develop VS, representing a potential predictive biomarker of VS.
  • article 0 Citação(ões) na Scopus
    Performance Evaluation of Geometrically Different Pediatric Arterial Cannulae in a Pediatric Cardiopulmonary Bypass Model
    (2024) CARVALHO, Gabriela B. de O.; CANEO, Luiz Fernando; MATTE, Gregory; CRUZ, Caio Henrique de A.; SILVA, Everton Neri da; CARLETTO, Luciana P.; CASTRO, Ana Vitoria C. X. de; SILVA, Betina G. Madueno; POLICARPO, Valeria C.; CESTARI, Idagene A.; JATENE, Fabio B.; JATENE, Marcelo Biscegli
    Objective: To define a reference chart comparing pressure drop vs. flow generated by a set of arterial cannulae currently utilized in cardiopulmonary bypass conditions in pediatric surgery.Methods: Cannulae from two manufacturers were selected considering their design and outer and inner diameters. Cannula performance was evaluated in terms of pressure drop vs. flow during simulated cardiopulmonary bypass conditions. The experimental circuits consisted of a Jostra HL-20 roller pump, a Quadrox-i pediatric oxygenator (Maquet Cardiopulmonary AG, Rastatt, Germany), and a custom pediatric tubing set. The circuit was primed with lactated Ringer's solution only (first condition) and with human packed red blood cells added (second condition) to achieve a hematocrit of 30%. Cannula sizes 8 to 16 Fr were inserted into the cardiopulmonary bypass circuit with a ""Y"" connector. The flow was adjusted in 100 ml/min increments within typical flow ranges for each cannula. Pre-cannula and post-cannula pressures were measured to calculate the pressure drop.Results: Utilizing a pressure drop limit of 100 mmHg, our results suggest a recommended flow limit of 500, 900, 1400, 2600, and 3100 mL/min for Braile arterial cannulae sizes 8, 10, 12, 14, and 16 Fr, respectively. For Medtronic DLP arterial cannulae sizes 8, 10, 12, 14, and 16 Fr, the recommended flow limit is 600, 1100, 1700, 2700, and 3300 mL/min, respectively.Conclusion:This study reinforces discrepancies in pressure drop between cannulae of the same diameter supplied by different manufacturers and the importance of independent translational research to evaluate components' performance.
  • article 23 Citação(ões) na Scopus
    Update of the Brazilian Guidelines for Valvular Heart Disease: An Approach to Anatomically Important Lesions Introduction
    (2017) TARASOUTCHI, Flavio; MONTERA, Marcelo Westerlund; RAMOS, Auristela Isabel de Oliveira; SAMPAIO, Roney Orismar; ROSA, Vitor Emer Egypto; DUENHASACCORSI, Tarso Augusto; LOPES, Antonio Sergio de Santis Andrade; FERNANDES, Joao Ricardo Cordeiro; PIRES, Lucas Jose Tachotti; SPINA, Guilherme Sobreira; VIEIRA, Marcelo Luiz Campos; LAVITOLA, Paulo de Lara; BIGNOTO, Tiago Costa; TOGNA, Dorival Julio Della; MESQUITA, Evandro Tinoco; ESTEVES, William Antonio de Magalhaes; ATIK, Fernando Antibas; COLAFRANCESCHI, Alexandre Siciliano; MOISES, Valdir Ambrosio; KIYOSE, Alberto Takeshi; POMERANTZEFF, Pablo Maria Alberto; LEMOS NETO, Pedro Alves; BRITO JUNIOR, Fabio Sandoli de; WEKSLER, Clara; BRANDAO, Carlos Manuel de Almeida; POFFO, Robinson; SIMOES, Ricardo; RASSI, Salvador; LEAES, Paulo Ernesto; ROCHA, Ricardo Mourilhe; PENA, Jose Luiz Barros; JATENE, Fabio Biscegli; BARBOSA, Marcia de Melo; SOUZA NETO, Joao David de; SARAIVA, Jose Francisco Kerr
  • conferenceObject
    CORONARY ARTERY BYPASS GRAFT SURGERY OUTCOMES IN PATIENTS WITH AND WITHOUTCOVID-19 DURING THE PANDEMIC FIRST WAVE
    (2023) MATUCK, Bruna Scarpa; PINESI, Henrique; MARTINS, Eduardo; GARZILLO, Cibele Larrosa; LOTTENBERG, Marcos Pita; LIMA, Joao A. C.; SEGRE, Alexandre; FAVARATO, Desiderio; LIMA, Eduardo Gomes; RACHED, Fabiana Hanna; PITTA, Fabio Grunspun; LISBOA, Luiz Augusto; JATENE, Fabio Biscegli; KALIL-FILHO, Roberto; SERRANO JR., Carlos V.
  • article 0 Citação(ões) na Scopus
    Financial Impact of Deep Sternal Wound Infections After Coronary Surgery: A Microcosting Analysis
    (2023) ORLANDI, Bianca Maria Maglia; MEJIA, Omar Asdrubal Vilca; TRINDADE, Evelinda Marramon; JATENE, Fabio B.
    Introduction: Deep sternal wound infections (DSWI) are so serious and costly that hospital services continue to strive to control and prevent these outcomes. Microcosting is the more accurate approach in economic healthcare evaluation, but there are no studies in this field applying this method to compare DSWI after isolated coronary artery bypass grafting (CABG). This study aims to evaluate the incremental risk-adjusted costs of DSWI on isolated CABG. Methods: This is a retrospective, single-center observational cohort study with a propensity score matching for infected and non-infected patients to compare incremental risk-adjusted costs between groups. Data to homogeneity sample was obtained from a multicentric database, REPLICCAR II, and additional sources of information about costs were achieved with the electronic hospital system (Si3). Inflation variation and dollar quotation in the study period were corrected using the General Market Price Index. Groups were compared using analysis of variance, and multiple linear regression was performed to evaluate the cost drivers related to the event. Results: As expected, infections were costly; deep infection increased the costs by 152% and mediastinitis by 188%. Groups differed among hospital stay, exams, medications, and multidisciplinary labor, and hospital stay costs were the most critical cost driver. Conclusion: In summary, our results demonstrate the incremental costs of a detailed microcosting evaluation of infections on CABG patients in Sao Paulo, Brazil. Hospital stay was an important cost driver identified, demonstrating the importance of evaluating patients'characteristics and managing risks for a faster, safer, and more effective discharge.