RONALDO ADIB KAIRALLA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
13 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 13
- Eosinophilic pneumonia: remember topical drugs as possible etiology(2018) DIAS, Olivia Meira; NASCIMENTO, Ellen Caroline Toledo do; CHATE, Rodrigo Caruso; KAIRALLA, Ronaldo Adib; BALDI, Bruno Guedes
- Immunohistological features related to functional impairment in lymphangioleiomyomatosis(2018) NASCIMENTO, Ellen Caroline Toledo do; BALDI, Bruno Guedes; MARIANI, Alessandro Wasum; ANNONI, Raquel; KAIRALLA, Ronaldo Adib; PIMENTA, Suzana Pinheiro; SILVA, Luiz Fernando Ferraz da; CARVALHO, Carlos Roberto Ribeiro; DOLHNIKOFF, MarisaBackground: Lymphangioleiomyomatosis (LAM) is a low-grade neoplasm characterized by the pulmonary infiltration of smooth muscle-like cells (LAM cells) and cystic destruction. Patients usually present with airway obstruction in pulmonary function tests (PFTs). Previous studies have shown correlations among histological parameters, lung function abnormalities and prognosis in LAM. We investigated the lung tissue expression of proteins related to the mTOR pathway, angiogenesis and enzymatic activity and its correlation with functional parameters in LAM patients. Methods: We analyzed morphological and functional parameters of thirty-three patients. Two groups of disease severity were identified according to FEV1 values. Lung tissue from open biopsies or lung transplants was immunostained for SMA, HMB-45, mTOR, VEGF-D, MMP-9 and D2-40. Density of cysts, density of nodules and protein expression were measured by image analysis and correlated with PFT parameters. Results: There was no difference in the expression of D2-40 between the more severe and the less severe groups. All other immunohistological parameters showed significantly higher values in the more severe group (p <= 0.002). The expression of VEGF-D, MMP-9 and mTOR in LAM cells was associated with the density of both cysts and nodules. The density of cysts and nodules as well as the expression of MMP-9 and VEGF-D were associated with the impairment of PFT parameters. Conclusions: Severe LAM represents an active phase of the disease with high expression of VEGF-D, mTOR, and MMP-9, as well as LAM cell infiltration. Our findings suggest that the tissue expression levels of VEGF-D and MMP-9 are important parameters associated with the loss of pulmonary function and could be considered as potential severity markers in open lung biopsies of LAM patients.
- Epipericardial fat necrosis: increasing the rate of diagnosis by disseminating knowledge within a single institution(2018) GIASSI, Karina de Souza; COSTA, André Nathan; KAIRALLA, Ronaldo Adib; PARGA FILHO, José Rodrigues
conferenceObject Antisynthetase Syndrome Interstitial Lung Disease Acute Exacerbation Due to Bacterial Infection: Case Report(2018) SOUZA, H. S. Pinto; ASSUNCAO, G. L.; OLIVEIRA FILHO, J. R. Bandeira de; VARGAS, L. Paez; COSTA, F. M. da; OLIVEIRA, M. Rodrigues de; ARIMURA, F. E.; AMARAL, A. F.; BALDI, B. G.; KAIRALLA, R. A.conferenceObject Survival Distinction in Interstitial Pneumonia with Autoimmune Features (IPAF) Patients: Results from a 5-Year Historical Cohort in an Interstitial Lung Diseases (ILD) Population(2018) PEREIRA, D. A.; BALDI, B. G.; CHULAM, C. S.; ARIMURA, F. E.; CARVALHO, C. R.; KAIRALLA, R. A.conferenceObject Respiratory Symptoms and Altered Physical Exam in Rheumatoid Arthritis Patients with Subclinical Interstitial Lung Abnormalities(2018) KAWANO-DOURADO, L.; SAWAMURA, M. V. Y.; BONFIGLIOLI, K.; ARIMURA, F. E.; LEE, H. J.; RANGEL, D. A. S.; CARVALHO, C. R. R.; DOYLE, T. J.; ROSAS, I. O.; KAIRALLA, R. A.conferenceObject Pulse Steroid Therapy to IPAF: A Case Report(2018) FILHO, R. B.; TAKIZAWA, D. B.; BEDER, T. N.; ARIMURA, F. E.; VARGAS, L. P.; COSTA, F. M. da; OLIVEIRA, M. R. de; BALDI, B. G.; KAIRALLA, R. A.conferenceObject A Case of Pancreatic and Splenic Involvement as the Main Presentation of Sarcoidosis(2018) SOUZA, H. S. Pinto; COSTA, F. Marques da; VARGAS, L. Paez; DOURADO, L. Kawano; BALDI, B. G.; KAIRALLA, R. A.conferenceObject Follicular Bronchiolitis Mimicking Mycobacterial Infection: Case Report(2018) PESSI, M. D.; OLIVEIRA, M. Rodrigues de; FILHO, R. B.; AMARAL, A. F.; ARIMURA, F. E.; SALES, R.; NASCIMENTO, E.; BALDI, B. G.; KAIRALLA, R. A.conferenceObject Response to Rituximab in Patients with Autoimmune Myopathies/Antisynthetase Syndrome and Interstitial Lung Disease: A Retrospective Cohort(2018) FILHO, R. B.; SOUZA, H. S. Pinto; BEDER, T. N.; SAWAMURA, M.; AMARAL, A. F.; SHINJO, S. K.; KAIRALLA, R. A.; BALDI, B. G.