ANA CRISTINA DE OLIVEIRA SOLIS

(Fonte: Lattes)
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5
Lattes
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Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina

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Revista / Livro: Brain Behavior and Immunity ×

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  • article 7 Citação(ões) na Scopus
    Evaluation of periodontitis in hospital outpatients with major depressive disorder. A focus on gingival and circulating cytokines
    (2016) SOLIS, Ana Cristina de Oliveira; MARQUES, Andrea Horvath; DOMINGUEZ, Wagner Vasques; PRADO, Euthymia Brandao de Almeida; PANNUTI, Claudio Mendes; LOTUFO, Roberto Fraga Moreira; LOTUFO-NETO, Francisco
    An imbalance in stimulated cytokine production is associated with the etiopathogenesis of numerous diseases such as major depressive disorder (MDD) and periodontal disease. Increased cytokine levels have been reported in the gingival crevicular fluid (GCF) of patients with MDD. Thirty-six outpatients with MDD participated in this study. Each outpatient was age-matched (+/- 3 years) with a healthy control (n = 36). The patients were controlled for race and smoking habits. Unstimulated and stimulated interleukin 6 (IL-6), interleukin 1 beta (IL-1 beta), and interferon-gamma (INF-gamma) production in whole blood culture (WBC) and IL-6 and IL-1 beta levels in the GCF were evaluated. Circulating levels of IL-6 and IL-1 beta (unstimulated) as well as GCF IL-1 beta were modestly lower in MDD patients, compared to the levels in age-matched controls (Mann-Whitney, p = 0.002, 0.0075, ANCOVA, p = 0.025, respectively). In the unstimulated group, there was no correlation between the levels of circulating IL-6 and GCF IL-6 (r = 0.07, p = 0.67), and between the levels of circulating IL-1 beta and the IL-1 beta level in the CGF (r = -0.08, p = 0.63). In the LPS stimulation group, there was no correlation between the levels of circulating levels of IL-6 and GCF IL-6 (r = 0.02, p= 0.91) or between the circulating IL-1 beta and GCF IL-1 beta (r = 0.13, p= 0.42). We observed modest immunosuppression in MDD patients (evaluated by no stimulation whole blood culture [WBC]), especially in patients with melancholic depression, chronic depression, and severe depression.