JOAO GLASBERG
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Agora exibindo 1 - 3 de 3
- Adjuvant chemotherapy in biliary tract cancer patients: A systematic review and meta-analysis of randomized controlled trials(2020) CAPARICA, Rafael; BRUZZONE, Marco; HACHEM, Georges El; CEPPI, Marcello; LAMBERTINI, Matteo; GLASBERG, Joao; AZAMBUJA, Evandro de; LAETHEM, Jean-Luc Van; HENDLISZ, AlainBackground: The role of adjuvant chemotherapy in biliary tract cancer is controversial. We performed a systematic review and meta-analysis to assess the effect of adjuvant chemotherapy in biliary tract cancer patients. Methods: A literature search was performed to identify randomized controlled trials (RCTs) comparing adjuvant chemotherapy versus observation, and a pooled analysis was conducted using the random-effect model. Results: Three RCTs (N = 866) were included. No difference was observed between chemotherapy and observation in terms of OS (HR 0.91; 95 %CI, 0.75-1.09; p = 0.295), whereas a significant improvement in RFS was shown (HR 0.83; 95 %CI, 0.69-0.99; p = 0.040). No subgroup that benefited most from adjuvant chemotherapy was identified, although a trend was observed in N+ patients (HR 0.83; 95 %CI, 0.65-1.08; p = 0.165). Discussion: Adjuvant chemotherapy yields a significant RFS benefit in biliary tract cancer patients and should be considered for those who are able to tolerate additional treatment after surgery.
conferenceObject Germline mutations in Brazilian pancreatic carcinoma patients.(2020) RODRIGUES, Livia Munhoz; MAISTRO, Simone; KATAYAMA, Maria Lucia Hirata; LEITE, Luiz A. Senna; GLASBERG, Joao; RIBEIRO, Ulysses; GUINDALINI, Rodrigo Santa Cruz; FOLGUEIRA, Maria A. A. KoikeconferenceObject METNET: A Phase II Trial of Metformin in Patients with Well Differentiated Neuroendocrine Tumors(2020) GLASBERG, J.; TALANS, A.; LOPEZ, R.; RECCHIMUZZI, D.; RIECHELMANN, R.