CARLOS WALTER SOBRADO JUNIOR
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
- Long-term real life efficacy of infliximab in Crohn's disease: Brazilian initial experience since 1999(2019) ARCEU, Scanavini Neto; NATALIA, Queiroz; MARCELO, Borba; CARLOS, Sobrado; MAGALY, Teixeira; EDESIO, Silva-Fillho; SERGIO, Nahas; IVAN, Cecconello
- Anoplastia com plicoma sentinela para o tratamento de fissura anal crônica.(2019) SOBRADO JÚNIOR, Carlos Walter; HORA, José Américo Bacchi; SOBRADO, Lucas Faraco; GUZELA, Vivian Regina; NAHAS, Sérgio Carlos; CECCONELLO, IvanABSTRACT Objective: to evaluate the long-term results of the correction of chronic anal fissures (CAF) in patients without anal hypertonia using the technique of anoplasty with skin tag flap. Methods: we conducted a prospective study of CAF patients refractory to conservative treatment without anal hypertonia, subjected to anoplasty with the use of anal plicoma to cover the bloody area. We confirmed the absence of anal hypertonia through rectal exam and electromanometry. We applied a visual pain questionnaire and the Cleveland Clinic fecal incontinence score before and after surgery. Results: we followed 15 patients with chronic anal fissure for a mean period of 29 months (12-56). The mean age was 41 years (29-69) and the duration of symptoms ranged from six months to five years. Healing occurred between three and six weeks for 13 patients (86.7%). The other two patients underwent debridement and new anoplasty successfully. No plicoma necrosis or anal stenosis occurred in any patient. The anal incontinence score did not change after the procedure, and all patients reported reduced pain. After 12 months of follow-up, none of the patients presented recurrence or anal incontinence, and 93.3% (14/15) of the patients were very satisfied. Conclusion: fissurectomy and anoplasty with the use of sentinel plie is a safe technique that results in improvement in pain without change of fecal continence and with high satisfaction rates.
conferenceObject Health-Related Quality of Life in Brazilian Adolescents and Young Adults (AYA) With Inflammatory Bowel Disease(2019) OBA, Jane; DEBONI, Mariana; TOMA, Ricardo; SOBRADO, Carlos; BORBA, Marcelo; AZEVEDO, Matheus; CARLOS, Alexandre; QUEIROZ, Natalia; DAMIAO, Aderson; CLOVIS, Artur Silva- Practical Aspects of Proactive TDM for Anti-TNF Agents in IBD: Defining Time Points and Thresholds to Target(2019) MARTINS, Camilla de Almeida; MOSS, Alan C.; SOBRADO, Carlos Walter; QUEIROZ, Natalia Sousa FreitasSerum biologic drug concentrations have been associated with favorable therapeutic outcomes in inflammatory bowel diseases, while low or undetectable drug levels have been linked to immunogenicity and treatment failure. Therapeutic drug monitoring (TDM) in the context of clinical relapse can guide decision making and is supported by professional groups. Proactive TDM consists of measurement of trough concentration with the goal of optimizing drug concentration in patients with clinical response/remission. Recent findings suggest that this approach can improve the efficacy of antitumor necrosis factor agents (anti-TNF). In this article, we summarize the rationale for proactive TDM for anti-TNF agents in practice, identify limitations in this evidence base, and provide practical advice for use in the clinic.
conferenceObject Ophthalmic Complications in Patients With Inflammatory Bowel Disease During Anti-TNF Treatment(2019) MILANI, Luciane; QUEIROZ, Natalia; AZEVEDO, Matheus; CARLOS, Alexandre; OBA, Jane; ROCHA, Beatriz; BARROS, Luisa; SOBRADO, Carlos; GONCALVES, Aline; LEITE, Andre; SIPAHI, Aytan; DAMIAO, AdersonconferenceObject Double Balloon Enteroscopy in Refractory Crohn's Disease: Jejunal Findings and Clinical Impact After 10 Years of Follow-Up(2019) FACANALI JR., Marcio; FACANALI, Carolina; QUEIROZ, Natalia; SOBRADO, Carlos; PRAZERES, Tulio; DEBONI, Mariana; FILHO, Edesio; OBA, Jane; TOMA, Ricardo; NAHAS, Sergio; RIBEIRO, Adriana SaflatleconferenceObject Takayasu's Arteritis and Inflammatory Bowel Diseases: Different Immune-Mediated Disorders or a Rare Extra-Intestinal Manifestation?: Case Series and Literature Review(2019) FACANALI, Carolina; SOBRADO, Carlos; QUEIROZ, Natalia; PEREIRA, Rosa Maria; NETO, Arceu Scanavini; BORBA, Marcelo; FACANALI JR., Marcio; NAHAS, Sergio; IVAN, Cecconello