HERALDO POSSOLO DE SOUZA

(Fonte: Lattes)
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Lattes
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Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/51 - Laboratório de Emergências Clínicas, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 27
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    URINARY BIOMARKER NGAL IN PATIENTS WITH HEPATORENAL SYNDROME: ACCURACY STUDY IN PREDICTION OF NO RESPONSE TO THERAPY WITH ALBUMIN AND TERLIPRESSIN
    (2016) XIMENES, R. O.; HELOU, C.; DINIZ, M.; BARBEIRO, D.; SOUZA, H.; D'ALBUQUERQUE, L. A.; CARRILHO, F.; FARIAS, A.
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    Intestinal Barrier Dysfunction in Ageing Animals With Acute Pancreatitis: Increased Intestinal Inflammation?
    (2015) MACHADO, Marcel C.; SILVA, Fabiano Pinheiro da; CUNHA, Debora G.; BARBEIRO, Denise F.; COELHO, Ana Maria M.; SOUZA, Heraldo P.
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    TLR4 deficiency increases peroxisomal beta-oxidation in LDL knockout mice livers
    (2014) FERREIRA, D. F.; SOUZA, H. P. D.; PRIST, I. H.; FIAMONCINI, J.; ARIGA, S. K.; LIMA, T. M. D.
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    Inflammatory and antioxidant response in obese septic shock patients
    (2013) VICTORINO, Vanessa Jacob; BARBEIRO, Hermes Vieira; BARBEIRO, Denise Frediani; SILVA, Fabiano Pinheiro; SOUZA, Heraldo Possolo
    There is no consensus about the influence of obesity on sepsis. Hence, we evaluated the inflammatory and antioxidant response in obese patients (body mass index > 30) with septic shock compared to non-infected obese and non-obese septic patients. Blood samples were obtained from 27 critically ill patients admitted to ICUs in Clinics Hospital, Universidade de Sao Paulo. Cytokines were measured by ELISA Milliplex and antioxidant activity by colorimetric methods. There are small differences in the cytokine profiles in obese septic patients (n=6), compared to obese non-infected ones (n=10). Only FGF2, TGF-α, IFN-α2, IFN-{gamma}, IL-10, MCP-3, IL-13 and IL-15 presented significantly higher levels in septic patients. Interestingly, there was a marked increase in superoxide dismutase (SOD) and catalase (CAT) activity in erythrocytes from the septic group. Compared to their non-obese septic counterparts, septic obese patients presented significantly lower levels of FGF2, IL-4, TNF-β and VEGF. SOD activity was higher in this group, compared to non-obese patients. We concluded that obese patients with septic shock maintain cytokine levels similar to the ones observed in their non-obese counterparts, while increasing their antioxidant activity.
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    COVID-19 and H1N1 Pneumonia: Reanalysis and Comparison of Two Cohorts
    (2022) SORICE, E.; STERNLICHT, J.; SANTOS, L. B.; BRANDAO, R.; MARINO, L.; MARCHINI, J.; ALENCAR, J.; GOMEZ, L.; SOUZA, H.
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    Effect of low level laser therapy on lung mechanics and inflammatory response
    (2013) CURY, Vivian; LIMA, Thais; ARIGA, Suely; BARBEIRO, Denise; PINHEIRO, Nathalia; PRADO, Carla Maximo; MORETTI, Ana Iochabel; SOUZA, Heraldo Possolo
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    Late remodeling of extracellular matrix after acute inflammatory injury or chronic distension
    (2012) PRIST, Iryna Hirata; SALLES, Alessandra Grassi; SALGADO, Thais M. de Lima; SOUZA, Heraldo Possolo De
    Extracellular matrix remodeling is a crucial step in the healing process after inflammatory or infectious insult. We studied the role of matrix metalloproteinases in models of disease secondary to an acute inflammatory injury (burned skin) or chronic aggression (skin from obese patients submitted to gastroplasty). Skin samples were extracted using a 4 mm punch from abdomen of patients in late post-operative of bariatric surgery, recovered from third degree burns or control subjects. RNA was extracted by TRIzol and evaluated by quantitative PCR. MMPs activity was determined by zymography. In skin from burned patients, MMPs 2 and 9 expression was not different from control subjects. Obese patients present a higher MMP2 expression, compared to controls (2.4±0.56 x 1.0±0.1, respectively, p<0.05), however MMP9 mRNA was not detectable in these patients, even when conventional PCR was used. Interestingly, in spite of higher mRNA amounts, MMP2 activity was reduced in burned patients compared to controls (1.3±0.1 x 2.6±0.5 A.U., respectively, p<0.05), while MMP9 activity had a large variability, preventing any conclusion. We conclude that an acute inflammatory stimulus leads to late decreased MMP2 activity, what can explain the extensive fibrosis observed in these patients. In a more prolonged injury, due to chronic skin distension caused by obesity, MMP9 expression is affected leading to flabby skin deposits.
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    Nitric Oxide Activates p21(ras) by S-Nitrosylation during Loss of Integrin-Mediated Cell-Matrix Contact Leading to Increased Superoxide Level and Cell Survival
    (2012) MELO, Fabiana Henriques; MOLOGNONI, Fernanda; MORETTI, Ana; SOUZA, Heraldo Possolo de; JASIULIONIS, Miriam Galvonas
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    Urinary NGAL biomarker predicts non response to therapy with albumin and terlipressin in patients with hepatorenal syndrome
    (2016) XIMENES, Rafael O.; HELOU, Claudia; BARBEIRO, Denise F.; SOUZA, Heraldo; MIGITA, Beatriz; D'ALBUQUERQUE, Luiz C.; CARRILHO, Flair J.; FARIAS, Alberto O.
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    Brazilian Airway Registry COoperation: The First 1,000 Emergency Intubations of the BARCO Study
    (2023) MAIA, I. W. A.; ALENCAR, J.; MARCHINI, J.; SILVA, E. L. O. J.; GOMES, L.; MARINO, L.; VAISBERG, V.; STANZANI, G.; NOGUEIRA, C.; KROEFF, B.; SOUZA, H.