BRUNO MAHLER MIOTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
3 resultados
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- Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: A clinical trial(2013) CORREA, Telma A. F.; ROGERO, Marcelo M.; MIOTO, Bruno M.; TARASOUTCHI, Daniela; TUDA, Vera L.; CESAR, Luiz A. M.; TORRES, Elizabeth A. F. S.Objective: The aim of this study was to compare the effects of medium light roast (MLR) and medium roast (MR) paper-filtered coffee on cardiovascular risk factors in healthy volunteers. Methods: This randomized crossover trial compared the effects of consuming three or four cups (150 mL) of MLR or MR coffee per day for 4 wk in 20 healthy volunteers. Plasma lipids, lipoprotein(a) (Lp[a]), total homocysteine, and endothelial dysfunction-related inflammation biomarkers, serum glycemic biomarkers, and blood pressure were measured at baseline and after each intervention. Results: Both roasts increased plasma total cholesterol, low-density lipoprotein-cholesterol, and soluble vascular cell adhesion molecule-1 (sVCAM-1) concentrations (10%, 12%, and 18% for MLR; 12%, 14%, and 14% for MR, respectively) (P < 0.05). MR also increased high-density lipoportein-cholesterol concentration by 7% (P = 0.003). Plasma fibrinogen concentration increased 8% after MR intake (P = 0.01), and soluble E-selectin increased 12% after MLR intake (P = 0.02). No changes were observed for Lp(a), total homocysteine, glycemic biomarkers, and blood pressure. Conclusion: Moderate paper-filtered coffee consumption may have an undesirable effect on plasma cholesterol and inflammation biomarkers in healthy individuals regardless of its antioxidant content.
conferenceObject Effect of coffee consumption on blood pressure and exercise tolerance(2012) MIOTO, B. M.; MORETTI, M. A.; TARASOUTCHI, D.; DIAS, K. M.; AMATO, R. V.; MASSAROPPE, L.; VIANNA, C. B.; CESAR, L. A. MachadoPurpose: Coffee is the most abundantly consumed stimulant worldwide. However, its cardiovascular safely remains controversial. Some studies suggest coffee consumption acutely can determine a slight blood pressure raise and improve exercise tolerance. AIM: We evaluated blood pressure and exercise tolerance before and after daily chronic coffee consumption in a group of healthy volunteers and in patients with coronary artery disease. Methods: We did a prospective random crossed-over trial to evaluate two different types of roasted coffee. All individuals were oriented by the same nutritionist and put on 3 weeks washout for caffeine beverages and foods. Then they were randomly assigned to start drinking filtered coffee first in one style-roasted coffee and then crossed-over to the other style. Ground coffee beans, provided for four weeks each, were medium-dark (MD) and dark (D) roasts. After 4 weeks there were cross-over with a total of 8 weeks of drinking coffee. All individuals were taught the amount of coffee to brew each time. They get instructions to drink 450 to 600ml every single day. In the baseline and after each period of drinking they were submitted to treadmill test and ambulatory blood pressure monitoring (24-h ABPM). We did analyze average systolic blood pressure (SBP) and diastolic blood pressure (DBP) from 24-h ABPM, total exercise time(TExercise)and double product (DP) from treadmill test. Variable means were evaluated by the analysis of variance for repeated measures. Results: We evaluated 80 subjects (26 with coronary artery disease and 54 healthy volunteers) with 53.4±13.5 years old, 35 men and 45 women (see table). Conclusions: Both roast raised total exercise time capacity, without an increase in double product. Medium dark roasted coffee consumption, but not dark, promoted a slight blood pressure elevation. These findings suggest that there are substances other than caffeine that raises blood pressure and is degraded by roasting.- Medium Light and Medium Roast Paper-Filtered Coffee Increased Antioxidant Capacity in Healthy Volunteers: Results of a Randomized Trial(2012) CORREA, Telma Angelina Faraldo; MONTEIRO, Marcela Piedade; MENDES, Thaise Maria Nogueira; OLIVEIRA, Daniela Moura de; ROGERO, Marcelo Macedo; BENITES, Cibelem Iribarrem; VINAGRE, Carmen Guilherme Christiano de Matos; MIOTO, Bruno Mahler; TARASOUTCHI, Daniela; TUDA, Vera Lucia; CESAR, Luiz Antonio Machado; TORRES, Elizabeth Aparecida Ferraz da SilvaWe compared the effects of medium light roast (MLR) and medium roast (MR) paper-filtered coffee on antioxidant capacity and lipid peroxidation in healthy volunteers. In a randomized crossover study, 20 volunteers consumed 482 +/- 61 ml/day of MLR or MR for four weeks. Plasma total antioxidant status (TAS), oxygen radical absorbance capacity (ORAC), oxidized LDL and 8-epi-prostaglandin F2 alpha, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activity were measured at baseline and after the interventions. MLR had higher chlorogenic acids-(CGA; 334 mg/150 mL) and less caffeine (231 mg/150 ml) than MR had (210 and 244 mg/150 ml, respectively). MLR also had fewer Maillard reaction products (MRP) than MR had. Compared with baseline, subjects had an increase of 21 and 26 % in TAS, 13 and 13 % in CAT, 52 and 75 % in SOD, and 62 and 49 % in GPx after MLR and MR consumption (P < 0.001), respectively. ORAC increased after MLR (P = 0.004). No significant alteration in lipid peroxidation biomarkers was observed. Both coffees had antioxidant effects. Although MLR contained more CGA, there were similar antioxidant effects between the treatments. MRP may have contributed as an antioxidant. These effects may be important in protecting biological systems and reducing the risk of diseases related to oxidative stress.