ANDRE BROOKING NEGRAO
Projetos de Pesquisa
Unidades Organizacionais
IPER, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
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bookPart Transtornos relacionados ao uso de sedativos/hipnóticos e alucinógenos(2021) NEGRãO, André Brooking- GENOME-WIDE DNA METHYLATION ANALYSIS IN THE SALIVA OF CRACK COCAINE DEPENDENTS(2019) CAMILO, Caroline; MASCHIETTO, Mariana; NEGRAO, Andre Brooking; RIBEIRO, Marcelo; LARANJEIRA, Ronaldo; BRENTANI, Helena; VALLADA, Homero
- Butyrylcholinesterase Genetic Variants: Association with Cocaine Dependence and Related Phenotypes(2013) NEGRAO, Andre Brooking; PEREIRA, Alexandre Costa; GUINDALINI, Camila; SANTOS, Hadassa Campos; MESSAS, Guilherme Peres; LARANJEIRA, Ronaldo; VALLADA, HomeroObjective: The search for genetic vulnerability factors in cocaine dependence has focused on the role that neuroplasticity plays in addiction. However, like many other drugs, the ability of an individual to metabolize cocaine can also influence susceptibility to dependence. Butyrylcholinesterase (BChE) metabolizes cocaine, and genetic variants of the BChE gene (BCHE) alter its catalytic activity. Therefore, we hypothesize that cocaine users with polymorphisms in BCHE can show diverse addictive behaviors due to differences in effective plasma concentrations of cocaine. Those polymorphisms might also influence users to prefer one of the two main preparations (crack or powder cocaine), despite having equal access to both. The present work investigates polymorphisms in BCHE and if those genetic variants constitute risk factors for cocaine dependence and for crack cocaine use. Methods: A total of 1,436 individuals (698 cocaine-dependent patients and 738 controls) were genotyped for three single nucleotide polymorphisms (SNPs) in BCHE: rs1803274, rs4263329, and rs4680662. Results: For rs4263329, a nominal difference was found between cases and controls. For rs1803274 (the functional SNP), a statistically significant difference was found between patients who used crack cocaine exclusively and those who used only powder cocaine (P = 0.027; OR = 4.36; 95% CI = 1.18-16.04). Allele frequencies and genotypes related to other markers did not differ between cases and controls or between the two cocaine subgroups. Conclusions: Our findings suggest that the AA genotype of rs1803274 is a risk factor for crack cocaine use, which is more addictive than powder cocaine use. Further studies are needed in order to confirm this preliminary result and clarify the role of BCHE and its variants in cocaine dependence.
- Pharmacological Treatment of Alcohol Cravings(2023) MARIN, Matheus Cheibub David; PEDRO, Maria Olivia Pozzolo; PERROTTE, Giuliana; MARTINS-DA-SILVA, Anderson S.; LASSI, Dangela L. S.; BLAAS, Israel Kanaan; CASTALDELLI, Fernando Ikeda; SANTOS, Maria Beatriz Brisola dos; KORTAS, Guilherme Trevizan; CAMPOS, Marcela Waisman; TORALES, Julio; VENTRIGLIO, Antonio; PERICO, Cintia de Azevedo-Marques; NEGRAO, Andre B.; LEOPOLDO, Kae; ANDRADE, Arthur Guerra de; MALBERGIER, Andre; CASTALDELLI-MAIA, Joao Mauricio(1) Background: The treatment of substance addiction is challenging and has persisted for decades, with only a few therapeutic options. Although there are some recommendations for specific treatments for Alcohol Use Disorder (AUD), there is no specific medication used to treat alcohol cravings, which could benefit millions of patients that are suffering from alcoholism. Cravings, or the urge to use drugs, refer to the desire to experience the effects of a previously experienced psychoactive substance. (2) Methods: We included original studies of alcohol abuse or dependence extracted from a controlled, blind, pharmacological treatment study which presented measures and outcomes related to alcohol cravings. (3) Results: Specific drugs used for the treatment of alcoholism, such as Naltrexone and Acamprosate, have had the best results in relieving craving symptoms, as well as promoting abstinence. Baclofen and anticonvulsants such as Gabapentin and Topiramate have shown good results in promoting abstinence and the cessation of cravings. (4) Conclusions: Specific drugs used for the treatment of alcoholism to obtain the best results can be considered the gold standard for promoting abstinence and relieving cravings. Anticonvulsants and Baclofen also had good results, with these medications being considered as second-line ones. Varenicline is an option for alcohol dependents who also concomitantly ingest tobacco.
- GENOME-WIDE ASSOCIATION STUDY OF COMORBID DEPRESSION AND ANXIETY SYMPTOMS IN AN EXTENDED PEDIGREE COHORT(2019) NEGRAO, Andre Brooking; TAPOROSKI, Tamara; ESTEBAN, Nubia; SCHANTZ, Malcolm von; VALLADA, Homero; PEREIRA, Alexandre Costa
- IDENTIFICATION OF NOVEL GWAS HITS FOR SEMANTIC VERBAL FLUENCY: RESULTS FROM A FAMILY-BASED STUDY(2019) TAPOROSKI, Tamara; SCHANTZ, Malcolm Von; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; POMPEIA, Sabine; EVANS, Simon; KRIEGER, Jose E.; VALLADA, Homero; NEGRAO, Andre Brooking; PEREIRA, Alexandre C.
- Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study(2015) SCHANTZ, Malcolm von; TAPOROSKI, Tamara P.; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; VALLADA, Homero; KRIEGER, Jose E.; PEDRAZZOLI, Mario; NEGRAO, Andre B.; PEREIRA, Alexandre C.Diurnal preference (chronotype) is a useful instrument for studying circadian biology in humans. It harbours trait-like dimensions relating to circadian period and sleep homeostasis, but also has ontogenetic components (morningness increases with age). We used the Morningness-Eveningness questionnaire (MEQ) in the Baependi study, a family-based cohort study based in a small town in Minas Gerais, Brazil. The population is highly admixed and has a cohesive and conservative lifestyle. 825 individuals (497 female) aged 18-89 years (average +/- SD = 46.4 +/- 16.3) and belonging to 112 different families participated in this study. The average MEQ score was 63.5 +/- 11.2 with a significant (P < 0.0001) linear increase with age. Morningness was significantly (P, 0.0001) higher in the rural (70.2 +/- 9.8) than in the municipal zone (62.6 +/- 11.1), and was also significantly (P = 0.025) higher in male (64.6 +/- 10.9) than in female (62.8 +/- 11.2) participants. Thus, in spite of universal access to electricity, the Baependi population was strongly shifted towards morningness, particularly in the rural zone. Heritability of MEQ score was 0.48 when adjusted for sex and age, or 0.38 when adjusted for sex, age, and residential zone. The reported MEQ score heritability is more akin to those of previous twin studies than previous family studies.
conferenceObject GENETIC EPIDEMIOLOGY OF INSOMNIA IN THE BAEPENDI HEART COHORT STUDY(2019) AHMED, S. S.; TAPOROSKI, T. P.; GOMEZ, L. M.; RUIZ, F. S.; BEIJAMINI, F.; HORIMOTO, A. R. V. R.; NEGRAO, A. B.; KNUTSON, K. L.; PEREIRA, A. C.; STERR, A.; SCHANTZ, M. von- Metabolic syndrome alters relationships between cardiometabolic variables, cognition and white matter hyperintensity load(2019) ALKAN, E.; TAPOROSKI, T. P.; STERR, A.; SCHANTZ, M. von; VALLADA, H.; KRIEGER, J. E.; PEREIRA, A. C.; ALVIM, R.; HORIMOTO, A. R. V. R.; POMPEIA, S.; NEGRAO, A. B.; EVANS, S. L. H.Cardiometabolic risk factors influence white matter hyperintensity (WMH) development: in metabolic syndrome (MetS), higher WMH load is often reported but the relationships between specific cardiometabolic variables, WMH load and cognitive performance are uncertain. We investigated these in a Brazilian sample (aged 50-85) with (N = 61) and without (N=103) MetS. Stepwise regression models identified effects of cardiometabolic and demographic variables on WMH load (from FLAIR MRI) and verbal recall performance. WMH volume was greater in MetS, but verbal recall performance was not impaired. Age showed the strongest relationship with WMH load. Across all participants, systolic blood pressure (SBP) and fasting blood glucose were also contributors, and WMH volume was negatively associated with verbal recall performance. In non-MetS, higher HbA1c, SBP, and number of MetS components were linked to poorer recall performance while higher triglyceride levels appeared to be protective. In MetS only, these relationships were absent but education exerted a strongly protective effect on recall performance. Thus, results support MetS as a construct: the clustering of cardiometabolic variables in MetS alters their individual relationships with cognition; instead, MetS is characterised by a greater reliance on cognitive reserve mechanisms. In non-MetS, strategies to control HbA1c and SBP should be prioritised as these have the largest impact on cognition.
- Bariatric surgery and it influence in alcohol consumption-differences before and after surgery, a systematic review and meta-analysis(2023) VIDES, Mariana Capelo; OLIVEIRA, Mariana Campello de; LASSI, Dangela Layne Silva; MALBERGIER, Andre; FLORIO, Ligia; PERICO, Cintia de Azevedo-Marques; AMARAL, Ricardo Abrantes do; TORALES, Julio; VENTRIGLIO, Antonio; NEGRAO, Andre Brooking; CASTALDELLI-MAIA, Joao MauricioBackgroundThrough new publications on the subject, the main goal of this article is to seek a change in the pattern of alcohol use before and after bariatric surgery.MethodsWe searched the National Library of Medicine, CINAHL, and PsycINFO databases. We included original articles regarding alcohol consumption before and after bariatric surgery to conduct the systematic review.ResultsOur systematic review, which included 18 articles, yielded mixed results. Meta-analysis of six articles did not reveal statistically significant differences in alcohol use behaviours before and one year after bariatric surgery. However, throughout the perspective of follow-up after bariatric surgery, nine out of the twelve articles showed improvement in the pattern of alcohol consumption when evaluated up to two years after the end of the surgical period, and four out of the five articles with monitoring beyond two years showed worsening in consumption, compared to pre-surgery alcohol use behaviours.ConclusionsConclusions about the relationship between alcohol consumption and bariatric surgery are challenging primarily because of the variety of the methods used and the alcohol consumption measures. Despite that, our research pointed to an increased risk of alcohol use disorders two years after bariatric surgery.