EDUARDO GOMES LIMA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
17 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 17
- The ORBITA trial: A point of view(2018) OLIVEIRA, Vitor Dornela de; GIUGNI, Fernando Rabioglio; MARTINS, Eduardo Bello; AZEVEDO, Diogo Freitas Cardoso de; LIMA, Eduardo Gomes; SERRANO JUNIOR, Carlos VicenteTreatment of stable coronary artery disease (CAD) relies on improved prognosis and relief of symptoms. National and international guidelines on CAD support the indication for revascularization in patients with limiting symptoms and refractory to drug treatment. Previous studies attested the efficacy of angioplasty to improve angina as well as the functional capacity of patients with symptomatic stable CAD. The ORBITA trial, recently published in an international journal, showed no benefit in terms of exercise tolerance compared to a placebo procedure in a population of single-vessel patients undergoing contemporary percutaneous coronary intervention. In this point of view article, the authors discuss the ORBITA trial regarding methodological issues, limitations and clinical applicability.
conferenceObject Impact of chronic kidney disease on diabetic patients with stable coronary disease undergoing surgery, angioplasty or medical treatment in a ten-year follow-up(2018) BATISTA, D. V.; HUEB, W.; LINHARES FILHO, J. P. P.; SILVA, R. R.; LIMA, E. G.; REZENDE, P. C.; MARTINS, E. B.; GARZILLO, C. L.; AZEVEDO, D. F. C.; RAMIRES, J. A. F.; KALIL FILHO, R.conferenceObject SYNTAX score and outcomes after coronary artery bypass grafting: a long-term follow-up analysis(2018) MARTINS, E. B.; HUEB, W.; SILVA, R. R.; LINHARES FILHO, J. P. P.; BATISTA, D. V.; RIBAS, F. F.; REZENDE, P. C.; LIMA, E. G.; AZEVEDO, D. F. C.; RAMIRES, J. A. F.; KALIL FILHO, R.- Impact of diabetes mellitus on ischemic cardiomyopathy. Five-year follow-up. REVISION-DM trial(2018) HUEB, Thiago; ROCHA, Mauricio S.; SIQUEIRA, Sergio F.; NISHIOKA, Silvana Angelina D'Orio; PEIXOTO, Giselle L.; SACCAB, Marcos M.; LIMA, Eduardo Gomes; GARCIA, Rosa Maria Rahmi; RAMIRES, Jos Antonio F.; KALIL FILHO, Roberto; MARTINELLI FILHO, MartinoBackground: Patients with ischemic cardiomyopathy and severe left ventricular dysfunction have a worse survival prognosis than patients with preserved ventricular function. The role of diabetes in the long-term prognosis of this patient group is unknown. This study investigated whether the presence of diabetes has a long-term impact on left ventricular function. Methods: Patients with coronary artery disease who underwent coronary artery bypass graft surgery, percutaneous coronary intervention, or medical therapy alone were included. All patients had multivessel disease and left ventricular ejection fraction measurements. Overall mortality, nonfatal myocardial infarction, stroke, and additional interventions were investigated. Results: From January 2009 to January 2010, 918 consecutive patients were selected and followed until May 2015. They were separated into 4 groups: G1, 266 patients with diabetes and ventricular dysfunction; G2, 213 patients with diabetes without ventricular dysfunction; G3, 213 patients without diabetes and ventricular dysfunction; and G4, 226 patients without diabetes but with ventricular dysfunction. Groups 1, 2, 3, and 4, respectively, had a mortality rate of 21.6, 6.1, 4.2, and 10.6% (P < .001); nonfatal myocardial infarction of 5.3, .5, 7.0, and 2.6% (P < .001); stroke of .40, .45, .90, and .90% (P = NS); and additional intervention of 3.8, 11.7, 10.3, and 2.6% (P < .001). Conclusion: In this sample, regardless of the treatment previously received patients with or without diabetes and preserved ventricular function experienced similar outcomes. However, patients with ventricular dysfunction had a worse prognosis compared with those with normal ventricular function; patients with diabetes had greater mortality than patients without diabetes.
conferenceObject Abnormal Release of Cardiac Biomarkers in the Presence of Myocardial Edema Evaluated by Cardiac Magnetic Resonance After Uncomplicated Revascularization Procedures(2018) RIBAS, Fernando F.; REZENDE, Paulo C.; BOROS, Gustavo A.; DALLAZEN, Anderson R.; LINHARES FILHO, Jaime P.; NOMURA, Cesar H.; ROCHITTE, Carlos E.; VILLA, Alexandre V.; LIMA, Eduardo G.; CARVALHO, Guilherme F.; HUEB, Whady; RAMIRES, Jose A.; KALIL FILHO, RobertoconferenceObject Cost-effectiveness analysis of on-pump and off-pump coronary artery bypass grafting for patients with multivesselcoronary artery disease: a Markov model based on data from the MASS III trial(2018) SCUDELER, T. L.; HUEB, W.; SOAREZ, P. C. De; CAMPOLINA, A. G.; HUEB, A. C.; REZENDE, P. C.; LIMA, E. G.; GARZILLO, C. L.; RIBAS, F. F.; TAKIUTI, M. E.; RAMIRES, J. A. F.; KALIL FILHO, R.conferenceObject Impact of glycated hemoglobin in diabetic patients with coronary artery disease undergoing surgery, angioplasty or clinical treatment in a very long-term follow-up(2018) LINHARES FILHO, J. P. P.; HUEB, W.; BATISTA, D. V.; SILVA, R. R.; LIMA, E. G.; REZENDE, P. C.; MARTINS, E. B.; GARZILLO, C. L.; AZEVEDO, D. F. C.; RAMIRES, J. A. F.; KALIL FILHO, R.- Cost-effectiveness of on-pump and off-pump coronary artery bypass grafting for patients with coronary artery disease: Results from the MASS III trial(2018) SCUDELER, Thiago Luis; HUEB, Whady A.; FARKOUH, Michael E.; MARON, David J.; SOAREZ, Patricia Coelho de; CAMPOLINA, Alessandro Goncalves; TAKIUTI, Myrthes Emy; REZENDE, Paulo Cury; GODOY, Lucas Colombo; HUEB, Alexandre Ciapinina; LIMA, Eduardo Gomes; GARZILLO, Cibele Larroza; RAMIRES, Jose Antonio Franchini; KALIL FILHO, RobertoBackground: Recent trials have reported similar clinical outcomes between on-pump and off-pump coronary artery bypass graft (CABG). However, long-term cost-effectiveness of these strategies is unknown. Methods: A prespedfied economic study was performed based on the MASS Ill trial. Costs were estimated for all patients based on observed healthcare resource usage over a 5-year follow-up. Health state utilities were evaluated with the SF-6D questionnaire. Cost-effectiveness was assessed as cost per quality-adjusted life-year (QALY) gained using a Markov model. Probabilistic sensitivity analysis with the Monte-Carlo simulation and cost-effectiveness acceptability curve were used to address uncertainty. Results: Quality of life improved significantly in both groups during follow-up compared with baseline. At 5 years, when comparing on-pump and off-pump CABG groups, no differences were found in cumulative life-years (4.851 and 4.766 years, P = .319) and QALY gained (4.150 and 4.105 QALYs, P = .332). Mean cost in US dollars per patient during the trial did not differ significantly between the on-pump and off-pump groups ($5890.29 and $5674.75, respectively, P = .409). Over a lifetime horizon, the incremental cost-effectiveness ratio of on-pump versus off-pump CABG was $12,576 per QALY gained, which is above the suggested cost-effectiveness threshold range (from $3210 to 10,122). In the sensitivity analysis, the probability that on-pump CABG is cost-effective compared to off-pump surgery for a willingness-to-pay threshold of $3212 per QALY gained was <1%. For the $10,122 per QALY threshold, the same probability was 35%. Conclusion: This decision-analytic model suggests that on-pump CABG is not cost-effective when compared to off-pump CABG from a public health system perspective.
conferenceObject Cardiac Biomarkers Elevation After Myocardial Revascularization Predicts Cardiovascular Prognosis. Long-Term Follow-Up of Mass-V Study(2018) LINHARES FILHO, Jaime P.; HUEB, Whady; V, Daniel Batista; LIMA, Eduardo G.; SILVA, Rafael R.; REZENDE, Paulo C.; STRUNZ, Celia M.; MARTINS, Eduardo B.; GARZILLO, Cibele L.; AZEVEDO, Diogo F.; DALLAZEN, Anderson R.; RIBAS, Fernando F.; RAMIRES, Jose A.; KALIL FILHO, RobertoconferenceObject Long-Term Analysis of Ventricular Function in Patients With Stable Coronary Disease Underwent On-Pump or Off-Pump Coronary Artery Bypass Graft in Mass III(2018) SILVA, Rafael R.; HUEB, Whady; LIMA, Eduardo G.; MARTINS, Eduardo B.; V, Daniel Batista; LINHARES FILHO, Jaime P.; REZENDE, Paulo C.; GARZILLO, Cibele L.; RAMIRES, Jose A.; KALIL FILHO, Roberto