FABIO LUIS DE SOUZA DURAN
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
10 resultados
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- Country-level gender inequality is associated with structural differences in the brains of women and men(2023) ZUGMAN, Andre; ALLIENDE, Luz Maria; MEDEL, Vicente; BETHLEHEM, Richard A. I.; SEIDLITZ, Jakob; RINGLEIN, Grace; ARANGO, Celso; ARNATKEVICIUTE, Aurina; ASMAL, Laila; BELLGROVE, Mark; BENEGAL, Vivek; BERNARDO, Miquel; BILLEKE, Pablo; BOSCH-BAYARD, Jorge; BRESSAN, Rodrigo; BUSATTO, Geraldo F.; CASTRO, Mariana N.; CHAIM-AVANCINI, Tiffany; COMPTE, Albert; COSTANZI, Monise; CZEPIELEWSKI, Leticia; DAZZAN, Paola; FUENTE-SANDOVAL, Camilo de la; FORTI, Marta Di; DIAZ-CANEJA, Covadonga M.; DIAZ-ZULUAGA, Ana Maria; PLESSIS, Stefan Du; DURAN, Fabio L. S.; FITTIPALDI, Sol; FORNITO, Alex; FREIMER, Nelson B.; GADELHA, Ary; GAMA, Clarissa S.; GARANI, Ranjini; GARCIA-RIZO, Clemente; CAMPO, Cecilia Gonzalez; GONZALEZ-VALDERRAMA, Alfonso; GUINJOAN, Salvador; HOLLA, Bharath; IBANEZ, Agustin; IVANOVIC, Daniza; JACKOWSKI, Andrea; LEON-ORTIZ, Pablo; LOCHNER, Christine; LOPEZ-JARAMILLO, Carlos; LUCKHOFF, Hilmar; MASSUDA, Raffael; MCGUIRE, Philip; MIYATAAAA, Jun; MIZRAHI, Romina; MURRAY, Robin; OZERDEM, Aysegul; PAN, Pedro M.; PARELLADA, Mara; PHAHLADIRA, Lebogan; RAMIREZ-MAHALU, Juan P.; RECKZIEGEL, Ramiro; MARQUES, Tiago Reis; REYES-MADRIGAL, Francisco; ROOS, Annerine; ROSA, Pedro; SALUM, Giovanni; SCHEFFLER, Freda; SCHUMANN, Gunter; SERPA, Mauricio; STEIN, Dan J.; TEPPER, Angeles; TIEGO, Jeggan; UENO, Tsukasa; UNDURRAGA, Juan; UNDURRAG, Eduardo A.; VALDES-SOSAOOO, Pedro; VALLIY, Isabel; VILLARREALU, Mirta; WINTON-BROWNRRR, Toby T.; YALIN, Nefize; ZAMORANO, Francisco; ZANETTI, Marcus V.; WINKLER, Anderson M.; PINE, Daniel S.; EVANS-LACKO, Sara; CROSSLEY, Nicolas A.Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We also know that the brain is shaped by nurturing and adverse socio-environmental experiences. Therefore, unequal exposure to harsher conditions for women compared to men in gender-unequal countries might be reflected in differences in their brain structure, and this could be the neural mechanism partly explaining women's worse outcomes in gender-unequal countries. We examined this through a random-effects meta-analysis on cortical thickness and surface area differences between adult healthy men and women, including a meta-regression in which country-level gender inequality acted as an explanatory variable for the observed differences. A total of 139 samples from 29 different countries, totaling 7,876 MRI scans, were included. Thickness of the right hemisphere, and particularly the right caudal anterior cingulate, right medial orbitofrontal, and left lateral occipital cortex, presented no differences or even thicker regional cortices in women compared to men in gender-equal countries, reversing to thinner cortices in countries with greater gender inequality. These results point to the potentially hazardous effect of gender inequality on women's brains and provide initial evidence for neuroscience-informed policies for gender equality.
- A voxel-based morphometry study of gray matter correlates of facial emotion recognition in bipolar disorder(2015) NEVES, Maila de Castro L.; ALBUQUERQUE, Maicon Rodrigues; MALLOY-DINIZ, Leandro; NICOLATO, Rodrigo; NEVES, Fernando Silva; SOUZA-DURAN, Fabio Luis de; BUSATTO, Geraldo; CORREA, HumbertoFacial emotion recognition (FER) is one of the many cognitive deficits reported in bipolar disorder (BD) patients. The aim of this study was to investigate neuroanatomical correlates of FER impairments in BD type I (BD-l). Participants comprised 21 euthymic BD-1 patients without Axis l DSM IV-TR comorbidities and 21 healthy controls who were assessed using magnetic resonance imaging and the Penn Emotion Recognition Test (ER40). Preprocessing of images used DARTEL (diffeomorphic anatomical registration through exponentiatecl Lie algebra) for optimized voxel-basecl morphometry in SPM8. Compared with healthy subjects, BD-1 patients performed poorly in on the ER40 and had reduced gray matter volume (GMV) in the left orbitofrontal cortex, superior portion of the temporal pole and insula. In the BD-1 group, the statistical maps indicated a direct correlation between 1-ER on the ER40 and right middle cingulate gyrus GMV. Our findings are consistent with the previous studies regarding the overlap of multiple brain networks of social cognition and BD neurobiology, particularly components of the anterior-limbic neural network.
- Structural brain abnormalities in patients with type I bipolar disorder and suicidal behavior(2017) DUARTE, Dante G. G.; NEVES, Maila de Castro L.; ALBUQUERQUE, Maicon R.; TURECKI, Gustavo; DING, Yang; SOUZA-DURAN, Fabio Luis de; BUSATTO, Gerald; CORREA, HumbertoSome studies have identified brain morphological changes in the frontolimbic network (FLN) in bipolar subjects who attempt suicide (SA). The present study investigated neuroanatomical abnormalities in the FLN to find a possible neural signature for suicidal behavior in patients with bipolar disorder type I (BD-I). We used voxel-based morphometry to compare euthymic patients with BD-I who had attempted suicide (n = 20), who had not attempted suicide (n = 19) and healthy controls (HCs) (n = 20). We also assessed the highest medical lethality of their previous SA. Compared to the participants who had not attempted suicide, the patients with BD-I who had attempted suicide exhibited significantly increased gray matter volume (GMV) in the right rostral anterior cingulate cortex (ACC), which was more pronounced and extended further to the left ACC in the high-lethality subgroup (p < 0.05, with family-wise error (FWE) correction for multiple comparisons using small-volume correction). GMV in the insula and orbitofrontal cortex was also related to suicide lethality (p < 0.05, FWE-corrected). The current findings suggest that morphological changes in the FLN could be a signature of previous etiopathogenic processes affecting regions related to suicidality and its severity in BD-I patients.
- Voxel-based morphometric imaging in first-episode psychosis: interrogating the role of familial liability(2023) CORSI-ZUELLI, F. C.; DURAN, F. L. Souza; LOUREIRO, C. M.; SANTOS, A. C. dos; BUSATTO, G.; MENEZES, P. R.; DEL-BEN, C. M.
- Voxelwise evaluation of white matter volumes in first-episode psychosis(2012) COLOMBO, Renata Rodrigues da Cunha; SCHAUFELBERGER, Maristela Spanghero; SANTOS, Luciana Cristina; DURAN, Fabio Luis de Souza; MENEZES, Paulo Rossi; SCAZUFCA, Marcia; BUSATTO, Geraldo Filho; ZANETTI, Marcus ViniciusThe occurrence of white matter (WM) abnormalities in psychotic disorders has been suggested by several studies investigating brain pathology and diffusion tensor measures, but evidence assessing regional WM morphometry is still scarce and conflicting. In the present study, 122 individuals with first-episode psychosis (FEP) (62 fulfilling criteria for schizophrenia/schizophreniform disorder, 26 psychotic bipolar I disorder, and 20 psychotic major depressive disorder) underwent magnetic resonance imaging, as well as 94 epidemiologically recruited controls. Images were processed with the Statistical Parametric Mapping (SPM2) package, and voxel-based morphometry was used to compare groups (t-test) and subgroups (ANOVA). Initially, no regional WM abnormalities were observed when both groups (overall FEP group versus controls) and subgroups (i.e., schizophrenia/schizophreniform, psychotic bipolar I disorder, psychotic depression, and controls) were compared. However, when the voxelwise analyses were repeated excluding subjects with comorbid substance abuse or dependence, the resulting statistical maps revealed a focal volumetric reduction in right frontal WM, corresponding to the right middle frontal gyral WM/third subcomponent of the superior longitudinal fasciculus, in subjects with schizophrenia/schizophreniform disorder (n = 40) relative to controls (n = 89). Our results suggest that schizophrenia/schizophreniform disorder is associated with right frontal WM volume decrease at an early course of the illness.
- The Association Between Acquired Color Deficiency and PET Imaging of Neurodegeneration in Mild Cognitive Impairment and Alzheimer Disease(2022) VIDAL, Kallene Summer Moreira; DECLEVA, Diego; BARBONI, Mirella Telles Salgueiro; NAGY, Balazs Vince; MENEZES, Paulo Augusto Hidalgo de; AHER, Avinash; COUTINHO, Artur Martins; SQUARZONI, Paula; FARIA, Daniele de Paula; DURAN, Fabio Luis de Souza; BUCHPIGUEL, Carlos Alberto; KREMERS, Jan; FILHO, Geraldo Busatto; VENTURA, Dora FixPURPOSE. To evaluate color vision changes and retinal processing of chromatic and lumi-nance pathways in subjects with Alzheimer disease (AD) and mild cognitive impairment (MCI) compared with a matched control group and whether such changes are associated with impaired brain glucose metabolism and beta-amyloid deposition in the brain.METHODS. We evaluated 13 patients with AD (72.4 +/- 7.7 years), 23 patients with MCI (72.5 +/- 5.5 years), and 18 controls of comparable age (P = 0.44) using Cambridge color test and the heterochromatic flicker ERG (HF-ERG). The Cambridge color test was performed using the trivector protocol to estimate the protan, deutan and tritan color confusion axes. HF-ERG responses were measured at a frequency of 12 Hz, which ERGs reflect chromatic activity, and at 36 Hz, reflecting luminance pathway. A study subsample was performed using neuropsychological assessments and positron emission tomography.RESULTS. Patients with AD presented higher mean values indicating poorer color discrim-ination for protan (P = 0.04) and deutan (P = 0.001) axes compared with the controls. Along the tritan axis, both patients with AD and patients with MCI showed decreased color vision (P = 0.001 and P = 0.001) compared with controls. The analyses from the HF-ERG protocol revealed no differences between the groups (P = 0.31 and P = 0.41). Diffuse color vision loss was found in individuals with signs of neurodegeneration (protan P = 0.002, deutan P = 0.003 and tritan P = 0.01), but not in individuals with signs of beta-amyloid deposition only (protan P = 0.39, deutan P = 0.48, tritan P = 0.63), regardless of their clinical classification.CONCLUSIONS. Here, patients with AD and patients with MCI present acquired color vision deficiency that may be linked with impaired brain metabolism.
- Gray matter volumes in patients with bipolar disorder and their first-degree relatives(2015) NERY, Fabiano G.; GIGANTE, Alexandre Duarte; AMARAL, Jose A.; FERNANDES, Francy B. F.; BERUTTI, Mariangeles; ALMEIDA, Karla M.; CARNEIROC, Camila de Godoi; DURAN, Fabio Luis Souza; OTADUY, Maria G.; LEITE, Claudia Costa; BUSATTO, Geraldo; LAFER, BenyBipolar disorder (BD) is highly heritable. First-degree relatives of BD patient have an increased risk to develop the disease. We investigated abnormalities in gray matter (GM) volumes in healthy first-degree relatives of BD patients to identify possible brain structural endophenotypes for the disorder. 3D T1-weighted magnetic resonance images were obtained from 25 DSM-IV BD type I patients, 23 unaffected relatives, and 27 healthy controls (HC). A voxel-based morphometry protocol was used to compare differences in GM volumes between groups. BD patients presented reduced GM volumes bilaterally in the thalamus compared with HC. Relatives presented no global or regional GM differences compared with HC. Our negative results do not support the role of GM volume abnormalities as endophenotypes for BD. Thalamic volume abnormalities may be associated the pathophysiology of the disease.
- Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings(2023) PAULA, Jonas Jardim de; PAIVA, Rachel E. R. P.; SOUZA-SILVA, Nathalia Gualberto; ROSA, Daniela Valadao; DURAN, Fabio Luis de Souza; COIMBRA, Roney Santos; COSTA, Danielle de Souza; DUTENHEFNER, Pedro Robles; OLIVEIRA, Henrique Soares Dutra; CAMARGOS, Sarah Teixeira; VASCONCELOS, Herika Martins Mendes; CARVALHO, Nara de Oliveira; SILVA, Juliana Batista da; SILVEIRA, Marina Bicalho; MALAMUT, Carlos; OLIVEIRA, Derick Matheus; MOLINARI, Luiz Carlos; OLIVEIRA, Danilo Bretas de; JANUARIO, Jose Nelio; SILVA, Luciana Costa; MARCO, Luiz Armando De; QUEIROZ, Dulciene Maria de Magalhaes; MEIRA, Wagner; BUSATTO, Geraldo; MIRANDA, Debora Marques; ROMANO-SILVA, Marco AurelioPeople recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflammatory processes. Persistent cognitive impairment compromises daily activities and psychosocial adaptation. Some level of neurological and psychiatric consequences were expected and described in severe cases of COVID-19. However, it is debatable whether neuropsychiatric complications are related to COVID-19 or to unfoldings from a severe infection. Nevertheless, the majority of cases recorded worldwide were mild to moderate self-limited illness in non-hospitalized people. Thus, it is important to understand what are the implications of mild COVID-19, which is the largest and understudied pool of COVID-19 cases. We aimed to investigate adults at least four months after recovering from mild COVID-19, which were assessed by neuropsychological, ocular and neurological tests, immune markers assay, and by structural MRI and (18)FDG-PET neuroimaging to shed light on putative brain changes and clinical correlations. In approximately one-quarter of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging, and correlated with upregulation of peripheral immune markers. Our findings provide evidence of neuroinflammatory burden causing cognitive deficit, in an already large and growing fraction of the world population. While living with a multitude of mild COVID-19 cases, action is required for a more comprehensive assessment and follow-up of the cognitive impairment, allowing to better understand symptom persistence and the necessity of rehabilitation of the affected individuals.
- Mapping brain volumetric abnormalities in never-treated pathological gamblers(2015) FUENTES, Daniel; RZEZAK, Patricia; PEREIRA, Fabricio R.; MALLOY-DINIZ, Leandro F.; SANTOS, Luciana C.; DURAN, Fabio L. S.; BARREIROS, Maria A.; CASTRO, Claudio C.; BUSATTO, Geraldo F.; TAVARES, Hermano; GORENSTEIN, ClariceSeveral magnetic resonance imaging (MRI) studies to date have investigated brain abnormalities in association with the diagnosis of pathological gambling (PG), but very few of these have specifically searched for brain volume differences between PG patients and healthy volunteers (HV). To investigate brain volume differences between PG patients and HV, 30 male never treated PG patients (DSM-IV-TR criteria) and 30 closely matched HV without history of psychiatric disorders in the past 2 years underwent structural magnetic resonance imaging with a 1.5-T instrument. Using Freesurfer software, we performed an exploratory whole brain voxelwise volume comparison between the PG group and the HV group, with false discovery rate correction for multiple comparisons (p <0.05), Using a more flexible statistical threshold (p < 0.01, uncorrected for multiple comparisons), we also measured absolute and regional volumes of several brain structures separately. The voxelwise analysis showed no clusters of significant regional differences between the PG and HV groups. The additional analyses of absolute and regional brain volumes showed increased absolute global gray matter volumes in PG patients relative to the HV group, as well as relatively decreased volumes specifically in the left putamen, right thalamus and right hippocampus (corrected for total gray matter). Our findings indicate that structural brain abnormalities may contribute to the functional changes associated with the symptoms of PG, and they highlight the relevance of the brain reward system to the pathophysiology of this disorder.
- Reply to ""Predominance of visuoconstructive impairment after mild COVID-19?"" by Diez-Cirarda et al. 2022(2023) PAULA, Jonas J. de; DURAN, Fabio L. S.; BUSATTO, Geraldo; MIRANDA, Debora M.; ROMANO-SILVA, Marco A.