FABIO LUIS DE SOUZA DURAN
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
7 resultados
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- Cortical surface abnormalities are different depending on the stage of schizophrenia: A cross-sectional vertexwise mega-analysis of thickness, area and gyrification(2021) ROSA, Pedro Gomes Penteado; ZUGMAN, Andre; CERQUEIRA, Carlos Toledo; SERPA, Mauricio Henriques; DURAN, Fabio Luis de Souza; ZANETTI, Marcus Vinicius; BASSITT, Debora Pastore; ELKIS, Helio; CRIPPA, Jose Alexandre S.; SALLET, Paulo Clemente; GATTAZ, Wagner Farid; HALLAK, Jaime Eduardo Cecilio; LOUZA, Mario Rodrigues; GADELHA, Ary; JACKOWSKI, Andrea Parolin; BRESSAN, Rodrigo Affonseca; BUSATTO FILHO, GeraldoBackground: Brain magnetic resonance imaging studies have not investigated the cortical surface comprehensively in schizophrenia subjects by assessing thickness, surface area and gyrification separately during the first episode of psychosis (FEP) or chronic schizophrenia (ChSch). Methods: We investigated cortical surface abnormalities in 137 FEP patients and 240 ChSch subjects compared to 297 Healthy Controls (HC) contributed by five cohorts. Maps showing results of vertexwise between-group comparisons of cortical thickness, area, and gyrification were produced using T1-weighted datasets processed using FreeSurfer 5.3, followed by validated quality control protocols. Results: FEP subjects showed large clusters of increased area and gyrification relative to HC in prefrontal and insuli cortices (Cohen's d: 0.049 to 0.28). These between-group differences occurred partially beyond the effect of sample. ChSch subjects displayed reduced cortical thickness relative to HC in smaller fronto-temporal foci (d:-0.73 to-0.35), but not beyond the effect of sample. Differences between FEP and HC subjects were associated with male gender, younger age, and earlier illness onset, while differences between ChSch and HC were associated with treatment-resistance and first-generation antipsychotic (FGA) intake independently of sample effect. Conclusions: Separate assessments of FEP and ChSch revealed abnormalities that differed in regional distribution, phenotypes affected and effect size. In FEP, associations of greater cortical area and gyrification abnormalities with earlier age of onset suggest an origin on anomalous neurodevelopment, while thickness reductions in ChSch are at least partially explained by treatment-resistance and FGA intake. Associations of between-group differences with clinical variables retained statistical significance beyond the effect of sample.
- Cannabis use, cognition and brain structure in first-episode psychosis (vol 147, pg 209, 2013)(2013) CUNHA, Paulo Jannuzzi; ROSA, Pedro Gomes P.; AYRES, Adriana de Mello; DURAN, Fabio L. S.; SANTOS, Luciana C.; SCAZUFCA, Marcia; MENEZES, Paulo R.; SANTOS, Bernardo dos; MURRAY, Robin M.; CRIPPA, Jose Alexandre S.; BUSATTO, Geraldo F.; SCHAUFELBERGER, Maristela S.
conferenceObject CONTINUING GREYMATTER CHANGES IN FIRST-EPISODE SCHIZOPHRENIA AND AFFECTIVE PSYCHOSIS(2014) SCHAUFELBERGER, Maristela S.; ROSA, Pedro; ZANETTI, Marcus; DURAN, Fabio; SANTOS, Luciana; MENEZES, Paulo; SCAZFUCA, Marcia; MURRAY, Robin M.; BUSATTO, Geraldo- Cannabis use, cognition and brain structure in first-episode psychosis(2013) CUNHA, Paulo Jannuzzi; ROSA, Pedro Gomes P.; AYRES, Adriana de Mello; DURAN, Fabio L. S.; SANTOS, Luciana C.; SCAZUFCA, Marcia; MENEZES, Paulo R.; SANTOS, Bernardo dos; MURRAY, Robin M.; CRIPPA, Jose Alexandre S.; BUSATTO, Geraldo F.; SCHAUFELBERGER, Maristela S.Cannabis use is highly prevalent worldwide and it is associated with psychosis, but its effects on brain structure and cognition are still controversial. The aim of this paper is to investigate cognitive functioning and brain structure in patients with their first episode of psychosis who used Cannabis. We examined gray matter and lateral ventricle volumes in 28 patients with first-episode psychosis and a history of Cannabis use, 78 patients without a history of Cannabis use and 80 healthy controls who had not used Cannabis. Cognition was assessed using forward and backwards digit span tests, from the Wechsler Memory Scale-Third Edition (WMS-III) and the Controlled Oral Word Association Test (COWAT). Patients with a history of Cannabis use had less brain abnormalities, characterized by gray matter and lateral ventricle volume preservation, as well as less attentional and executive impairments compared to patients without a history of Cannabis use. Cannabis-using patients who develop psychosis have less neurodevelopmental impairment and better cognitive reserve than other psychotic patients; perhaps reflecting different etiological processes.
- CANNABIS EFFECTS ON BRAIN STRUCTURE IN FIRST-EPISODE PSYCHOSIS(2012) CUNHA, Paulo J.; CRIPPA, Jose A.; DURAN, Fabio L.; SCAZUFCA, Marcia; MENEZES, Paulo R.; MURRAY, Robin M.; BUSATTO, Geraldo F.; SCHAUFELBEGER, Maristela S.
- Corpus callosum volumes in recent-onset schizophrenia are correlated to positive symptom severity after 1 year of follow-up(2012) SERPA, Mauricio H.; SCHAUFELBERGER, Maristela S.; ROSA, Pedro G.; DURAN, Fabio L. S.; SANTOS, Luciana C.; MURAY, Robin M.; SCAZUFCA, Marcia; MENEZES, Paulo R.; BUSATTO, Geraldo F.
- STRUCTURAL BRAIN CHANGES IN FIRST-EPISODE SCHIZOPHRENIA: A 4-5 YEAR FOLLOW-UP STUDY USING MRI(2012) SCHAUFELBERGER, Maristela S.; ROSA, Pedro G.; ZANETTI, Marcus V.; DURAN, Fabio L.; MENEZES, Paulo R.; SCAZUFCA, Marcia; MURRAY, Robin M.; BUSATTO, Geraldo F.