ROSA MARIA RODRIGUES PEREIRA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
60 resultados
Resultados de Busca
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- Electroconvulsive Therapy in the Treatment of Catatonia Due To Systemic Lupus Erythematosus(2022) GONCALVES JUNIOR, Jucier; BICALHO, Maria Eugenia Teixeira; GUEDES, Lissiane Karine Noronha; GALLUCCI-NETO, Jose; PEREIRA, Rosa M. R.The use of electroconvulsive therapy in case of catatonia due to systemic lupus erythematosus refractory in treatment with immunosuppressant is rare. Therefore, we report a case of catatonia due to systemic lupus erythematosus treated with electroconvulsive therapy as an adjuvant to cyclophosphamide treatment. A 34-year-old female patient diagnosed with systemic lupus erythematosus attended the rheumatology outpatient clinic with a history of catatonia for 8 weeks and laboratory tests revealed high titers of anti-ds DNA positive anti-RNP and polyclonal gammopathy. cyclophosphamide pulse therapy was scheduled in association with electroconvulsive therapy, in 12 sessions, twice a week. The patient evolved with significant clinical improvement after 6 sessions of electroconvulsive therapy and 2 pulses of cyclophosphamide, with negative anti-ds DNA and normalization of gamma globulin levels. Thus, electroconvulsive therapy should be considered as adjuvant therapy in severe cases of neuropsychiatric systemic lupus erythematosus, including catatonia, especially in those with relapses and poor response to immunosuppressant and psychotropic drugs.
- Development and implementation of the AIDA International Registry for patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis syndrome(2022) CASA, Francesca Della; VITALE, Antonio; CATTALINI, Marco; TORRE, Francesco La; CAPOZIO, Giovanna; GIUDICE, Emanuela Del; MAGGIO, Maria Cristina; CONTI, Giovanni; ALESSIO, Maria; OGUNJIMI, Benson; RAGAB, Gaafar; EMMI, Giacomo; ARAGONA, Emma; GIANI, Teresa; LOPALCO, Giuseppe; PARRONCHI, Paola; SHAHRAM, Farhad; VERRECCHIA, Elena; RICCI, Francesca; CARDINALE, Fabio; NOI, Silvia Di; NUZZOLESE, Rossana; LUBRANO, Riccardo; PATRONITI, Serena; NADDEI, Roberta; SABATO, Vito; HUSSEIN, Mohamed A.; DOTTA, Laura; MASTRORILLI, Violetta; GENTILESCHI, Stefano; TUFAN, Abdurrahman; CAGGIANO, Valeria; HEGAZY, Mohamed Tharwat; SOTA, Jurgen; ALMAGHLOUTH, Ibrahim A.; IBRAHIM, Amr; WIESIK-SZEWCZYK, Ewa; OZKIZILTAS, Burcugul; GROSSO, Salvatore; FRASSI, Micol; TARSIA, Maria; PEREIRA, Rosa Maria R.; TAYMOUR, Maged; GAGGIANO, Carla; COLELLA, Sergio; FABIANI, Claudia; MORRONE, Maria; RUSCITTI, Piero; FREDIANI, Bruno; SPEDICATO, Veronica; GIARDINI, Henrique A. Mayrink; BALISTRERI, Alberto; RIGANTE, Donato; CANTARINI, LucaObjective: Aim of this paper is to illustrate the methodology, design, and development of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to patients with the Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome. Methods: This is a physician-driven, non-population- and electronic-based registry proposed to gather real-world demographics, clinical, laboratory, instrumental and socioeconomic data from PFAPA patients. Data recruitment is realized through the on-line Research Electronic Data Capture (REDCap) tool. This registry is thought to collect standardized information for clinical research leading to solid real-life evidence. The international scope and the flexibility of the registry will facilitate the realization of cutting-edge study projects through the constant updating of variables and the possible merging and transfer of data between current and future PFAPA registries. Results: A total of 112 centers have already been involved from 23 countries and 4 continents starting from August 24th, 2021, to April 6th, 2022. In total 56/112 have already obtained the formal approval from their local Ethics Committees. The platform counts 321 users (113 principal investigators, 203 site investigators, two lead investigators, and three data managers). The registry collects retrospective and prospective data using 3,856 fields organized into 25 instruments, including PFAPA patient's demographics, medical histories, symptoms, triggers/risk factors, therapies, and impact on the healthcare systems. Conclusions: The development of the AIDA International Registry for PFAPA patients will enable the on-line collection of standardized data prompting real-life studies through the connection of worldwide groups of physicians and researchers. This project can be found on NCT 05200715.
- Social impact of disease parameters and damage accrual in adult Brazilian patients with childhood-onset Systemic Lupus Erythematosus(2022) TANIGAVA, Nicolas Y.; SAKAMOTO, Ana P.; FRANCO, Andre S.; BALBI, Gabriela G. M.; SALES, Lucas P.; AIKAWA, Nadia E.; TERRERI, Maria T.; PEREIRA, Rosa M. R.Objectives To describe the frequency and investigate potential associations of unemployment, need of financial assistance and health-related quality of life in adult patients with childhood-onset Systemic Lupus Erythematosus (cSLE). Methods In this multicenter cross-sectional retrospective cohort study including cSLE adult patients, questionnaires were applied evaluating demographic characteristics, medical history, treatment, receipt of government financial assistance, work status, quality of life, economic classification, disease activity, and damage accrual. Disease activity and disease damage were measured at the study visit. Results Sixty-nine cSLE patients with a median age of 21 years from two Brazilian tertiary centers were included (median disease duration 9 years). Twenty-eight (40.6%) patients were unemployed and 16 (23.2%) were receiving financial assistance or retirement pension. Work unemployment was associated with higher damage scores (OR 1.83, 95% CI 1.08 to 3.09, p = 0.024), and the need of financial assistance was associated with longer disease duration (OR 1.15, 95% CI 1.00 to 1.31, p = 0.045) and worse economic score (OR 0.87, 95% CI 0.77 to 0.99, p = 0.038). Emotional health and body image perception were the most compromised domains of quality of life but showed no association with disease parameters. Disease activity, on the other hand, was inversely associated with symptoms scores (beta = -1.377, p = 0.014) and scores of adverse effects of medications (beta = -1.286, p = 0.020). Conclusion cSLE is a disease with severe outcomes and high social burden that profoundly impacts patients. Damage accrual is a major contributor to unemployment during adulthood and its prevention must be central in the management of cSLE.
- High prevalence of fatigue in patients with Takayasu arteritis: a case-control study in a Brazilian centre(2022) SANTOS, Alexandre Moura dos; MISSE, Rafael Giovani; BORGES, Isabela Bruna Pires; SILVA, Sarah Luiza Gomes da; KIM, Ana Woo Sook; PEREIRA, Rosa Maria R.; SHINJO, Samuel KatsuyukiObjectives. Several studies have shown not only a high prevalence of fatigue but also a reduction in health-related quality of life (HRQoL) in patients with rheumatic diseases. Owing to insufficient research in this area, we aimed to assess the prevalence of fatigue and its contribution to impairment of HRQoL in patients with Takayasu arteritis (TAK). Methods. This single-centre case-control study included 53 TAK patients who were matched by age, BMI and sex with 100 healthy individuals. Aside from the patients' general data, the following information was collected: disease activity, level of activities of daily living (HAQ), physical activity levels and chronic fatigue. Results. The TAK patients and healthy individuals were comparable in terms of current age, BMI and sex distribution. The median disease duration of TAK was 13.0 (7.0-20.0) years, and 11 (20.8%) patients had active disease. Compared with healthy individuals, patients with TAK had a higher prevalence of fatigue and lower HAQ score, physical activity level and intensity, and physical and psychosocial domains of the modified fatigue impact scale (P < 0.01). Moreover, TAK patients had increased fatigue rates compared with the healthy individuals (fatigue severity scale: odds ratio = 2.6; 95% CI = 1.2, 5.4; modified fatigue impact scale: odds ratio = 2.6; 95% CI = 1.2, 5.5). Fatigue was positively correlated with worsening HAQ, CRP levels, daily prednisone dose and disease activity, and negatively correlated with disease duration. Conclusion. TAK patients have a higher prevalence of fatigue, which affects different aspects of the disease, including physical function. Thus, fatigue-focused treatments should also be considered in clinical practice.
conferenceObject Coronary inflammation by computed tomography pericoronary fat attenuation in young male anabolic androgenic steroid users(2022) SOUZA, F.; ROCHITTE, C. E.; SILVA, D. C.; GOMES, A. M. R.; SANTOS, M. R.; FONSECA, G. W. P.; BATTAGLIA, A. C. B. F.; CORREA, K. T. S.; YONAMINE, M.; PEREIRA, R. M. R.; NEGRAO, C. E.; ALVES, M. J. N. N.conferenceObject Performance of FRAX (R) Brazil and NOGG Methodology with and Without Bone Mineral Density upon Predicting Fractures on a Community-Dwelling Elderly Population with High Incidence of Osteoporotic Fractures: The Sao Paulo Ageing and Health (SPAH) Study(2022) FREITAS, Thiago Q.; OLALLA, Leonardo F. G.; TAKAYAMA, Liliam; CAPARBO, Valeria; FIGUEIREDO, Camille; MACHADO, Luana; DOMICIANO, Diogo; PEREIRA, Rosa- Lower hand grip in rheumatoid arthritis patients is associated with low finite element analysis using high resolution peripheral quantitative computed tomography scan of the 2nd metacarpophalangeal joint(2022) FIGUEIREDO, Camille Pinto; PEREZ, Mariana Ortega; SALES, Lucas Peixoto; DOMICIANO, Diogo Souza; SAMPAIO-BARROS, Marilia M.; CAPARBO, Valeria de Falco; PEREIRA, Rosa Maria RodriguesAim To evaluate hand function by hand grip test in rheumatoid arthritis (RA) patients, and its association with bone erosions and the estimated bone strength (finite element - FE analysis) through the analysis of the 2nd metacarpal head of the dominant hand using high resolution peripheral quantitative computed tomography (HR-pQCT). Method Eighty-two female RA patients between 18-50 years old were selected. Demographic data, Health Questionnaire Assessment Disability Index (HAQ), Disease Activity Score of 28 joints (DAS)-28, simplified disease activity index (SDAI) and the hand grip test were set. The HR-pQCT scans of 2nd metacarpophalangeal joints of the dominant hand of all patients were performed according to SPECTRA group protocols. The images were used to assess bone erosions and FE analysis. The hand grip test was categorized in 2 groups and separately compared (< 18 vs >= 18 kgf). A logistic regression was performed using hand grip test A significant difference was found between the 2 groups regarding HAQ, inflammatory markers (erythrocyte sedimentation rate, C-reactive protein), DAS-28, SDAI, total volume of erosion and bone strength parameter (FE analysis - Failure Load [F.Load]). The logistic regression analysis showed that the risk factors associated with hand grip test <18 kgf were higher SDAI (odds ratio [OR] 0.912; 95% CI 0.837-0.993) and lower values of bone strength parameter (F.Load) (OR 1.007; 95% CI 1.002-1.012). Conclusion Lower values of hand grip test were associated with higher disease activity score-SDAI and lower bone strength of 2nd metacarpal bone head of the dominant hand evaluated here through a FE analysis using HR-pQCT scan.
conferenceObject CLOSE TO THE BONE: A CASE OF CONCURRENTMULTIFOCAL OSTEONECROSIS AND PERIPHERAL SPONDYLOARTHROPATHY(2022) MACEDO, M. B.; GIARDINI, H. A. M.; GUEDES, L. K. N.; PEREIRA, R. M. R.- Development and Implementation of the AIDA International Registry for Patients with Non-Infectious Scleritis(2022) CASA, Francesca Della; VITALE, Antonio; PEREIRA, Rosa Maria; GUERRIERO, Silvana; RAGAB, Gaafar; LOPALCO, Giuseppe; CATTALINI, Marco; MATTIOLI, Irene; PARRONCHI, Paola; PAROLI, Maria Pia; GIUDICE, Emanuela Del; GAGGIANO, Carla; DAGOSTIN, Marilia A.; ALBANO, Valeria; SOLIMAN, Mahmoud M.; COLELLA, Sergio; NASCIMBENI, Giuseppe; SOTA, Jurgen; ANTONELLI, Isabele P. B.; ALESSIO, Giovanni; CAGGIANO, Valeria; TUFAN, Abdurrahman; AMIN, Rana Hussein; TARSIA, Maria; GHANEMA, Mahmoud; IANNONE, Florenzo; RICCI, Francesca; TORRE, Francesco La; WIESIK-SZEWCZYK, Ewa; CONTICINI, Edoardo; GENTILESCHI, Stefano; DAMMACCO, Rosanna; CIMAZ, Rolando; FREDIANI, Bruno; ABBRUZZESE, Anna; RUSCITTI, Piero; TOSI, Gian Marco; GIORDANO, Heitor F.; CONFORTI, Alessandro; BALISTRERI, Alberto; RIGANTE, Donato; CANTARINI, Luca; FABIANI, ClaudiaIntroduction This article points out the design, methods, development and deployment of the international registry promoted by the AutoInflammatory Disease Alliance (AIDA) Network with the aim to define and assess paediatric and adult patients with immune-mediated scleritis. Methods This registry collects both retrospective and prospective real-world data from patients with non-infectious scleritis through the Research Electronic Data Capture (REDCap) tool and aims to promote knowledge and real-life evidence from patients enrolled worldwide; the registry also allows the collection of standardised data, ensuring the highest levels of security and anonymity of patients' data and flexibility to change according to scientific acquisitions over time. The communication with other similar registries has been also ensured in order to pursue the sustainability of the project with respect to the adaptation of collected data to the most diverse research projects. Results Since the launch of the registry, 99 centres have been involved from 20 countries and four continents. Forty-eight of the centres have already obtained a formal approval from their local ethics committees. At present, the platform counts 259 users (95 principal investigators, 160 site investigators, 2 lead investigators, and 2 data managers); the platform collects baseline and follow-up data using 3683 fields organised into 13 instruments, including patient's demographics, history, symptoms, trigger or risk factors, therapies and healthcare utilization. Conclusions The development of the AIDA International Registry for patients with non-infectious scleritis will allow solid research on this rare condition. Real-world evidence resulting from standardised real-life data will lead to the optimisation of routine clinical and therapeutic management, which are currently limited by the rarity of this ocular inflammatory condition.
- Development and implementation of the AIDA international registry for patients with Schnitzler's syndrome(2022) SOTA, Jurgen; VITALE, Antonio; WIESIK-SZEWCZYK, Ewa; FRASSI, Micol; LOPALCO, Giuseppe; EMMI, Giacomo; GOVONI, Marcello; PAULIS, Amato de; MARINO, Achille; GIDARO, Antonio; MONTI, Sara; OPRIS-BELINSKI, Daniela; PEREIRA, Rosa Maria R.; JAHNZ-ROZYK, Karina; GAGGIANO, Carla; CRISAFULLI, Francesca; IANNONE, Florenzo; MATTIOLI, Irene; RUFFILLI, Francesca; MORMILE, Ilaria; RYBAK, Katarzyna; CAGGIANO, Valeria; AIRO, Paolo; TUFAN, Abdurrahman; GENTILESCHI, Stefano; RAGAB, Gaafar; ALMAGHLOUTH, Ibrahim A.; KHALIL, Adham Aboul-Fotouh; CATTALINI, Marco; TORRE, Francesco La; TARSIA, Maria; GIARDINI, Henrique A. Mayrink; SAAD, Moustafa Ali; BOCCHIA, Monica; CARONI, Federico; GIANI, Teresa; CINOTTI, Elisa; RUSCITTI, Piero; RUBEGNI, Pietro; DAGOSTIN, Marilia A.; FREDIANI, Bruno; GULER, Aslihan Avanoglu; CASA, Francesca Della; MAGGIO, Maria Cristina; RECKE, Andreas; BUBNOFF, Dagmar von; KRAUSE, Karoline; BALISTRERI, Alberto; FABIANI, Claudia; RIGANTE, Donato; CANTARINI, LucaObjective: The present paper describes the design, development, and implementation of the AutoInflammatory Disease Alliance (AIDA) International Registry specifically dedicated to patients with Schnitzler's syndrome. Methods: This is a clinical physician-driven, population- and electronic-based registry implemented for the retrospective and prospective collection of real-life data from patients with Schnitzler's syndrome; the registry is based on the Research Electronic Data Capture (REDCap) tool, which is designed to collect standardized information for clinical research, and has been realized to change over time according to future scientific acquisitions and potentially communicate with other existing or future similar registries. Results: Since its launch, 113 centers from 23 countries in 4 continents have been involved. Fifty-seven have already obtained the approval from their local Ethics Committees. The platform counts 324 users (114 Principal Investigators, 205 Site Investigators, 2 Lead Investigators, and 3 data managers) at current (April 28th, 2022). The registry collects baseline and follow-up data using 3,924 fields organized into 25 instruments, including patient's demographics, history, clinical manifestations and symptoms, trigger/risk factors, laboratory, instrumental exams, therapies, socioeconomic information, and healthcare access. Conclusions: This International Registry for patients with Schnitzler's syndrome facilitates standardized data collection, enabling international collaborative projects through data sharing and dissemination of knowledge; in turn, it will shed light into many blind spots characterizing this complex autoinflammatory disorder.