ROSA MARIA RODRIGUES PEREIRA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
19 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 19
conferenceObject Performance of FRAX® Brazil and NOGG Methodology with and Without Bone Mineral Density upon Predicting Fractures on a Community-Dwelling Elderly Population with High Incidence of Osteoporotic Fractures - The Sao Paulo Ageing and Health (SPAH) Study(2023) FREITAS, Thiago Q.; OLALLA, Leonardo F. Guerron; TAKAYAMA, Liliam; CAPARBO, Valeria F.; FIGUEIREDO, Camille P.; MACHADO, Luana G.; DOMICIANO, Diogo S.; PEREIRA, Rosa M. R.conferenceObject Association between Metabolic Syndrome and Bone Mineral Density in a Community-dwelling Older Women: the Sao Paulo Ageing & Health Study (SPAH)(2013) MACHADO, Luana; DOMICIANO, Diogo; LOPES, Jaqueline; FIGUEIREDO, Camille; CAPARBO, Valeria; TAKAYAMA, Liliam; PEREIRA, RosaconferenceObject Healing of Tumor-Induced Osteomalacia as Assessed by HR-pQCT is Not Similar Across the Peripheral Skeletal Sites in the First Years Following Complete Tumor Excision(2023) ROSA NETO, Nilton Salles; PEREIRA, Rosa Maria; YUKI, Emily Figueiredo Neves; SOUZA, Fernando Henrique Carlos de; TAKAYAMA, Liliam; ISHY, Augusto; CARNEIRO, Maria Inez da Silveira; LIMA, Luiz Guilherme Cernaglia Aureliano de; ELIAS, Alexandre Jose ReisconferenceObject Smoking effects in bone tissue in patients with advanced stages of osteoarthritis(2022) KOHLER, Julia; FERREIRA, Alex; NUNES, Walleson; FIALHO, Barbara; NEVES, Marco Aurelio; LIMA, Leandro; TEODORO, Walcy; PEREIRA, Rosa; TIBERIO, Iolanda; BARBOSA, Alexandre; LOPES, Fernanda Degobbi- Treatment of Human Immunodeficiency Virus Infection With Tenofovir Disoproxil Fumarate-Containing Antiretrovirals Maintains Low Bone Formation Rate, But Increases Osteoid Volume on Bone Histomorphometry(2019) RAMALHO, Janaina; MARTINS, Carolina Steller Wagner; GALVAO, Juliana; FURUKAWA, Luzia N.; DOMINGUES, Wagner V.; OLIVEIRA, Ivone B.; REIS, Luciene M. dos; PEREIRA, Rosa M. R.; NICKOLAS, Thomas L.; YIN, Michael T.; EIRA, Margareth; JORGETTI, Vanda; MOYSES, Rosa M. A.Bone mineral density (BMD) loss is a known complication of human immunodeficiency virus (HIV) infection and its treatment, particularly with tenofovir disoproxil fumarate (TDF)-containing antiretroviral regimens. Although renal proximal tubular dysfunction and phosphaturia is common with TDF, it is unknown whether BMD loss results from inadequate mineralization. We evaluated change in BMD by dual-energy X-ray absorptiometry (DXA) and bone histomorphometry by tetracycline double-labeled transiliac crest biopsies in young men living with HIV before (n = 20) and 12 months after (n = 16) initiating TDF/lamivudine/efavirenz. We examined relationships between calciotropic hormones, urinary phosphate excretion, pro-inflammatory and pro-resorptive cytokines, and bone remodeling-related proteins with changes in BMD and histomorphometry. Mean age was 29.6 +/- 5.5 years, with mean CD4 + T cell count of 473 +/- 196 cells/mm(3). At baseline, decreased bone formation rate and increased mineralization lag time were identified in 16 (80%) and 12 (60%) patients, respectively. After 12 months, we detected a 2% to 3% decrease in lumbar spine and hip BMD by DXA. By histomorphometry, we observed no change in bone volume/total volume (BV/TV) and trabecular parameters, but rather, increases in cortical thickness, osteoid volume, and osteoblast and osteoclast surfaces. We did not observe significant worsening of renal phosphate excretion or mineralization parameters. Increases in PTH correlated with decreased BMD but not histomorphometric parameters. Overall, these data suggest abnormalities in bone formation and mineralization occur with HIV infection and are evident at early stages. With TDF-containing antiretroviral therapy (ART), there is an increase in bone remodeling, reflected by increased osteoblast and osteoclast surfaces, but a persistence in mineralization defect, resulting in increased osteoid volume. (c) 2019 American Society for Bone and Mineral Research
conferenceObject Parathyroid Hormone and Bone Mineral Density as Independent Risk Factors for Mortality in Community-Dwelling Older Adults: the Sao Paulo Ageing & Health Study (SPAH)(2013) DOMICIANO, Diogo; MACHADO, Luana; FIGUEIREDO, Camille; LOPES, Jaqueline; CAPARBO, Valeria; TAKAYAMA, Liliam; BONFA, Eloisa; PEREIRA, RosaconferenceObject Fabry disease: elevated prevalence of vertebral fractures and correlation with Mainz Severity Score Index(2019) ROSA NETO, Nilton Salles; BENTO, Judith Campos de Barros; TAKAYAMA, Liliam; CAPARBO, Valeria de Falco; PEREIRA, Rosa Maria Rodrigues- Association of Appendicular Lean Mass, and Subcutaneous and Visceral Adipose Tissue With Mortality in Older Brazilians: The Sao Paulo Ageing & Health Study(2019) SANTANA, Felipe M. de; DOMICIANO, Diogo S.; GONCALVES, Michel A.; MACHADO, Luana G.; FIGUEIREDO, Camille P.; LOPES, Jaqueline B.; CAPARBO, Valeria F.; TAKAYAMA, Lilliam; MENEZES, Paulo R.; PEREIRA, Rosa M. R.Body composition changes as a result of ageing may impact the survival of older adults. However, its influence on mortality risk is uncertain. Currently, the best method for body composition analysis in clinical practice is DXA. Nonetheless, the few studies on body composition by DXA and mortality risk in the elderly have some limitations. We investigated the association between body composition by DXA and mortality in a cohort of elderly subjects. Eight hundred thirty-nine community-dwelling subjects (516 women, 323 men) >= 65 years of age were assessed by a questionnaire, clinical data, laboratory exams, and body composition by DXA at baseline. Total fat and its components (eg, visceral adipose tissue [VAT]) were estimated. Appendicular lean mass (ALM) adjusted for fat and ALM divided by height(2) was used to ascertain the presence of low muscle mass (LMM). Mortality was recorded during follow-up. Multivariate logistic regression was used to compute ORs for all-cause and cardiovascular mortality. Over a mean follow-up of 4.06 +/- 1.07 years, there were 132 (15.7%) deaths. In men, after adjustment for relevant variables, the presence of LMM (OR, 11.36, 95% CI, 2.21 to 58.37, P = 0.004) and VAT (OR, 1.99, 95% CI, 1.38 to 2.87, P < 0.001, for each 100-g increase) significantly increased all-cause mortality risk, whereas total fat, measured by the fat mass index, was associated with decreased mortality risk (OR, 0.48, 95% CI, 0.33 to 0.71, P < 0.001). Similar results were observed for cardiovascular mortality. In women, only LMM was a predictor of all-cause (OR, 62.88, 95% CI, 22.59 to 175.0, P < 0.001) and cardiovascular death (OR, 74.54, 95% CI, 9.72 to 571.46, P < 0.001). LMM ascertained by ALM adjusted for fat and fat mass by itself are associated with all-cause and cardiovascular mortality risk in the elderly. Visceral and subcutaneous fat have opposite roles on mortality risk in elderly men. Thus, DXA is a promising tool to estimate risk of mortality in the elderly. (c) 2019 American Society for Bone and Mineral Research.
- Bone Mineral Density and Parathyroid Hormone as Independent Risk Factors for Mortality in Community-Dwelling Older Adults: A Population-Based Prospective Cohort Study in Brazil. The SAo Paulo Ageing & Health (SPAH) Study(2016) DOMICIANO, Diogo S.; MACHADO, Luana G.; LOPES, Jaqueline B.; FIGUEIREDO, Camille P.; CAPARBO, Valeria F.; OLIVEIRA, Ricardo M.; SCAZUFCA, Marcia; MCCLUNG, Michael R.; PEREIRA, Rosa M. R.Previous studies have shown a relationship between osteoporosis and increased mortality risk. However, none of these studies performed a concomitant evaluation of the parathyroid hormone (PTH)-calcium-vitamin D axis and bone mass to accurately determine the contribution of each of these parameters to survival in older subjects. Thus, we sought to investigate the association between bone parameters and mortality in a longitudinal, prospective, population-based cohort of 839 elderly subjects. Clinical data (including history of fractures and cardiovascular events) were assessed using a specific questionnaire. Laboratory exams, including serum 25OHD and PTH, were also performed. Bone mineral density (BMD) at the lumbar spine and hip were evaluated using DXA. All analyses were performed at baseline (2005 to 2007). Mortality was recorded during follow-up. Multivariate Cox proportional regression was used to compute hazard ratios for all-cause and cardiovascular mortality. Over a mean 4.06 +/- 1.07 years, there were 132 (15.7%) deaths. These individuals were compared to 707 subjects who were alive at the end of the coverage period for mortality data collection. In a multivariate Cox proportional hazards model, age (HR 1.32; 95% CI, 1.13 to 1.55; p=0.001, for each 5-year increase), male gender (HR 1.90; 95% CI, 1.30 to 2.79; p=0.001), recurrent falls (more than two in the previous year; HR 1.65; 95% CI, 1.06 to 2.56; p=0.026), diabetes mellitus (HR 2.17; 95% CI, 1.46 to 3.21; p<0.001), low physical activity score (HR 1.78; 95% CI, 1.14 to 2.79; p=0.011), prior cardiovascular event (HR 1.76; 95% CI, 1.18 to 2.63; p=0.006), total hip BMD (HR 1.41; 95% CI, 1.15 to 1.72; p=0.001, per each 1 SD decrease), and intact PTH (iPTH) (HR 1.06; 95% CI, 1.04 to 1.08; p<0.001, per each 10pg/mL increase) were independently associated with all-cause mortality. The subjects in the highest quartile of PTH (>49pg/mL) were at a higher risk of cardiovascular death (HR 3.09; 95% CI, 1.36 to 6.99; p=0.007) compared with the subjects in the lowest quartile (<26pg/mL). Low BMD and higher PTH were significantly associated with mortality in community-dwelling older adults. These findings support the notion that careful screening of these bone parameters might lead to better management of older patients and improve outcomes in this population. (c) 2016 American Society for Bone and Mineral Research.
conferenceObject A Local Microstructure and Mechanical Properties Assessment By Volume Reduction of Human Vertebral Trabecular Bone Using HR-pQCT and FEA(2019) SILVA, Alessandro; CARVALHO, Jonas De; LAZARETTI-CASTRO, Marise; PEREIRA, Rosa M. R.