LUCIANA ALVARENGA DA SILVA
Projetos de Pesquisa
Unidades Organizacionais
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
11 resultados
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- Sensorial differences according to sex and ages(2014) SILVA, L. A. da; LIN, S. M.; TEIXEIRA, M. J.; SIQUEIRA, J. T. T. de; JACOB FILHO, W.; SIQUEIRA, S. R. D. T. deObjective To investigate age and sex differences in orofacial sensory detection. Methods One hundred and twenty-six (126) healthy subjects were divided into five groups according to their ages. They were assessed with a quantitative sensory testing protocol for gustative, olfactory, thermal (cold/warm), mechanical (tactile/vibration/electric), and pain (deep/superficial) detection thresholds. The corneal reflex was also evaluated. Data were analyzed with the one-way ANOVA, chi-squared, Fisher's exact, Mann-Whitney, and Kruskal-Wallis tests. Results The groups of subjects over 61years old had higher olfactory (P<0.001), gustative (sweet P=0.004, salty P=0.007, sour P=0.006), thermal (warm P<0.001, cold P<0.001), and tactile (P<0.001) detection thresholds than the others. The vibration detection threshold was high only for subjects over 75years old (P<0.001). The electric and deep pain detection thresholds were different for the 61-75years old group (P <= 0.001). Women in all age groups had lower gustative (sweet P=0.020, salty P=0.002, sour P<0.001, and bitter P=0.002), olfactory (P=0.010), warm (P<0.001) and deep (P<0.001), and superficial pain (P=0.008) detection thresholds than men, and men from all age groups had lower vibratory detection thresholds (P=0.006) than women. Conclusion High sensory detection thresholds were observed in subjects over the 6th decade of life, and women had a more accurate sensory perception than men.
- Facial somatosensorial evaluation in idiopathic trigeminal neuralgia(2012) SILVA, Luciana Alvarenga da; SIQUEIRA, Silvia Regina Dowgan Tesseroli de; SIQUEIRA, Jose Tadeu Tesseroli de; TEIXEIRA, Manoel Jacobsen
conferenceObject Subthalamic Deep Brain Stimulation Modulates Small-Fiber Dependent Sensory Thresholds in Parkinson's Disease(2012) ANDRADE, Daniel Ciampi De; LEFAUCHEUR, Jean-Pascal; GALHARDONI, Ricardo; FERREIRA, Karine; PAIVA, Anderson de; BOHR-SENG-SHU, Edson; ALVARENGA, Luciana; MYCZKOWSKI, Martin; MARCOLIN, Marco; SIQUEIRA, Silvia de; FONOFF, Erich; BARBOSA, Egberto; TEIXEIRA, Manoel- Functional and sensory evaluation of patients with idiopathic trigeminal neuralgia: Comparison with controls(2015) ICHIDA, Michelle Cristina; SILVA, Luciana Alvarenga da; TEIXEIRA, Manoel Jacobsen; SIQUEIRA, Jose Tadeu Tesseroli de; SIQUEIRA, Silvia R. D. T. deBackground: Idiopathic trigeminal neuralgia (ITN) can be associated with orofacial and sensory comorbidities. Objective: To evaluate the masticatory functional and sensory characteristics of patients with ITN compared with controls. Methods: We enrolled 119 patients and 30 healthy controls. They were evaluated with a systematic protocol: clinical orofacial evaluation questionnaire; a systematic approach of the mandibular function and the investigation of musculoskeletal comorbidities by the research diagnostic criteria for temporomandibular disorders (RDC/TMD) and the Helkimo indexes; and quantitative sensory testing (corneal reflex and gustative, olfactory, thermal, mechanical and pain thresholds). Results: The study group had more loss of vertical dimension than the controls (p = 0.011) and restriction of the maximum mouth opening (p = 0.024); they had more pain on mandibular movements (p = 0.001), limitation of mandibular function (p < 0.001), masticatory discomfort (p < 0.001) and myofascial pain (p = 0.001). Occlusion Helkimo index was lower in controls than patients. The study group had high tactile (p = 0.025), warm (p = 0.020) and cold (p = 0.003) thresholds. Conclusion: ITN may cause severe mandibular limitations that can be associated with the pain episodes and with sensory abnormalities. These findings indicate the affection of small and large nerve fibers and support the neuropathic nature of ITN. Sensory alterations can be part of the natural history of ITN and can be associated with the previous treatments including medication. They cause a high impact in quality of life.
- The role of xerostomia in burning mouth syndrome: a case-control study(2014) SILVA, Luciana Alvarenga da; SIQUEIRA, Jose Tadeu Tesseroli de; TEIXEIRA, Manoel Jacobsen; SIQUEIRA, Silvia Regina Dowgan Tesseroli deObjective : To assess the efficacy of anti-xerostomic topical medication (urea 10%) in patients with burning mouth syndrome (BMS). Method : Thirty-eight subjects diagnosed with BMS according to the International Association for the Study of Pain guidelines were randomized to either placebo (5% sodium carboxymethylcellulose, 0.15% methyl paraben, and 10% glycerol in distilled water qsp 100 g) or treatment (urea 10%) to be applied to the oral cavity 3-4 times per day for 3 months. The patients were evaluated before and after treatment with the following instruments: the EDOF-HC protocol (Orofacial Pain Clinic – Hospital das Clínicas), a xerostomia questionnaire, and quantitative sensory testing. Results : There were no differences in salivary flow or gustative, olfactory, or sensory thresholds (P>0.05). Fifteen (60%) patients reported improvement with the treatments (P=0.336). Conclusion : In conclusion, there were no differences between groups, and both exhibited an association between reported improvement and salivation.
- High prevalence of orofacial complaints in patients with fibromyalgia: a case-control study(2012) SILVA, Luciana A. da; KAZYIAMA, Helena H.; SIQUEIRA, Jose T. T. de; TEIXEIRA, Manoel J.; SIQUEIRA, Silvia R. D. T. deObjective. The aim of this study was to investigate the orofacial complaints and characteristics of patients with fibromyalgia syndrome (FS) compared with controls. Study Design. We evaluated 25 patients diagnosed with FS compared with 25 gender-and age-matched controls by using a detailed clinical protocol for orofacial pain diagnosis and dental examination. Results. FS patients had a higher frequency of temporomandibular disorders (TMD), masticatory complaints, pain with mandibular movements, and pain upon palpation of the head and neck area. There were no significant differences related to the dental exam. Conclusions. Orofacial complaints including TMD may be present either as symptoms of FS or as a comorbidity associated with this condition. A comprehensive evaluation of patients with FS is necessary to identify the need for specific treatments for orofacial complaints. Future studies, especially those with longitudinal design, should clarify whether a cause-effect relationship exists between orofacial complaints and fibromyalgia. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:e29-e34)
- Quantitative sensory testing in fibromyalgia and hemisensory syndrome: comparison with controls(2013) SILVA, Luciana Alvarenga da; KAZYIAMA, Helena Hideko Seguchi; TEIXEIRA, Manoel Jacobsen; SIQUEIRA, Silvia Regina Dowgan Tesseroli deFibromyalgia syndrome (FS) is a chronic painful condition with sensory, motor and affective dysfunctions. Few studies had investigated the trigeminal area, and little is known about its association with hemisensory syndrome, which is characterized by chronic pain restricted to hemibody. Our objective was to investigate sensorial abnormalities with quantitative sensory testing of patients with FS and patients with hemisensory syndrome, compared to controls. Thirteen patients diagnosed with FS according to the American College of Rheumatology, and 12 patients with hemisensory syndrome were evaluated and compared to 25 age-gender-matched controls. They were investigated with a quantitative sensory testing protocol including gustative, olfactory, cold, warm, touch, vibration, electric, deep and superficial pain thresholds and the corneal reflex evaluation. The patients had higher gustative thresholds for salty and bitter. In general, patients with FS had somatosensory thresholds higher than the controls; however, patients with hemisensory syndrome had only superficial pain thresholds increased, in both body sides and not only in the area affected by pain. Patients with hemisensory syndrome can be a subgroup of FS, different from nondermatomal somatosensory deficits which are characterized by chronic pain with hypoesthesia in hemibody. The bilateral hypoalgesia supports that pain pathways play a key role in this condition, with no compromise of other sensorial modalities.
- Subthalamic deep brain stimulation modulates small fiber-dependent sensory thresholds in Parkinson's disease(2012) ANDRADE, Daniel Ciampi de; LEFAUCHEUR, Jean-Pascal; GALHARDONI, Ricardo; FERREIRA, Karine S. L.; PAIVA, Anderson Rodrigues Brandao; BOR-SENG-SHU, Edson; ALVARENGA, Luciana; MYCZKOWSKI, Martin L.; MARCOLIN, Marco Antonio; SIQUEIRA, Silvia R. D. T. de; FONOFF, Erich; BARBOSA, Egberto Reis; TEIXEIRA, Manoel JacobsenThe effects of deep brain stimulation of the subthalamic nucleus on nonmotor symptoms of Parkinson's disease (PD) rarely have been investigated. Among these, sensory disturbances, including chronic pain (CP), are frequent in these patients. The aim of this study was to evaluate the changes induced by deep brain stimulation in the perception of sensory stimuli, either noxious or innocuous, mediated by small or large nerve fibers. Sensory detection and pain thresholds were assessed in 25 PD patients all in the off-medication condition with the stimulator turned on or off (on- and off-stimulation conditions, respectively). The relationship between the changes induced by surgery on quantitative sensory testing, spontaneous CP, and motor abilities were studied. Quantitative sensory test results obtained in PD patients were compared with those of age-matched healthy subjects. Chronic pain was present in 72% of patients before vs 36% after surgery (P = .019). Compared with healthy subjects, PD patients had an increased sensitivity to innocuous thermal stimuli and mechanical pain, but a reduced sensitivity to innocuous mechanical stimuli. In addition, they had an increased pain rating when painful thermal stimuli were applied, particularly in the off-stimulation condition. In the on-stimulation condition, there was an increased sensitivity to innocuous thermal stimuli but a reduced sensitivity to mechanical or thermal pain. Pain provoked by thermal stimuli was reduced when the stimulator was turned on. Motor improvement positively correlated with changes in warm detection and heat pain thresholds. Subthalamic nucleus deep brain stimulation contributes to relieve pain associated with PD and specifically modulates small fiber-mediated sensations.
- Quantitative sensory testing in elderly: longitudinal study(2018) SILVA, Luciana Alvarenga da; JALUUL, Omar; TEIXEIRA, Manoel Jacobsen; SIQUEIRA, Jose Tadeu Tesseroli de; JACOB FILHO, Wilson; SIQUEIRA, Silvia Regina Dowgan Tesseroli deObjective: To evaluate elderly patients in a geriatric service, along with their sensory characteristics and their association with clinical aspects. Methods: This was a descriptive longitudinal study. We enrolled 36 healthy participants of both sexes in this study. The following instruments were used and evaluations performed: clinical evaluation, Mini-Mental State Exam, and quantitative sensory testing. Results: During the follow-up, there was reduction of mean corpuscular volume at each evaluation (p < 0.001) and significant increase in mean corpuscular hemoglobin concentration (p < 0.001). There was an increase of the olfactory (p < 0.001), salty (p = 0.024), sour (p = 0.020), bitter (p = 0.001), facial cold (p = 0.019), hand cold (p = 0.004), facial tactile (p < 0.001), hand tactile (p = 0.012) and facial vibration (p = 0.018) thresholds. Previous existing morbidities were associated with sensitivity changes in the individuals in this sample. Conclusion:This longitudinal study suggests that the loss of sensitivity with aging may be associated with the presence of morbidities in elders.
conferenceObject Subthalamic deep brain stimulation modulates small-fiber dependent sensory thresholds in Parkinson's disease(2012) ANDRADE, D. C.; LEFAUCHEUR, J. P.; GALHARDONI, R.; PAIVA, A.; BOHR-SENG-SHU, E.; BRANT, R.; MYCZKOWSKI, M.; ALVARENGA, L.; FERREIRA, K.; SOUZA, C.; SIQUEIRA, S.; MARCOLIN, M. A.; FONOFF, E.; BARBOSA, E. R.; JACOBSEN, M.