PAOLO JOSE CESARE BISELLI
Projetos de Pesquisa
Unidades Organizacionais
SCPACIN-62, Hospital Universitário
2 resultados
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- Lung Mechanics Over the Century: From Bench to Bedside and Back to Bench(2022) BISELLI, Paolo Jose Cesare; LOPES, Fernanda Degobbi Tenorio Quirino Dos Santos; RIGHETTI, Renato Fraga; MORIYA, Henrique Takachi; TIBERIO, Iolanda Ftima Lopes Calvo; MARTINS, Milton ArrudaLung physiology research advanced significantly over the last 100 years. Respiratory mechanics applied to animal models of lung disease extended the knowledge of the workings of respiratory system. In human research, a better understanding of respiratory mechanics has contributed to development of mechanical ventilators. In this review, we explore the use of respiratory mechanics in basic science to investigate asthma and chronic obstructive pulmonary disease (COPD). We also discuss the use of lung mechanics in clinical care and its role on the development of modern mechanical ventilators. Additionally, we analyse some bench-developed technologies that are not in widespread use in the present but can become part of the clinical arsenal in the future. Finally, we explore some of the difficult questions that intensive care doctors still face when managing respiratory failure. Bringing back these questions to bench can help to solve them. Interaction between basic and translational science and human subject investigation can be very rewarding, as in the conceptualization of ""Lung Protective Ventilation"" principles. We expect this interaction to expand further generating new treatments and managing strategies for patients with respiratory disease.
- Analysis of respiratory mechanics in animal models: Its use in understanding lung behavior in emphysema and asthma(2019) BISELLI, P.J.C.; KOHLER, J. Benini; RIGHETTI, R.; TIBéRIO, I. de Fátima Lopes Calvo; MARTINS, M. de Arruda; LOPES, F. Degobbi Tenorio Quirino dos SantosRespiratory mechanics assessment in animal models of respiratory diseases is considered a reliable tool to understand how structural changes impact lung function. Mathematical models, such as the equation of motion and the constant-phase model are used to describe the properties of the respiratory system. The equation of motion is valued because it is relatively simple to apply and describes the respiratory systems with few parameters. The constant-phase model is more complex but provides more detailed information about different lung compartments. In this review, we summarize how respiratory mechanics have been used to describe lung behavior as well as how these measurements reflect the progression of structural changes caused by emphysema and asthma in animal models. © 2019 Elsevier Ltd