PEDRO NOGUEIRA GIGLIO

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PAHC, Hospital das Clínicas, Faculdade de Medicina - Médico

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Autor e Coautores FMUSP-HC Normalizados: ALEXANDRE LEME GODOY DOS SANTOS ×

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  • article 21 Citação(ões) na Scopus
    Cartilage lesions and ankle osteoarthrosis: review of the literature and treatment algorithm,
    (2014) SANTOS, Alexandre Leme Godoy; DEMANGE, Marco Kawamura; PRADO, Marcelo Pires; FERNANDES, Tulio Diniz; GIGLIO, Pedro Nogueira; HINTERMANN, Beat
    The main etiology of ankle osteoarthrosis is post-traumatic and its prevalence is highest amongyoung individuals. Thus, this disease has a great socioeconomic impact and gives rise to significant losses of patients' quality of life. The objective of its treatment is to eliminate pain and keep patients active. Therefore, the treatment should be staged according to the degree of degenerative evolution, etiology, joint location, systemic condition, bone quality, lower-limb alignment, ligament stability and age. The treatment algorithm is divided into non-surgical therapeutic methods and options for surgical treatment. Joint preservation, joint replacement and arthrodesis surgical procedures have precise indications. This article presents a review on this topic and a proposal for a treatment algorithm for this disease.
  • article 0 Citação(ões) na Scopus
    Combined Anterior Cruciate Ligament and Anterolateral Ligament Reconstruction Using a Single Peroneus Longus Tendon Graft
    (2024) SILVA, Andre Giardino Moreira da; MACEDO, Rodrigo Sousa; SOUZA, Michel Oliveira; GIGLIO, Pedro Nogueira; VIDEIRA, Livia Dau; GOBBI, Riccardo Gomes; SANTOS, Alexandre Leme Godoy dos; HELITO, Camilo Partezani
    The peroneus longus tendon seems a viable graft option for knee ligament reconstructions, with adequate biomechanical properties and low morbidity after harvesting. The objective of this article is to describe a combined anterior cruciate ligament and anterolateral ligament reconstruction technique using a single peroneus longus tendon graft harvested from the infra malleolar region to ensure sufficient length.
  • article 14 Citação(ões) na Scopus
    Increased cytokine levels and histological changes in cartilage, synovial cells and synovial fluid after malleolar fractures
    (2017) GODOY-SANTOS, Alexandre L.; RANZONI, Lucas; TEODORO, Walcy R.; CAPELOZZI, Vera; GIGLIO, Pedro; DINIZ-FERNANDES, Tulio; RAMMELT, Stefan
    Background: Malleolar fractures are among the most common fractures in the human skeleton with a high risk of later development of post-traumatic osteoarthritis (OA). The acute ankle injury initiates a sequence of events potentially leading to progressive articular surface damage resulting from inflammatory changes in cartilage, synovial tissue and synovial fluid. We hypothesised that in the acute phase of ankle fracture, these changes occur at the same time in the different tissues. Methods: Specimens of chondral tissue, synovial tissue and synovial fluid were collected from 16 patients with acute articular ankle fracture (study group). Additional samples were obtained from five male fresh cadavers within 12 hours of death (control group). Chondral tissue was assessed for cellularity, irregularities and chondrocyte disarray. Synovial tissue was assessed for synovitis, proteoglycans and collagen deposition. Synovial fluid was assessed for cytokines IL-2, IL-6, IL-10, IL-17, IFN-7 and TGF-beta 1. Results: Chondral tissue showed discontinuity in the tidemark between cartilage and subchondral bone, chondrocyte disarray, increased cellularity (both at the cartilage surface and subchondral bone), articular surface irregularities and increased deposition of proteoglycans and collagen fibres. Synovial tissue showed a statistically significant difference between the study and control groups in the concentration per tissue area of both thin collagen fibres (p=0.0274) and thick collagen fibres (p<0.0001). Cytokine concentrations in synovial fluid samples were significantly higher in ankle fracture tissue compared with controls for IL-2 (p=0.0002), IL-6 (p< 0.0001), IL-10 (p=0.002) and IL-17 (p< 0.0001). No statistically significant differences were observed for IFN-gamma, (p= 0.06303) and TGF-beta 1 (p= 0.8832). Conclusion: We observed a pattern of simultaneous and interrelated pathological changes in cartilage, subchondral bone, synovial tissue and synovial fluid after acute malleolar fracture. As the observed inflammatory changes could lead to the development of OA, a more thorough knowledge of these early processes could be helpful to find strategies for prevention or delay of this common complication.