PEDRO NOGUEIRA GIGLIO
Projetos de Pesquisa
Unidades Organizacionais
PAHC, Hospital das Clínicas, Faculdade de Medicina - Médico
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- AUTOLOGOUS CHONDROCYTE IMPLANTATION IN BRAZIL(2020) GIGLIO, Pedro Nogueira; LIZIER, Nelson Foresto; LEVY, Debora; SOBRADO, Marcel Faraco; GOBBI, Riccardo Gomes; PECORA, Jose Ricardo; BYDLOWSKI, Sergio Paulo; DEMANGE, Marco KawamuraObjective: To describe the first series of cases of autologous chondrocyte implantation (ACI) in collagen membrane performed in Brazil. Methods: ACI was performed in 12 knees of 11 patients, aged 32.1 +/- 10.9 years, with 5.3 +/- 2.6 cm(2) full-thickness knee cartilage lesions, with a six-month minimum follow-up. Two surgical procedures were performed: arthroscopic cartilage biopsy for isolation and expansion of chondrocytes, which were seeded onto collagen membrane and implanted in the lesion site; the characterization of cultured cells and implant was performed using immunofluorescence for type II collagen (COL2) for cell viability and electron microscopy of the implant. Clinical safety, KOOS and IKDC scores and magnetic resonance imaging were evaluated. We used repeated-measures ANOVA and post-hoc comparisons at alpha = 5%. Results: COL2 was identified in the cellular cytoplasm, cell viability was higher than 95% and adequate distribution and cell adhesion were found in the membrane. The median follow-up was 10.9 months (7 to 19). We had two cases of arthrofibrosis, one of graft hypertrophy and one of superficial infection as complications, but none compromising clinical improvement. KOOS and IKDC ranged from 71.2 +/- 11.44 and 50.72 +/- 14.10, in preoperative period, to 85.0 +/- 4.4 and 70.5 +/- 8.0, at 6 months (p = 0.007 and 0.005). MRI showed regenerated tissue compatible with hyaline cartilage. Conclusion: ACI in collagen membrane was feasible and safe in a short-term follow- up, presenting regenerated formation visualized by magnetic resonance imaging and improved clinical function.
- The use of negative-pressure wound therapy after total knee arthroplasty is effective for reducing complications and the need for reintervention(2020) HELITO, Camilo Partezani; SOBRADO, Marcel Faraco; GIGLIO, Pedro Nogueira; BONADIO, Marcelo Batista; PECORA, Jose Ricardo; DEMANGE, Marco Kawamura; GOBBI, Riccardo GomesBackground Wound healing complications are causal factors of prosthesis infection and poor postoperative evolution of patients after total knee arthroplasty (TKA). Negative-pressure wound therapy (NPWT) can be an option to minimize these complications. The aim of this study is to compare the complications of patients undergoing TKA who used a portable NPWT device in the immediate postoperative period with those of a control group. Methods A total of 296 patients were evaluated. Patients were divided into two groups: those who used NPWT for seven days in the postoperative period (Group 1 - prospective evaluated) and those who used conventional dressings (Group 2 - historical control group). Epidemiological data, comorbidities, local parameters related to the surgical wound and complications were evaluated. Results The groups did not differ in regard to sex, age and clinical comorbidities. Overall, 153 (51.7%) patients had at least one risk factor for wound complications. Patients who used NPWT had a lower rate of complications (28.5% vs. 45.7%,p = 0.001) and a lower rate of reintervention in the operating room (2% vs. 8.5%, p = 0.001). Patients in group 1 had a lower incidence of hyperaemia (14.7% vs. 40.2%,p = 0.01), skin necrosis (2.1% vs. 8.5%,p = 0.04) and wound dehiscence (3.1% vs 10.1%,p = 0.03). The use of NPWT was a protective factor for the presence of complications, with an odds ratio of 0.36 (95% CI 0.206-0.629). Conclusion The number of complications related to the wound after TKA is high; however, most of them are minor and have no impact on the treatment and clinical evolution of patients. The use of NPWT decreased the number of surgical wound complications, especially hyperaemia, dehiscence and necrosis, and reduced the need for reintervention.
- ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY(2020) LEITE, Chilan Bou Ghosson; RANZONI, Lucas Verissimo; GIGLIO, Pedro Nogueira; BONADIO, Marcelo Batista; MELO, Lucas Da Ponte; DEMANGE, Marco Kawamura; GOBBI, Riccardo GomesObjective: To evaluate the profile of blood loss and blood transfusions after the introduction of Tranexamic acid (TXA) in a tertiary university hospital in Brazil. Methods: 173 patients were retrospectively divided into two groups: the ones who received TXA and the control group. Hemoglobin levels (Hb), drain output, transfusion rates, and thromboembolic events were measured. Results: Among the patients included in this study, 82 cases received TXA. Blood transfusion occurred in 3 cases of the TXA group (3.7%), and in 27 control group cases (29.7%; p < 0.001). The average Hb decrease was 2.7 g/dl (+/- 1.39) and the median drain output was 270 mL in the TXA group. In the control group, the values were 3.41 g/dl (+/- 1.34; p < 0.001) and 460 mL (p < 0.001), respectively. Thromboembolic events occurred in 2 TXA group cases (2.4%) and in 3 control group cases (3.3%; p > 0.999). Conclusion: TXA was effective in reducing blood transfusion rates, Hb decrease, and drain output on the 1st postoperative day without increasing thromboembolic events.
- Bacteria drug resistance profile affects knee and hip periprosthetic joint infection outcome with debridement, antibiotics and implant retention(2020) RUDELLI, Bruno Alves; GIGLIO, Pedro Nogueira; CARVALHO, Vladimir Cordeiro de; PECORA, Jose Ricardo; GURGEL, Henrique Melo Campos; GOBBI, Ricardo Gomes; VICENTE, Jose Riccardo Negreiros; LIMA, Ana Lucia Lei Munhoz; HELITO, Camilo PartezaniBackground Evaluate the effect of bacteria drug resistance profile on the success rates of debridement, antibiotics and implant retention. Methods All early acute periprosthetic infections in hip and knee arthroplasties treated with DAIR at our institution over the period from 2011 to 2015 were retrospectively analyzed. The success rate was evaluated according to the type of organism identified in culture: multidrug-sensitive (MSB), methicillin-resistantStaphylococcus aureus(MRSA), multidrug-resistant Gram-negative bacteria (MRB) and according to other risk factors for treatment failure. The data were analyzed using univariate and multivariate statistics. Results Fifty-seven patients were analyzed; there were 37 in the multidrug-sensitive bacteria (MSB) group, 11 in the methicillin-resistantStaphylococcus aureus(MRSA) group and 9 in the other multidrug-resistant Gram-negative bacteria (MRB) group. There was a statistically significant difference (p < 0.05) in the treatment failure rate among the three groups: 8.3% for the MSB group, 18.2% for the MRSA group and 55.6% for the MRB group (p = 0.005). Among the other risk factors for treatment failure, the presence of inflammatory arthritis presented a failure rate of 45.1 (p < 0.05). Conclusion DAIR showed a good success rate in cases of early acute infection by multidrug-sensitive bacteria. In the presence of infection by multidrug-resistant bacteria or association with rheumatic diseases the treatment failure rate was higher and other surgical options should be considered in this specific population. The MRSA group showed intermediate results between MSB and MRB and should be carefully evaluated.
- Outcomes After Isolated Acute Anterior Cruciate Ligament Reconstruction Are Inferior in Patients With an Associated Anterolateral Ligament Injury(2020) SOBRADO, Marcel Faraco; GIGLIO, Pedro Nogueira; BONADIO, Marcelo Batista; HELITO, Paulo Victor Partezani; GUIMARAES, Tales Mollica; PECORA, Jose Ricardo; GOBBI, Riccardo Gomes; HELITO, Camilo PartezaniBackground: Isolated reconstruction of the anterior cruciate ligament (ACL) does not reestablish the normal knee biomechanics in cases of associated injuries to the anterolateral structures. Studies evaluating the potential clinical effect of anterolateral ligament (ALL) injury on the treatment of ACL injuries are necessary to validate the findings of biomechanical studies. Purpose: To evaluate the clinical outcomes and failure rate of ACL reconstruction in patients with and without ALL injury diagnosed using magnetic resonance imaging. Study Design: Cohort study; Level of evidence, 2. Methods: A prospective cohort of patients with acute ACL injury was divided into 2 groups based on the presence (ALL group) or absence (no-ALL group) of ALL injury on preoperative magnetic resonance imaging scans. Both groups underwent anatomic reconstruction of the ACL with autologous hamstring tendon grafts. The Lysholm and subjective IKDC scores (International Knee Documentation Committee), KT-1000 arthrometer and pivot-shift test results, reconstruction failure rate, incidence of contralateral ACL injury, presence of associated meniscal injury, and presence of knee hyperextension were evaluated. Results: A total of 182 patients were evaluated. Postoperative mean +/- SD follow-up was 33.6 +/- 7.1 and 36.1 +/- 8.1 months for the ALL and no-ALL groups, respectively. No significant differences were found between the groups in terms of age, sex, knee hyperextension, duration of injury before reconstruction, follow-up time, or associated meniscal injuries. In the preoperative evaluation, the pivot-shift grade was similar, and the ALL group had worse KT-1000 arthrometer values (7.9 +/- 1.2 mm vs 7.2 +/- 1.1 mm; P < .001). In the postoperative evaluation, patients in the no-ALL group had a lower reconstruction failure rate (10.2% vs 1.4%; P = .029) and better clinical outcomes according to the IKDC subjective (85.5 +/- 10.7 vs 89.1 +/- 6.6; P = .035) and Lysholm scores (85.9 +/- 10.1 vs 92.0 +/- 6.3; P < .001). There was no postoperative difference in the KT-1000 or pivot-shift results. Conclusion: Combined ACL and ALL injuries were associated with significantly less favorable outcomes than were isolated ACL injuries at a minimum follow-up of 2 years after ACL reconstruction. Patients with concomitant ALL injury showed a higher rerupture rate and worse functional scores.
- Treatment of subchondral insufficiency fracture of the knee by subchondroplasty(2020) BONADIO, Marcelo Batista; GIGLIO, Pedro Nogueira; HELITO, Camilo Partezani; SILVA, Hugo Pereira da; GOBBI, Riccardo Gomes; CAMANHO, Gilberto Luis; DEMANGE, Marco KawamuraBackground: Subchondral insufficiency fracture greatly impacts the quality of life of patients, causes much pain, and has the potential to rapidly progress to degeneration of the knee. Application of a calcium phosphate bone graft to the subchondral insufficiency fracture area has emerged as a relevant therapeutic approach to improve symptoms and avoid the occurrence of bone collapse. The aim of the present study was to evaluate subchondroplasty of the knee regarding its applicability and results in terms of function improvement and prevention of evolution of joint degeneration. Methods: Eleven 40- to 75-year-old patients with pain of the knee for at least 6 months who were diagnosed with subchondral insufficiency fracture. The diagnosis was established based on clinical assessment and MRI. The typical abnormality observed on MRI was a high signal intensity bone marrow lesion adjacent to low signal intensity cortical thickening on T2-weighted. Patients with articular surface collapse or osteoarthrosis with a Kellgren-Lawrence grade higher than 3 were excluded. Patients were assessed based on a pain visual analogue scale (VAS) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) score. Results: The KOOS score for function increased from 43.0 (35.1-48.2) before surgery to 89.9 (89.3-94.0) [median (interquartile range), P=0.0033] after surgery, and the VAS score decreased from 9 [7-10] to 1 [0-3] [median (interquartile range), P=0.0032]. Conclusions: Subchondroplasty was shown to be safe, applicable, and efficacious for improvement of pain and the KOOS score for subchondral insufficiency fractures of the knee.