ISIS AKEMI KATAYAMA RANGEL
Projetos de Pesquisa
Unidades Organizacionais
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina
5 resultados
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conferenceObject Myocardial AT1 gene expression is increased in a model of left ventricular hypertrophy induced by high salt intake(2013) PEREIRA, Rafael Canavel; KATAYAMA, Isis Akemi; HEIMANN, Joel ClaudioObjective: To evaluate gene expression of the renin-angiotensin system components in a model of left ventricular hypertrophy induced by high salt intake demonstrated in a previous study. Methods: Wistar rats were fed normal (NS1.3% NaCl) or high (HS 8%) salt diet since weaning. From the 7th week of age, two HS subgroups received hydralazine or losartan (HZ 15 and LOS 20mg/kg/day). Angiotensinogen, renin, ACE, ACE2, AT1 and AT2 gene expression in left ventricle were measured. Data are reported as mean±SEM. Means in row with superscripts without a common letter differ, P<0.05. Conclusion: High salt intake increases AT1 gene expression, however it is prevented by losartan treatment.conferenceObject Lysine Specific Demethylase-1 Deficiency Accelerates the Development of Hypertension and Renal Damage During Long Term Sodium Intake(2019) KATAYAMA, Isis Akemi; CULLINANE, Danielle L.; WILLIAMS, Gordon H.; HEIMANN, Joel Claudio; POJOGA, Luminita H.conferenceObject Male Mice Heterozygous LSD1 Knockout Gene Prevented the Effect of High Sodium Intake on Renal Fibrosis and AT1 Conformational Status(2019) NASCIMENTO, Mariana Moura; KATAYAMA, Isis Akemi; POJOGA, Luminita H.; HEIMANN, Joel ClaudioconferenceObject Salt induced cardiac hypertrophy is blood pressure independent and prevented by Losartan and N-acetylcysteine(2013) KATAYAMA, Isis Akemi; PEREIRA, Rafael Canavel; SHIMIZU, Maria Heloisa Massola; HEIMANN, Joel ClaudioconferenceObject Mechanisms of myocardial alterations induced by chronic high-salt intake(2012) KATAYAMA, Isis Akemi; DOPONA, Ellen Priscila Brito; HEIMANN, Joel Claudio