LUIS DOS RAMOS MACHADO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Neurologia, Faculdade de Medicina - Docente
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina
14 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 14
- Arquivos de Neuro-Psiquiatria in the Brazilian Academy of Neurology: natural evolution(2015) MACHADO, Luis dos Ramos; LIVRAMENTO, Jose Antonio
- Arquivos de Neuro-Psiquiatria has new Editors(2017) MACHADO, Luis dos Ramos; LIVRAMENTO, Jose Antonio
conferenceObject Clinical Course of LETM Associated with Neuroschistosomiasis(2013) APOSTOLOS-PEREIRA, Samira; MARCHIORI, Paulo; MACHADO, Luis; LIVRAMENTO, Jose; GOMES, Helio; LUCATO, Leandro; CALLEGARO, Dagoberto- Arquivos de Neuro-Psiquiatria: 80 years(2023) MASSARO, Ayrton; TEIVE, Helio A. G.; LIVRAMENTO, Jose Antonio; MACHADO, Luis dos Ramos; CARAMELLI, Paulo
bookPart Meningites(2017) MACHADO, Luis dos Ramos; LIVRAMENTO, José Antonio; VIANNA, Liliana ScaffbookPart Liquido Cefalorraquidiano(2015) LIVRAMENTO, José Antonio; MACHADO, Luis dos Ramos; FRANçA NETO, Antonio SpinabookPart Meningites(2023) MACHADO, Luis dos Ramos; LIVRAMENTO, José Antonio; VIANNA, Liliana Scaff; OLIVEIRA, Vitor Falcão de; NUNES, Maria do PatrocínioTenóriobookPart Exames Complementares em Neurologia(2015) LIVRAMENTO, José Antonio; MACHADO, Luis dos Ramos; FRANçA NETO, Antonio Spina; ANGHINAH, Renato; BROTTO, Mario Wilson Iervolino- Oligoclonal Bands in Cerebrospinal Fluid of Black Patients with Multiple Sclerosis(2015) GAMA, Paulo Diniz da; MACHADO, Luis dos Ramos; LIVRAMENTO, Jose Antonio; GOMES, Helio Rodrigues; ADONI, Tarso; MORALES, Rogerio de Rizo; GAMA, Rodrigo Assad Diniz da; GAMA, Daniel Assad Diniz da; LANA-PEIXOTO, Marco Aurelio; FRAGOSO, Yara Dadalti; CALLEGARO, DagobertoGenetic susceptibility is a well-recognized factor in the onset of multiple sclerosis (MS). The objective of this study was to determine the frequency of oligoclonal bands (OCB) restricted to the cerebrospinal fluid, in an ethnically mixed group of MS patients in the city of Sao Paulo, Brazil. Techniques used to detect OCB consisted of isoelectric focusing followed by immunoblotting. OCB were found in 49 (54.4%) out of 90 patients with clinically definite MS; out of the 23 brown/black patients, 17 (73.9%) were OCB+; out of the 66 white patients, 32 (48.5%) were OCB+; and the only patient yellow was OCB+ (P = 0.05). Analysis of the IgG index was also consistent with the findings, but with lower statistical significance. The data presented in our study show that the ethnic differences in MS extend to the immune response.
- Spectrum of cognitive impairment in neurocysticercosis Differences according to disease phase(2012) RODRIGUES, C. L.; ANDRADE, D. C. de; LIVRAMENTO, J. A.; MACHADO, L. R.; ABRAHAM, R.; MASSAROPPE, L.; LUCATO, L. T.; CARAMELLI, P.Objectives: Cognitive decline related to neurocysticercosis (NC) remains poorly characterized and underdiagnosed. In a cross-sectional study with a prospective phase, we evaluated cognitive decline in patients with strictly calcified form (C-NC), the epidemiologically largest subgroup of NC, and investigated whether there is a spectrum of cognitive abnormalities in the disease. Methods: Forty treatment-naive patients with C-NC aged 37.6 +/- 11.3 years and fulfilling criteria for definitive C-NC were submitted to a comprehensive cognitive and functional evaluation and were compared with 40 patients with active NC (A-NC) and 40 healthy controls (HC) matched for age and education. Patients with dementia were reassessed after 24 months. Results: Patients with C-NC presented 9.4 +/- 3.1 altered test scores out of the 30 from the cognitive battery when compared to HC. No patient with C-NC had dementia and 10 patients (25%) presented cognitive impairment-no dementia (CIND). The A-NC group had 5 patients (12.5%) with dementia and 11 patients (27.5%) with CIND. On follow-up, 3 out of 5 patients with A-NC with dementia previously still presented cystic lesions with scolex on MRI and still had dementia. One patient died and the remaining patient no longer fulfilled criteria for either dementia or CIND, presenting exclusively calcified lesions on neuroimaging. Conclusions: Independently of its phase, NC leads to a spectrum of cognitive abnormalities, ranging from impairment in a single domain, to CIND and, occasionally, to dementia. These findings are more conspicuous during active vesicular phase and less prominent in calcified stages.