CARLOS EDUARDO NEGRAO
Projetos de Pesquisa
Unidades Organizacionais
EFB, EEFE - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
30 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 30
conferenceObject Discriminating sarcopenia in male patients with heart failure: the influence of body mass index(2018) SANTOS, M. R. Dos; FONSECA, G. W. P.; SOUZA, F. R.; CASTRO, V. M.; TAKAYAMA, L.; PEREIRA, R. M. R.; NEGRAO, C. E.; ALVES, M. J. N. N.conferenceObject Coronary inflammation by computed tomography pericoronary fat attenuation in young male anabolic androgenic steroid users(2022) SOUZA, F.; ROCHITTE, C. E.; SILVA, D. C.; GOMES, A. M. R.; SANTOS, M. R.; FONSECA, G. W. P.; BATTAGLIA, A. C. B. F.; CORREA, K. T. S.; YONAMINE, M.; PEREIRA, R. M. R.; NEGRAO, C. E.; ALVES, M. J. N. N.conferenceObject Effect of exercise training on HDL subclasses and cholesterol transfers to HDL in elderly individuals(2022) BRAGA, P. G. Senger; TAVONI, T. M.; BARONI, R. V.; ALDIN, M. N.; ALVES, M. J. N. N.; ROCHA, G. A.; BACHI, A. L. L.; NEGRAO, C. E.; VAISBERG, M. W.; FREITAS, F. R.; FIGUEIREDO NETO, A. M.; DAMASCENO, N. R. T.; MARANHAO, R. C.article 43 Citação(ões) na Scopus Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function(2011) BRUM, P. C.; BACURAU, A. V. N.; MEDEIROS, A.; FERREIRA, J. C. B.; VANZELLI, A. S.; NEGRAO, C. E.Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training.conferenceObject Hypocaloric diet and exercise training improve postexercise sympatho-vagal balance in patients with metabolic syndrome and obstructive sleep apnea(2014) CEPEDA, F. X.; TOSCHI-DIAS, E.; MAKI-NUNES, C.; RODRIGUES, S.; RONDON, M. U. P. B.; DRAGER, L. F.; ALVES, M. J. N. N.; LORENZI-FILHO, G.; NEGRAO, C. E.; TROMBETTA, I. C.conferenceObject Dynamic cerebral autoregulation changes during sub-maximal handgrip maneuver(2013) NOGUEIRA, R. C.; BOR-SENG-SHU, E.; SANTOS, M. R.; NEGRAO, C. E.; TEIXEIRA, M. J.; PANERAI, R.conferenceObject Effect of exercise stress test on platelet function in patients with recent acute myocardial infarction(2019) DALCOQUIO, T.; SANTOS, M. A.; ALVES, L. S.; ARANTES, F. B. B.; FERREIRA-SANTOS, L.; RONDON, M. U. P. B.; ALVES, M. J. N. N.; FURTADO, R. H. M.; FERRARI, A. G.; GENESTRETI, P. R.; REALI, F. R.; RODRIGUEZ, M. R. S.; FRANCI, A.; NEGRAO, C. E.; NICOLAU, J. C.conferenceObject Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure(2019) SANTOS, M. R. Dos; FONSECA, G. W. P.; SHERVENINAS, L.; SOUZA, F. R.; BATTAGLIA FILHO, A. C.; PEREIRA, R. M. R.; NEGRAO, C. E.; ALVES, M. J. N. N.; BARRETTO, A. C. P.conferenceObject Exercise-induced muscle vasodilatation and genetic polymorphisms of alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin receptor B2 in individuals without overt heart disease(2013) NUNES, R. A. Belo; BARROSO, L. P.; RONDON, M. U.; NEGRAO, C. E.; PEREIRA, A. C.; MANSUR, A. J.conferenceObject Mechanisms of blunted muscle vasodilation during peripheral chemoreceptor stimulation in heart failure patients(2012) ALVES, M. J. N. Nunes; SANTOS, M. R. Dos; NOBRE, T. S.; MARTINEZ, D. G.; BARRETTO, A. C. P.; BRUM, P. C.; RONDON, M. U. P. B.; MIDDLEKAUFF, H. R.; NEGRAO, C. E.Purpose: We recently described that systemic hypoxia provokes vasoconstriction in HF patients, Which might due to augmented sympathetic nerve activity to muscle (MSNA), in this study, we tested the hypothesis that either the exaggerated MSNA and/or blunted endothelial dysfunction mediate the blunted vasodilation during hypoxia in HF patients. Methods: Twenty seven HF patients and 23 age-matched healthy controls were studied. MSNA was assessed by microneurography and forearm blood flow (FBF) by venous occlusion plethysmography. Peripheral chemoreflex control was evaluated through the inhaling of a hypoxic gas mixture (10% O2 and 90% N2). Results: MSNA (P=0.001) were greater and basal FBF levels (P=0.003) were lower in HF patients versus controls. During hypoxia, MSNA responses were greater in HF patients (P=0.02), and forearm vasodilatation was blunted in HF compared to controls (P=0.002). In the presence of phentolamine, hypoxia significantly increased FBF responses in both groups, but the increase was lower in HF patients versus controls (P=0.003). Phentolamine + L-NMMA infusion during hypoxia did not change FBF responses in HF, but markedly blunted the vasodilatation in controls (P=0.96). FBF responses to hypoxia in the presence of vitamin C, an antioxidant that promotes NO availability, were unch anged when compared with saline infusion, and remained lower in HF patients versus controls. Conclusions: Muscle vasoconstriction in response to hypoxia in HF patients is due to exaggerated reflex sympathetic nerve activation and blunted endothelial function (NO activity). We were unable to identify a role for oxidative stress in these studies.
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