VALERIA DE FALCO CAPARBO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject Bone Metabolism Impairment in Heart Transplant: Results from a Prospective Cohort Study(2019) SEGURO, Luis; PEREIRA, Rosa; SEGURO, Luciana; CAPARBO, Valeria; AVILA, Monica; MANGINI, Sandrigo; CAMPOS, Iascara; GAIOTTO, Fabio; MARCONDES-BRAGA, Fabiana; BACAL, Fernando- Bone microarchitecture as measured using HR-pQCT of male Fabry disease patients and GLA gene GVUS subjects(2019) ROSA NETO, Nilton S.; BENTO, Judith C. B.; TAKAYAMA, Liliam; CAPARBO, Valeria F.; PEREIRA, Rosa Maria R.
- Assessment of bone mineral density and FRAX tool analysis in a cohort of male Fabry disease patients and GLA gene GVUS subjects(2019) ROSA NETO, Nilton S.; BENTO, Judith C. B.; TAKAYAMA, Liliam; CAPARBO, Valeria F.; PEREIRA, Rosa Maria R.
- Risk factors for bone loss in juvenile-onset systemic lupus erythematosus: a prospective study(2019) SOUSA, L. F. A. de; PAUPITZ, J. A.; AIKAWA, N. E.; TAKAYAMA, L.; CAPARBO, V. F.; PEREIRA, R. M. R.Objective Juvenile-onset systemic lupus erythematosus (JoSLE) is associated with low bone mass for age and fractures; nevertheless, risk factors for bone impairment are poorly understood. The aim of this study was to evaluate risk factors for bone mass loss in JoSLE patients. Methods Forty-nine female JoSLE patients were evaluated at baseline and after a 3.5-year follow-up regarding clinical, laboratory (including bone turnover markers), areal bone mineral density (aBMD) and bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT). Based on the difference between final and baseline aBMD value, the patients were divided into three groups: aBMD gain (BG), aBMD loss (BL) and aBMD no change (NC). Results The mean patient age was 18.7 +/- 3.3 years. Sixty-one percent of patients presented with aBMD gain, 18.4% aBMD loss, and 20.4% remained stable during this follow-up period. Comparing the BL with the BG group, there was a higher frequency of alcohol consumption (p = 0.009), a higher frequency of inadequate calcium intake (p = 0.047) and lower levels of baseline procollagen type 1 amino-terminal propeptide (P1NP) (p = 0.036) in the BL group. Moreover, worsening of HR-pQCT parameters trabecular volumetric density (p = 0.003) and cortical thickness (p = 0.009) was observed in the BL group. In addition, a higher frequency of renal activity was observed comparing the BL + NC with the BG group (p = 0.036). Conclusions This is the first longitudinal study that has analyzed the risk factors of bone loss in JoSLE patients. The authors emphasize the importance of evaluating lifestyle habits and renal disease activity in these young women. Furthermore, this study suggests that trabecular and cortical compartments deteriorated, and low levels of P1NP may be a predictor of bone impairment in JoSLE.
conferenceObject EXERCISE AS A TREATMENT TO ATTENUATE BONE LOSS IN WOMEN AFTER ROUX-EN-Y GASTRIC BY PASS : A RANDOMIZED CONTROLLED TRIAL(2019) MURAI, I. H.; ROSCHEL, H.; DANTAS, W. S.; GIL, S.; MEREGE-FILHO, C. A.; CAPARBO, V.; TAKAYAMA, L.; SA-PINTO, A. L.; CLEVA, R.; SANTO, M. A.; KIRWAN, J.; PEREIRA, R. M.; GUALANO, B.- Dual-energy X-ray absorptiometry body composition assessment in male Fabry disease patients and GLA gene GVUS subjects(2019) ROSA NETO, Nilton S.; BENTO, Judith C. B.; TAKAYAMA, Liliam; CAPARBO, Valeria F.; PEREIRA, Rosa Maria R.
conferenceObject Elucidating the crosstalk among lncRNAs, microRNAs and mRNAs in the bone metabolism related genes associated with Coronary Vascular Calcification in elderly women cohort of the Sao Paulo Aging and Health Study(2019) WICIK, Zofia; NETO, Levi H. Jales; TAKAYAMA, Liliam; CAPARBO, Valeria F.; FERNANDES, Georgea H.; PEREIRA, Rosa M. R.; LOPES, Neuza; GUZMAN, Luis F. E.; PEREIRA, Alexandre C.- Inflammation in Fabry disease: Correlation with Mainz Severity Score Index (MSSI)(2019) ROSA NETO, Nilton S.; BENTO, Judith C. B.; CAPARBO, Valeria F.; PEREIRA, Rosa Maria R.
conferenceObject Cortical Bone Erosion in the 2nd Metacarpal Bone Head: Association with Its Bone Mineral Density by HR-pQCT in Rheumatoid Arthritis Patients(2019) FIGUEIREDO, Camille; PEREZ, Mariana; RIBEIRO, Ana Cristina de Medeiros; CAPARBO, Valeria; PEREIRA, Rosa- Association of Appendicular Lean Mass, and Subcutaneous and Visceral Adipose Tissue With Mortality in Older Brazilians: The Sao Paulo Ageing & Health Study(2019) SANTANA, Felipe M. de; DOMICIANO, Diogo S.; GONCALVES, Michel A.; MACHADO, Luana G.; FIGUEIREDO, Camille P.; LOPES, Jaqueline B.; CAPARBO, Valeria F.; TAKAYAMA, Lilliam; MENEZES, Paulo R.; PEREIRA, Rosa M. R.Body composition changes as a result of ageing may impact the survival of older adults. However, its influence on mortality risk is uncertain. Currently, the best method for body composition analysis in clinical practice is DXA. Nonetheless, the few studies on body composition by DXA and mortality risk in the elderly have some limitations. We investigated the association between body composition by DXA and mortality in a cohort of elderly subjects. Eight hundred thirty-nine community-dwelling subjects (516 women, 323 men) >= 65 years of age were assessed by a questionnaire, clinical data, laboratory exams, and body composition by DXA at baseline. Total fat and its components (eg, visceral adipose tissue [VAT]) were estimated. Appendicular lean mass (ALM) adjusted for fat and ALM divided by height(2) was used to ascertain the presence of low muscle mass (LMM). Mortality was recorded during follow-up. Multivariate logistic regression was used to compute ORs for all-cause and cardiovascular mortality. Over a mean follow-up of 4.06 +/- 1.07 years, there were 132 (15.7%) deaths. In men, after adjustment for relevant variables, the presence of LMM (OR, 11.36, 95% CI, 2.21 to 58.37, P = 0.004) and VAT (OR, 1.99, 95% CI, 1.38 to 2.87, P < 0.001, for each 100-g increase) significantly increased all-cause mortality risk, whereas total fat, measured by the fat mass index, was associated with decreased mortality risk (OR, 0.48, 95% CI, 0.33 to 0.71, P < 0.001). Similar results were observed for cardiovascular mortality. In women, only LMM was a predictor of all-cause (OR, 62.88, 95% CI, 22.59 to 175.0, P < 0.001) and cardiovascular death (OR, 74.54, 95% CI, 9.72 to 571.46, P < 0.001). LMM ascertained by ALM adjusted for fat and fat mass by itself are associated with all-cause and cardiovascular mortality risk in the elderly. Visceral and subcutaneous fat have opposite roles on mortality risk in elderly men. Thus, DXA is a promising tool to estimate risk of mortality in the elderly. (c) 2019 American Society for Bone and Mineral Research.