DEWTON DE MORAES VASCONCELOS
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Diagnosis, treatment and maxillofacial rehabilitation in rhinocerebral mucormycosis patient: A case report and review of the literature(2022) SANTOS, Rennan Luiz Oliveira Dos; ELCHIN, Cintia Baena; GUIGUER-PINTO, Vitor Ancheschi; VASCONCELOS, Dewton de Moraes; FERREIRA, Mauricio Domingues; DIAS, Reinaldo Brito; SUGAYA, Norberto Nobuo; PAULA, Claudete Rodrigues; COTO, Neide PenaMucormycosis is an aggressive, rare and opportunistic infectious disease, with a high mortality rate. Etiologic agents are filamentous fungi, and infection among humans normally occurs through spore inhalation. A 61-year-old male individual, presenting left eye amaurosis, dark epistaxis, hyperalgesia and malodor underwent clinical examination, which detected ulcerative lesion and wide bone exposure in the hard palate and alveo-lar ridge. Direct microbiological examination, microbiological culture and lesion biopsy were performed. Non-septate smooth fungal hyphae forming right angles with each other were observed through the direct microbiological examination. Microbiological culture revealed fast-growing fungal colonies with cottony tex-ture, identified as Rhizopus sp. Histopathological examination exhibited necrosis areas, intense mononuclear inflammatory infiltrate and bulky hyphae, thus concluding the mucormycosis diagnosis. Amphotericin B antifungal therapy and surgical intervention were adopted as treatment. The patient was then rehabilitated with maxillofacial prosthesis, subsequently to the healing of the surgical wound.
- A rare association between factor H deficiency and lupus: Case report and experimental treatment with curcumin(2022) MACEDO, Ana Catarina Lunz; LORES, Lazara Elena Santisteban; ALBUQUERQUE, Jose Antonio Tavares; DUARTE, Nilo Jose Coelho; ROMANO, Paschoalina; EBNER, Persio Almeida Rezende; REZENDE, Vinicius Marcondes; SILVA, Clovis A. A.; ANDRADE, Luis Eduardo Coelho; VASCONCELOS, Dewton Moraes; ISAAC, LourdesFactor H (FH) is one of the most important regulatory proteins of the alternative pathway of the complement system. FH deficiency is a rare condition that causes unregulated C3 consumption, leading to an increased susceptibility to infections and glomerulopathies. Our previous studies have demonstrated a FH deficient patient carrying a c.452G > A, p.R127H FH mutation which leads to a misfolded protein and its retention in the endoplasmic reticulum. In his cultured fibroblasts, FH-delayed secretion was partially rescued when treated with curcumin, and once secreted, exhibited normal regulatory function. Here, we report a childhood-onset systemic lupus erythematosus (cSLE) in this FH deficient patient and the results of experimental treatment with curcumin aiming to rescue FH secretion and regulatory activity.
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and esophageal rupture by candida infection: A case report and review(2022) DOMINGUES-FERREIRA, Mauricio; VASCONCELOS, Dewton de Moraes; BEZERRA, Thiago de Almeida; BERTOLINI, Dalton Luis; BARROS, Noac Chuffi; AULER, Marcos ErenoWe probably describe the first report of esophageal rupture in a patient with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED, OMIM # 240300), who had candida esophagitis as the main feature for decades. Strong evidence shows that this rupture may have been caused directly and indirectly by chronic candidiasis. In this way, we demonstrate how severe and harmful the persistent esophageal candidiasis can cause in the esophagus, especially in immunodeficient patients.
- Clearance of Persistent SARS-CoV-2 RNA Detection in a NF kappa B-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report(2022) SABINO, Janine S.; AMORIM, Mariene R.; SOUZA, William M. de; MAREGA, Lia F.; MOFATTO, Luciana S.; TOLEDO-TEIXEIRA, Daniel A.; FORATO, Julia; STABELI, Rodrigo G.; COSTA, Maria Laura; SPILKI, Fernando R.; SABINO, Ester C.; FARIA, Nuno R.; BENITES, Bruno D.; ADDAS-CARVALHO, Marcelo; STUCCHI, Raquel S. B.; VASCONCELOS, Dewton M.; WEAVER, Scott C.; GRANJA, Fabiana; PROENCA-MODENA, Jose Luiz; VILELA, Maria Marluce dos S.Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NF kappa B-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.
- Evaluation of IFN-gamma secretion after stimulation with C. neoformans and C. gattii antigens in individuals with frequent exposure to the fungus(2022) MACIEL, Isabel Feitosa; FREITAS-XAVIER, Roseli Santos de; VICENTINI, Adriana Pardini; APOLIANO, Carlos Fernando; FERNANDES, Juliana Ruiz; DIAS, Alana dos Santos; GIMENES, Viviane Favero Mazo; BENARD, Gil; VASCONCELOS, Dewton MoraesIn this study we produced antigenic extracts from prototypical strains of C. neoformans (VNI-VNIV) and C. gattii (VGI-VGIV) and tested IFN-gamma secretion by Elispot. Antigens from the eight Cryptococcus molecular types (VNI -VNIV and VGI - VGIV) were obtained after capsule reduction. IFN-gamma secretion by Elispot method were stimulated with C. neoformans and C. gattii antigens. Peripheral blood mononuclear cells of fourteen healthy control subjects, being: five ecotourists, two mycologists, three poultry keepers, and four individuals without reports of exposure to the fungus. We observed a significant increase in IFN-gamma secretion in the group of ecotourists, mycologists and bird keepers in relation to the group of individuals without reports of occupational exposures to these agents. Our results suggest the significant increase in IFN-gamma secretion may be related to the continuous exposure of these groups of individuals to the fungus, as well as to the specific antigen memory immune response developed during exposure to Cryptococcus.