RICARDO WAKSMAN
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Comparative Effectiveness of Intravesical BCG-Tice and BCG-Moreau in Patients With Non-muscle-invasive Bladder Cancer(2020) D'ANDREA, David; SORIA, Francesco; ABUFARAJ, Mohammad; PONES, Mario; GONTERO, Paolo; MACHADO, Andre T.; WAKSMAN, Ricardo; ENIKEEV, Dmitry V.; GLYBOCHKO, Petr V.; ADONIAS, Sanarelly Pires; NAHAS, William Carlos; SHARIAT, Shahrokh F.; CHADE, Daher C.We compared the oncologic outcomes of patients treated with bacillus Calmette-Guerin (BCG)-Tice versus BCG-Moreau for non-muscle-invasive bladder cancer using inverse-probability survival analyses and found no significant difference in recurrence- and progression-free survival between strains. However, the use of maintenance cycles was significantly associated with improved recurrence- and progression-free survival. Prospective designed trials are required to confirm these findings in light of the BCG shortage. Background: The purpose of this study was to compare the efficacy of 2 bacillus Calmette-Guerin (BCG) strains, BCG-Tice and BCG-Moreau, in the treatment of non-muscle-invasive bladder cancer (NMIBC). Materials and Methods: We retrospectively reviewed clinical data from patients treated with BCG for NMIBC at 3 academic centers. Inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier curves and Cox proportional hazards regression analyses were used to compare recurrence-free (RFS) and progression-free survival (PFS) of patients in the 2 treatment groups. In addition, we performed exploratory analyses of treatment effect according to the receipt of adequate BCG treatment, high-risk disease, age, gender, smoking status, pathologic stage, and pathologic grade. Results: A total of 321 (48.6%) patients were treated with BCG-Tice and 339 (51.4%) with BCG-Moreau. IPTW-adjusted Cox proportional hazard regression analysis did not show a difference in RFS (hazard ratio, 0.88; 95% confidence interval, 0.56-1.38; P = .58) or PFS (hazard ratio, 0.55; 95% confidence interval, 0.25-1.21, P = .14) between BCG-Tice and BCG-Moreau. On subgroup analyses, we could not identify an association of BCG strain with outcomes. Conclusions: There was no difference in RFS and PFS between BCG-Tice and BCG-Moreau strains in the adjuvant treatment of NMIBC. However, we confirmed the importance of maintenance therapy for achieving a sustainable response in patients with intermediate- and high-risk NMIBC.
- Effectiveness of the Moreau strain of Bacillus Calmette-Guerin (BCG) for nonmuscle invasive bladder cancer.(2017) CHADE, Daher Cezar; MACHADO, Andre; WAKSMAN, Ricardo; GARCIA, Guilherme; ESTEVES, Paulo; ADONIAS, Sanarelly; BOTELHO, Luis; CORDEIRO, Mauricio; MURTA, Claudio; RIBEIRO-FILHO, Leopoldo; SARKIS, Alvaro; BASTOS, Diogo Assed; DZIK, Carlos; SROUGI, Miguel; NAHAS, William Carlos
conferenceObject BLOOD-BASED BIOMARKERS AS PREDICTORS OF ONCOLOGIC OUTCOMES FOR NON-MUSCLE-INVASIVE UROTHELIAL BLADDER CARCINOMA(2017) CHADE, Daher; MACHADO, Andre; WAKSMAN, Ricardo; GARCIA, Guilherme; ESTEVES, Paulo; ADONIAS, Sanarelly; AREAS, Flavio; BOTELHO, Luis; CORDEIRO, Mauricio; MURTA, Claudio; RIBEIRO-FILHO, Leopoldo; SARKIS, Alvaro; SHARIAT, Shahrokh; BASTOS, Diogo; DZIK, Carlos; SROUGI, Miguel; NAHAS, William