JOAO PAULO MANCUSI DE CARVALHO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject RETROSPECTIVE ANALYSIS OF RADICAL HYSTERECTOMY IN A SINGLE BRAZILIAN CANCER CENTER(2016) CARVALHO, J. P. Mancusi de; GENTA, M. L. Nogueira Dias; SADALLA, J. C.; NOBREGA, F. de Souza; ORTOLAN, N. Macerox; CARVALHO, J. PaulaconferenceObject In Bag Morcellation: details and logistics of the technique(2016) FERNANDES, R.; ARAUJO, M.; SILVA, A. Silva e; CARVALHO, P. Mancusi de; ANTON, C.; GENTA, M. L. Nogueira Dias; RIBEIRO JR., A. Dias; SAMPAIO, D.; MIGLINO, G.; SADALLA, J. C.; CARVALHO, J. Paula- L1 cell adhesion molecule (L1CAM) in stage IB cervical cancer: distinct expression in squamous cell carcinomas and adenocarcinomas(2020) CARVALHO, Joao Paulo Mancusi de; SALIM, Rafael C.; CARVALHO, Filomena Marino; GENTA, Maria Luiza Nogueira Dias; BARACAT, Edmund Chada; CARVALHO, Jesus PaulaAims L1 cell adhesion molecule (L1CAM) has been shown to be correlated with tumour progression, attributed to its possible association with epithelial-mesenchymal transition (EMT), characterised by the expression of vimentin and loss of e-cadherin. Herein, we investigate the associations between L1CAM and clinicopathological parameters, as well as the expression of vimentin and e-cadherin, in carcinomas restricted to the cervix. Methods The study was retrospective observational and included 45 squamous cell carcinomas (63.4%) and 26 adenocarcinomas (36.6%) submitted to primary surgical treatment. Patient age, FIGO (International Federation of Gynecology and Obstetrics) stage, tumour size and follow-up were obtained from the medical records. All the slides were revised to evaluate histological differentiation, lymphovascular space invasion, depth of infiltration, disease-free cervical wall thickness, pattern of invasion front, Silva pattern (for adenocarcinomas) and the percentage of tumour-infiltrating lymphocytes. Tissue microarrays were constructed for immunohistochemical staining for L1CAM, e-cadherin and vimentin. Results Adenocarcinomas were associated with lower disease-free and overall survival. L1CAM and vimentin expressions were more frequent among adenocarcinomas, although loss of e-cadherin expression was more common among squamous carcinomas. L1CAM expression was associated with larger tumours, vimentin expression and lower disease-free survival. No association was observed between the expression of either L1CAM or vimentin and loss of e-cadherin. High levels of tumour-infiltrating lymphocytes were more frequent in squamous cell carcinoma, high-grade tumours, destructive pattern at front of invasion and loss of e-cadherin expression. Conclusions Our results confirm the prognostic role of L1CAM in cervical carcinomas, but suggest a role for mechanisms other than EMT.
conferenceObject VAGINAL-ASSISTED LAPAROSCOPIC RADICAL HYSTERECTOMY (VALRH): INITIAL EXPERIENCE OF A GYNECOLOGICAL CANCER CENTER IN BRAZIL(2013) FAVERO, G.; SILVA, A. Silva e; ANTON, C.; RIBEIRO, A.; ARAUJO, M. Pereira; SADALLA, J.; MIGLINO, G.; BARACAT, E.; CARVALHO, J.- BORDERLINE OVARIAN TUMORS-10 YEARS SINGLE CENTER EXPERIENCE(2019) FERNANDES, R.; ANTON, C.; SILVA, A. Silva e; CARVALHO, J. P. Mancusi; ARAUJO, M.; GENTA, M. L. Dias; SAMPAIO, D.; MIGLINO, G.; DIAS JR., A.; SADALLA, J. C.; CARVALHO, J. Paula
conferenceObject BORDERLINE OVARIAN CANCER: 6 YEAR EXPERIENCE FROM A SINGLE INSTITUTE(2015) FERNANDES, R.; ANTON, C.; NOBREGA, F. S.; FARIA, M. B. S.; SILVA, A. Silva E; CARVALHO, J. P.conferenceObject INFLUENCE OF BODY MASS INDEX ON CLINICOPATHOLOGICAL PRESENTATION OF ENDOMETRIAL CARCINOMAS(2013) CARVALHO, J. P.; ANTON, C.; ARAUJO, M. P.; CARVALHO, F. M.conferenceObject CLINICOPATHOLOGICAL FEATURES OF ENDOMETRIAL CARCINOMA IN YOUNG AND OLD WOMEN(2013) ANTON, C.; CARVALHO, F. M.; CARVALHO, J. P. M.; FAVERO, G. M.; CARVALHO, J. P.conferenceObject LYMPHOVASCULAR SPACE INVASION IS HIGHLY ASSOCIATED WITH LYMPH NODE METASTASIS IN ENDOMETRIAL CANCER(2013) CARVALHO, F. M.; ANTON, C.; SADALLA, J. C.; AGUIAR, F. N.; CARVALHO, J. P.conferenceObject Human papillomavirus 16 is an independent predictor of better survival among patients with early cervical cancer(2016) GENTA, M. L. N. D.; LEVI, J. E.; MARTINS, T. R.; SADALLA, J. C.; LOPEZ, R. V. M.; CARVALHO, J. P. M.; CARVALHO, J. P.