MARIANA MOURA NASCIMENTO

(Fonte: Lattes)
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Lattes
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/12 - Laboratório de Pesquisa Básica em Doenças Renais, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 5 de 5
  • conferenceObject
    A SINGLE DOSE OF LITHIUM PROTECTS AGAINST RENAL INJURY FOLLOWING BILATERAL URETERAL OBSTRUCTION
    (2022) SHIMIZU, Maria Heloisa Massola; VOLPINI, Rildo Aparecido; BRAGANCA, Ana Carolina de; NASCIMENTO, Mariana Moura; BERNARDO, Desiree; CANALE, Daniele; SEGURO, Antonio Carlos
  • conferenceObject
    OBESITY ASSOCIATED WITH VITAMIN D DEFICIENCY IMPAIRS RENAL FUNCTION, HAEMODYNAMICS, METABOLIC PARAMETERS AND AGGRAVATES THE RENAL MORPHOLOGICAL DAMAGE IN RATS SUBMITTED TO ISCHAEMIA-REPERFUSION INJURY
    (2022) BERNARDO, Desiree; BRAGANCA, Ana Carolina de; SHIMIZU, Maria Heloisa Massola; SEGURO, Antonio Carlos; NASCIMENTO, Mariana Moura; CANALE, Daniele; VOLPINI, Rildo Aparecido
  • conferenceObject
    TREATMENT WITH NEBIVOLOL AMELIORATES RENOVASCULAR ALTERATIONS AND OXIDATIVE STRESS IN TENOFOVIR-INDUCED NEPHROTOXICITY IN RATS
    (2022) NASCIMENTO, Mariana Moura; BERNARDO, Desiree; BRAGANCA, Ana Carolina de; SHIMIZU, Maria Heloisa Massola; SEGURO, Antonio Carlos; VOLPINI, Rildo Aparecido; CANALE, Daniele
  • conferenceObject
    Male Mice Heterozygous LSD1 Knockout Gene Prevented the Effect of High Sodium Intake on Renal Fibrosis and AT1 Conformational Status
    (2019) NASCIMENTO, Mariana Moura; KATAYAMA, Isis Akemi; POJOGA, Luminita H.; HEIMANN, Joel Claudio
  • article 1 Citação(ões) na Scopus
    Administration of a single dose of lithium ameliorates rhabdomyolysis-associated acute kidney injury in rats
    (2023) SHIMIZU, Maria Heloisa Massola; VOLPINI, Rildo Aparecido; BRAGANCA, Ana Carolina de; NASCIMENTO, Mariana Moura; BERNARDO, Desiree Rita Denelle; SEGURO, Antonio Carlos; CANALE, Daniele
    Rhabdomyolysis is characterized by muscle damage and leads to acute kidney injury (AKI). Clinical and experimental studies suggest that glycogen synthase kinase 3 beta (GSK3 beta) inhibition protects against AKI basically through its critical role in tubular epithelial cell apoptosis, inflammation and fibrosis. Treatment with a single dose of lithium, an inhibitor of GSK3 beta, accelerated recovery of renal function in cisplatin and ischemic/reperfusion-induced AKI models. We aimed to evaluate the efficacy of a single dose of lithium in the treatment of rhabdomyolysis-induced AKI. Male Wistar rats were allocated to four groups: Sham, received saline 0.9% intraperitoneally (IP); lithium (Li), received a single IP injection of lithium chloride (LiCl) 80 mg/kg body weight (BW); glycerol (Gly), received a single dose of glycerol 50% 5 mL/kg BW intramuscular (IM); glycerol plus lithium (Gly+Li), received a single dose of glycerol 50% IM plus LiCl IP injected 2 hours after glycerol administration. After 24 hours, we performed inulin clearance experiments and collected blood / kidney / muscle samples. Gly rats exhibited renal function impairment accompanied by kidney injury, inflammation and alterations in signaling pathways for apoptosis and redox state balance. Gly+Li rats showed a remarkable improvement in renal function as well as kidney injury score, diminished CPK levels and an overstated decrease of renal and muscle GSK3 beta protein expression. Furthermore, administration of lithium lowered the amount of macrophage infiltrate, reduced NF kappa B and caspase renal protein expression and increased the antioxidant component MnSOD. Lithium treatment attenuated renal dysfunction in rhabdomyolysis-associated AKI by improving inulin clearance and reducing CPK levels, inflammation, apoptosis and oxidative stress. These therapeutic effects were due to the inhibition of GSK3 beta and possibly associated with a decrease in muscle injury.