EDUARDO LUIZ RACHID CANCADO

(Fonte: Lattes)
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Departamento de Gastroenterologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
P ICHC, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina

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Revista / Livro: Frontiers in Immunology ×

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Agora exibindo 1 - 3 de 3
  • article 11 Citação(ões) na Scopus
    The importance of autoantibody detection in autoimmune hepatitis
    (2015) CANCADO, Eduardo Luiz Rachid; ABRANTES-LEMOS, Clarice Pires; TERRABUIO, Debora Raquel B.
  • article 16 Citação(ões) na Scopus
    The importance of autoantibody detection in primary biliary cirrhosis
    (2015) CANCADO, Eduardo Luiz Rachid; HARRIZ, Michelle
  • article 1 Citação(ões) na Scopus
    HLA-related genetic susceptibility in autoimmune hepatitis according to autoantibody profile
    (2022) CANCADO, Eduardo Luiz Rachid; GOLDBAUM-CRESCENTE, Juliana; TERRABUIO, Debora Raquel B.
    Although the prevalence of autoimmune hepatitis in first-degree relatives is small, the relationship between genetic markers, especially human leucocyte antigens (HLA), and susceptibility to this disease, has been studied for over three decades. The genetic susceptibility to AIH is believed to be different in the two subtypes of the disease, AIH type 1 and AIH type 2. Type 1 AIH has anti-smooth muscle and anti-nuclear antibodies as its main markers, while those of type 2 AIH are the anti-liver/kidney microsome type 1 and anti-liver cytosol type 1 antibodies. The anti-soluble liver antigen/liver-pancreas antibodies, which, in addition to being present in both subtypes, mark an important number of patients without serological markers. Therefore, a third type of disease is questionable. The vast majority of immunogenetic studies compare the differences between the two main types and make no difference between which antibodies are present to define the subtype. This review seeks to analyze what was most important published in the AIH in this context, trying to relate the HLA alleles according to the AIH marker autoantibodies.