MARCOS NAOYUKI SAMANO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
LIM/61 - Laboratório de Pesquisa em Cirurgia Torácica, Hospital das Clínicas, Faculdade de Medicina
LIM/61 - Laboratório de Pesquisa em Cirurgia Torácica, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject Non Concordance Between Sputum and Pulmonary Explant Fragments Culture in Patients with Cystic Fibrosis After Lung Transplantation(2018) ATHANAZIO, R. A.; RACHED, S. Z.; STELMACH, R.; CUKIER, A.; CARVALHO-PINTO, R. M.; COSTA, A. N.; FERNANDES, F. L.; SAMANO, M. N.; TEIXEIRA, R. H.; CAMPOS, S. V.conferenceObject Long-Term Follow-Up of Non CF Bronchiectasis Patients After Lung Transplantation in a Single Brazilian Center(2018) SERRA, J. P.; JESUS, R. M. De; ATHANAZIO, R. A.; RACHED, S. Z.; CAMPOS, S. V.; COSTA, A. N.; AFONSO, J. E.; CARRARO, R. M.; TEIXEIRA, R. D.; FERNANDES, L. M.; ABDALLA, L.; SAMANO, M. N.- Lung transplantation with extracorporeal membrane oxygenation as intraoperative support(2018) SCHETTINI-SOARES, Mariana; LEITE, Pedro Henrique Cunha; HAJJAR, Ludhmila Abrahao; COSTA, Andre Nathan; PEGO-FERNANDES, Paulo Manuel; SAMANO, Marcos Naoyuki
conferenceObject Sternal Closure by Rigid Plate Fixation versus Traditional Technique After Clamshell Incision for Bilateral Lung Transplantation(2018) SAMANO, M. N.; COSTA, H. F.; FERNANDES, L. M.; ABDALLA, L.; GOMES JR., O.; MONDADORI, D. C.; CAMPOS, S. V.; CARRARO, R. M.; PEGO-FERNANDES, P. M.- Weight Gain and Acute Rejection in Patients Submitted to Pulmonary Transplantation: A Retrospective Cohort of 10 Years(2018) ARAUJO, I. Carvalho; VIEIRA, L. Proenca; ALVES, A. C. di Creddo; SAMANO, M. Naoyuki; TEIXEIRA, R. H. de Oliveira BragaObjective. Acute rejection is one of the most common complications after pulmonary transplantation. The aim of this work was to verify the association of nutritional status and weight gain with acute rejection in the recipient during the 1st year after pulmonary transplantation. Methods. Retrospective cohort study with patients submitted to pulmonary transplantation at a pulmonary transplantation center in the state of Sao Paulo. Data on sex, age, underlying disease, type of transplantation, and presence, degree, and frequency of rejection according to the transbronchial biopsy results were collected, along with body mass index (BMI) and weight variation over the course of 1 year. The difference between groups was analyzed by means of Student t test and the association by means of chi-square test. Significance was considered with P < .05. Results. A total of 117 patients were included, of which 71 (60.7%) were male. The average age was 39.8 +/- 15.5 years. There were 77.8% with acute rejection in the 1st year after transplantation. The nutritional status of eutrophy prevailed according to BMI in both adolescents and adults, with no association with acute rejection (P = .80), and there was a greater weight gain among the individuals who showed rejection, with an increase of 7.58 kg (95% confidence interval [CI] 6.35-8.81) compared with those who did not present rejection, whose average weight gain was 4.12 kg (95% CI 1.28-6.95; P = .01). Conclusions. Nutritional status was not associated with acute cell rejection in the 1st year after transplantation, although weight gain was greater in those who had rejection.
- Effect of hypertonic saline in the pretreatment of lung donors with hemorrhagic shock(2018) NEPOMUCENO, Natalia Aparecida; OLIVEIRA-BRAGA, Karina Andrighetti de; RUIZ, Liliane Moreira; CORREIA, Aristides Tadeu; PATO, Eduardo Zinoni Silva; SILVA, Luiz Fernando da; PEGO-FERNANDES, Paulo Manuel; SAMANO, Marcos NaoyukiBackground: Hemorrhagic shockeinduced lung edema and inflammation are two of the main reasons for the rejection of lungs donated for transplantation. Hypertonic saline (HS) induces intravascular volume expansion and has considerable immunomodulating effects that might minimize edema. Our hypothesis is based on the use of a hypertonic solution for treatment of donors who are in shock in an attempt to increase the supply of lungs for transplantation. Methods: A total of 80 rats were allocated to four groups: one group was given an infusion of normal saline (NS; n = 20), one group received HS; n = 20, a sham group (n = 20), and a Shock group (n = 20). Half of the lungs from each group were evaluated in an ex vivo perfusion system, and the other half was used for measurements of cytokine levels and neutrophil counts. Results: In the ex vivo perfusion assessment, the pulmonary artery pressures of the animals in the NS and HS groups did not exhibit significant differences compared with those in the sham group (P > 0.05) but were lower than those in the Shock group (P < 0.01). Furthermore, the tumor necrosis factor-alpha levels and neutrophil counts were lower in the HS group than those in the Shock group (P < 0.01) and did not exhibit significant differences compared with those in either the NS and Sham groups (P > 0.05). Conclusions: We showed that HS was equivalent to isotonic saline and contributed to the treatment of lungs subjected to hemorrhagic shock.
article 3 Citação(ões) na Scopus Lung Transplantation in Tuberculosis(2018) SAMANO, Marcos N.; FERNANDES, Lucas M.; CAMPOS, Silvia V.; PEGO-FERNANDES, Paulo M.