RAFAEL CAPARICA BITTON

Índice h a partir de 2011
4
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ICESP-OS, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina

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Assunto: lung cancer ×

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  • article 33 Citação(ões) na Scopus
    The potential of neurotrophic tyrosine kinase (NTRK) inhibitors for treating lung cancer
    (2016) PASSIGLIA, Francesco; CAPARICA, Rafael; GIOVANNETTI, Elisa; GIALLOMBARDO, Marco; LISTI, Angela; DIANA, Patrizia; CIRRINCIONE, Girolamo; CAGLEVIC, Christian; RAEZ, Luis E.; RUSSO, Antonio; ROLFO, Christian
    Introduction: Molecular alterations in neurotrophic tyrosine kinase (NTRK) genes have been identified in several solid tumors including lung cancer. Pre-clinical and clinical evidence suggested their potential role as oncogenic drivers and predictive biomarkers for targeted inhibition, leading to the clinical development of a new class of compounds blocking the NTRK molecular pathway, which are currently undner early clinical investigation. Area covered: This review describes the biology of the NTRK pathway and its molecular alterations in lung cancer. It focuses on the pre-clinical and clinical development of emerging NTRK inhibitors, which have shown very promising activity in early phase I studies. Expert opinion: Among the several NTRK-inhibitors, entrectinib and LOXO-101 are those in more advanced stage of clinical development. Both agents have shown encouraging activity along with a tolerable safety profile in patients with different solid tumors harboring NTRK-fusions, emerging as new promising therapeutic options for molecularly selected patients with advanced Trk-driven lung cancers. Results from ongoing phase II basket trials are eagerly awaited.
  • conferenceObject
    Validating ECOG Performance Status as a Prognostic Factor in Brazilian Patients with Pulmonary Adenocarcinoma
    (2015) BITTON, Rafael C.; LIMA, Luiz G. C. A. De; ROITBERG, Felipe S. R.; MESQUITA, Cristiane; MARTINS, Renata E.; YEN, Cheng T.; TERRA, Ricardo M.; MELLO, Evandro S.; CASTRO JR., Gilberto De