LUIZA GUILHERME GUGLIELMI
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
2 resultados
Resultados de Busca
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- Analysis of the coverage capacity of the StreptInCor candidate vaccine against Streptococcus pyogenes(2014) AMICIS, Karine M. De; BARROS, Samar Freschi de; ALENCAR, Raquel E.; POSTOL, Edilberto; MARTINS, Carlo de Oliveira; ARCURI, Helen Andrade; GOULART, Cibelly; KALIL, Jorge; GUILHERME, LuizaStreptococcus pyogenes is responsible for infections as pharyngitis, sepsis, necrotizing fasciitis and streptococcal toxic shock syndrome. The M protein is the major bacterial antigen and consists of both polymorphic N-terminal portion and a conserved region. In the present study, we analyzed the in vitro ability of StreptInCor a C-terminal candidate vaccine against S. pyogenes to induce antibodies to neutralize/opsonize the most common S. pyogenes strains in Sao Paulo by examining the recognition by sera from StreptInCor immunized mice. We also evaluated the presence of cross-reactive antibodies against human heart valve tissue. Anti-StreptInCor antibodies were able to neutralize/opsonize at least 5 strains, showing that immunization with StreptInCor is effective against several S. pyogenes strains and can prevent infection and subsequent sequelae without causing autoimmune reactions.
- Rheumatic Fever and Rheumatic Heart Disease(2014) GUILHERME, L.; KALIL, J.Rheumatic heart disease is a sequel of rheumatic fever that follows an untreated group A streptococcal infection of young susceptible individuals. The disease is mediated by inflammatory and autoimmune reactions. Several genes related to both innate and adaptive immune responses are involved and HLA class II alleles have also been associated with the disease. Both cellular and humoral immune responses take part in the autoimmune reactions, in which Th1 and Th17 inflammatory cytokines are mediators of the rheumatic heart lesions. Since humans are unique hosts for S. pyogenes infections, several studies have been done to find a suitable animal model in numerous different species including mice, rats, hamsters, rabbits, and primates. The in vitro analysis of heart tissue infiltrating T cells showed their ability to recognize several streptococcal-M protein peptides as well as self antigens by molecular mimicry mechanisms and demonstrated the contribution of CD4+ T cells in the pathogenesis of the disease.