LUIZA GUILHERME GUGLIELMI
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina - Líder
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Acute rheumatic fever and rheumatic heart disease(2016) CARAPETIS, Jonathan R.; BEATON, Andrea; CUNNINGHAM, Madeleine W.; GUILHERME, Luiza; KARTHIKEYAN, Canesan; MAYOSI, Bongani M.; SABLE, Craig; STEER, Andrew; WILSON, Nigel; WYBER, Rosemary; ZUHLKE, LiesAcute rheumatic fever (ARE) is the result of an autoimmune response to pharyngitis caused by infection with group A Streptococcus. The long-term damage to cardiac valves caused by ARF, which can result from a single severe episode or from multiple recurrent episodes of the illness, is known as rheumatic heart disease (RHD) and is a notable cause of morbidity and mortality in resource-poor settings around the world. Although our understanding of disease pathogenesis has advanced in recent years, this has not led to dramatic improvements in diagnostic approaches, which are still reliant on clinical features using the Jones Criteria, or treatment practices. Indeed, penicillin has been the mainstay of treatment for decades and there is no other treatment that has been proven to alter the Likelihood or the severity of RHD after an episode of ARE. Recent advances including the use of echocardiographic diagnosis in those with ARF and in screening for early detection of RHD, progress in developing group A streptococcal vaccines and an increased focus on the Lived experience of those with RHD and the need to improve quality of life give cause for optimism that progress will be made in coming years against this neglected disease that affects populations around the world, but is a particular issue for those Living in poverty.
- Rheumatic Fever: a neglected and underdiagnosed disease. New perspective on diagnosis and prevention(2016) BRANCO, Carlos Eduardo de Barros; SAMPAIO, Roney Orismar; BRACCO, Mario Maia; MORHY, Samira Saady; VIEIRA, Marcelo Luiz Campos; GUILHERME, Luiza; RIZZO, Luiz Vicente; TARASOUTCH, Flavio
- Status of research and development of vaccines for Streptococcus pyogenes(2016) STEER, Andrew C.; CARAPETIS, Jonathan R.; DALE, James B.; FRASER, John D.; GOOD, Michael F.; GUILHERME, Luiza; MORELAND, Nicole J.; MULHOLLAND, E. Kim; SCHODEL, Florian; SMEESTERS, Pierre R.Streptococcus pyogenes is an important global pathogen, causing considerable morbidity and mortality, especially in low and middle income countries where rheumatic heart disease and invasive infections are common. There is a number of promising vaccine candidates, most notably those based on the M protein, the key virulence factor for the bacterium. Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates. (C) 2016 World Health Organization; licensee Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.orgilicensesiby/3.0/).