LUIZA GUILHERME GUGLIELMI

(Fonte: Lattes)
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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular, Hospital das Clínicas, Faculdade de Medicina - Líder

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  • article 12 Citação(ões) na Scopus
    Group A Streptococcus Adsorbed Vaccine: Repeated Intramuscular Dose Toxicity Test in Minipigs
    (2019) POSTOL, Edilberto; SA-ROCHA, Luiz C.; SAMPAIO, Roney O.; DERNARCHI, Lea M. M. F.; ALENCAR, Raquel E.; ABDUCH, Maria C. D.; KALIL, Jorge; GUILHERME, Luiza
    Streptococcus pyogenes infection continues to be a worldwide public health problem causing various diseases in humans and plays an important role in the pathogenesis of rheumatic fever and rheumatic heart disease. We developed a vaccine candidate to prevent S. pyogenes infections, identified as StreptInCor, that presented promising results in mouse models. A certified and independent laboratory conducted two repeated intramuscular dose toxicity tests (28 days, four weekly injections). The first test, composed of four experimental groups treated with 0 (vehicle), 50, 100 or 200 mu g/500 mu L StreptInCor, did not show significant alterations in clinical, hematological, biochemical or anatomopathologica I parameters related to the administration of StreptInCor. In addition to the parameters mentioned above, we evaluated the cardiac function and valves of animals by echocardiography before and after administration of 200 mu g/500 mu L StreptInCor versus placebo. We did not observe any changes related to StreptInCor administration, including changes in cardiac function and valves in animals, after receiving the highest dose of this vaccine candidate. The results obtained in the two repeated intramuscular dose toxicity tests showed that this vaccine formulation did not induce harmful effects to the tissues and organs studied, indicating that the candidate vaccine is well tolerated in minipigs.
  • bookPart 0 Citação(ões) na Scopus
    Rheumatic fever and rheumatic heart disease
    (2019) GUILHERME, L.; KALIL, J.
    Rheumatic heart disease is a sequel of rheumatic fever that follows an untreated group A streptococcal infection of young susceptible individuals. The disease is mediated by inflammatory and autoimmune reactions. Several genes related to both innate and adaptive immune responses are involved. Human leukocytes antigens class II alleles have been associated with the disease. Both cellular and humoral immune responses are involved with the autoimmune reactions, and Th1 and Th17 inflammatory cytokines are the mediators of rheumatic heart lesions. Although humans are unique hosts for Streptococcus pyogenes infections, several studies have been done to find a suitable animal model and numerous different species (mice, rats, hamsters, rabbits, and primates). The in vitro analysis of tissue-infiltrating T cells showed their ability of recognizing several streptococcal-M protein peptides and self-antigens by molecular mimicry mechanism and demonstrated the involvement of CD4+ T cells in the pathogenesis of the disease. © 2020 Elsevier Inc. All rights reserved.