HELOISA DE ANDRADE CARVALHO
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina - Médico
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- An Observational Study of the Prognosis of Inpatients Evaluated for Palliative Radiation Therapy(2018) SR., A. T. C. Chen; MAURO, G. P.; GABRIELLI, F.; CHAVES, C.; CASTRO, I.; VASCONCELOS, K.; SARAIVA, T.; REIS, M.; CARVALHO, H. D. A.
- Brazil's Challenges and Opportunities(2015) MORAES, Fabio Ynoe de; MARTA, Gustavo Nader; HANNA, Samir Abdallah; LEITE, Elton Trigo Teixeira; FERRIGNO, Robson; SILVA, Joao Luis Fernandes da; CARVALHO, Heloisa de Andrade
conferenceObject Trial Sponsorship, Self Reported Conflicts of Interest of Authors (COI) and Non-Drug Related Randomized Clinical Trial (rRCT) in Prostate Cancer(2014) MORAES, F.; LEITE, E.; SANTINI, F.; MARTA, G.; HANNA, S.; SILVA, J.; CARVALHO, H.- Brazil's Challenges and Opportunities Reply(2015) MORAES, Fabio Ynoe de; MARTA, Gustavo Nader; HANNA, Samir Abdallah; LEITE, Elton Trigo Teixiera; FERRIGNO, Robson; SILVA, Joao Luis Fernandes da; CARVALHO, Heloisa de Andrade
- Intraoperative Radiation Therapy in Early Breast Cancer Using a Linear Accelerator Outside of the Operative Suite: An ""Image-Guided"" Approach(2014) HANNA, Samir Abdallah; BARROS, Alfredo Carlos Simoes Dornellas de; ANDRADE, Felipe Eduardo Martins de; BEVILACQUA, Jose Luiz Barbosa; PIATO, Jose Roberto Morales; PELOSI, Edilson Lopes; MARTELLA, Eduardo; SILVA, Joao Luis Fernandes da; CARVALHO, Heloisa de AndradePurpose: To present local control, complications, and cosmetic outcomes of intraoperative radiation therapy (IORT) for early breast cancer, as well as technical aspects related to the use of a nondedicated linear accelerator. Methods and Materials: This prospective trial began in May of 2004. Eligibility criteria were biopsy-proven breast-infiltrating ductal carcinoma, age >40 years, tumor <3 cm, and cN0. Exclusion criteria were in situ or lobular types, multicentricity, skin invasion, any contraindication for surgery and/or radiation therapy, sentinel lymph node involvement, metastasis, or another malignancy. Patients underwent classic quadrantectomy with intraoperative sentinel lymph node and margins evaluation. If both free, the patient was transferred from operative suite to linear accelerator room, and IORT was delivered (21 Gy). Primary endpoint: local recurrence (LR); secondary endpoints: toxicities and aesthetics. Quality assurance involved using a customized shield for chest wall protection, applying procedures to minimize infection caused by patient transportation, and using portal films to check collimator-shield alignment. Results: A total of 152 patients were included, with at least 1 year follow-up. Median age (range) was 58.3 (40-85.4) years, and median follow-up time was 50.7 (12-110.5) months. The likelihood of 5-year local recurrence was 3.7%. There were 3 deaths, 2 of which were cancer related. The Kaplan-Meier 5-year actuarial estimates of overall, disease-free, and local recurrence-free survivals were 97.8%, 92.5%, and 96.3%, respectively. The overall incidences of acute and late toxicities were 12.5% and 29.6%, respectively. Excellent, good, fair, and bad cosmetic results were observed in 76.9%, 15.8%, 4.3%, and 2.8% of patients, respectively. Most treatments were performed with a 5-cm collimator, and in 39.8% of the patients the electron-beam energy used was >= 12 MeV. All patients underwent portal film evaluation, and the shielding was repositioned in 39.9% of cases. No infection or anesthesia complications were observed. Conclusions: Local control with IORT was adequate, with low complication rates and good cosmetic outcomes. More than one-third of patients benefited from the ""image-guidance"" approach, and almost 40% benefited from the option of higher electron beam energies. (C) 2014 Elsevier Inc.
- Bone Event: A New Surrogate to Solitary Plasmacytoma(2018) MAURO, G. P.; CARVALHO, H. D. A.; NEFFA, P.; MARTINEZ, G. A.; VILLAR, R. C.