RICARDO FERREIRA BENTO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Otorrinolaringologia e Oftalmologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina - Líder
4 resultados
Resultados de Busca
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- Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study(2023) DAMIANO, Rodolfo Furlan; NETO, Deusdedit Brandao; OLIVEIRA, Joao Vitor Ribeiro; SANTOS, Jonatas Magalhaes; ALVES, Julia Vallin Rodrigues; GUEDES, Bruno F.; NITRINI, Ricardo; ARAUJO, Adriana Ladeira de; OLIVEIRA, Melaine; BRUNONI, Andre R.; VOEGELS, Richard Louis; BENTO, Ricardo Ferreira; BUSATTO, Geraldo; MIGUEL, Euripedes Constantino; FORLENZA, Orestes V.; PINNA, Fabio de RezendePreliminary methodologically limited studies suggested that taste and smell known as chemosensory impairments and neuropsychiatric symptoms are associated in post-COVID-19. The objective of this study is to evaluate whether chemosensory dysfunction and neuropsychiatric impairments in a well-characterized post-COVID-19 sample. This is a cohort study assessing adult patients hospitalized due to moderate or severe forms of COVID-19 between March and August 2020. Baseline information includes several clinical and hospitalization data. Further evaluations were made using several different reliable instruments designed to assess taste and smell functions, parosmia, and neuropsychiatric disorders (using standardized psychiatric and cognitive measures). Out of 1800 eligible individuals, 701 volunteers were assessed on this study. After multivariate analysis, patients reporting parosmia had a worse perception of memory performance (p < 0.001). Moderate/severe hypogeusia was significantly associated with a worse performance on the word list memory task (p = 0.012); Concomitant moderate/severe olfactory and gustatory loss during the acute phase of COVID-19 was also significantly associated with episodic memory impairment (p = 0.006). We found a positive association between reported chemosensory (taste and olfaction) abnormalities and cognition dysfunction in post-COVID-19 patients. These findings may help us identify potential mechanisms linking these two neurobiological functions, and also support the speculation on a possible route through which SARS-CoV-2 may reach the central nervous system.
- A three-dimensionally printed otological model for cholesteatoma mastoidectomy training(2023) SOUZA, Marcos Antonio de; BENTO, Ricardo Ferreira; LOPES, Paula TardimPurpose To relate the creation and expert validation (face and content validity) of an affordable three-dimensional (3-D) printed model of temporal bones with chronic otitis media with cholesteatoma (COMC) as a simulator for mastoidectomy. Methods We performed computed tomography (CT) of the temporal bones of a patient with COMC followed at the University of Sao Paulo (USP) Hospital with 3-D Slicer to create a 3-D model of the affected bone using light-curing resin and silicone (cholesteatoma). The final 3-D printed images were scored by 10 otologists using a customized version of the Michigan Standard Simulation Scale Experience (MiSSES). Internal consistency and inter-rater reliability were assessed using Cronbach's alpha and intraclass correlations. Results Otologists consistently scored the model positively for fidelity, educational value, reactions, and the overall model quality. Nine otologists agreed that the model was a good educational device for surgical training of COMC. All experts deemed the model ready-or nearly ready-for use. The final cost of the model, including raw materials and manufacturing, was 120 USD. Conclusions Using 3-D printing technology, we created the first anatomically accurate, low-cost, disease-reproducing 3-D model of temporal bones for mastoidectomy training for cholesteatoma.
- Brazilian Society of Otology task force -- Vestibular Schwannoma -- evaluation and treatment(2023) SILVA, Vagner Antonio Rodrigues; LAVINSKY, Joel; PAUNA, Henrique Furlan; VIANNA, Melissa Ferreira; SANTOS, Vanessa Mazanek; IKINO, Claudio Marcio Yudi; SAMPAIO, Andre Luiz Lopes; LOPES, Paula Tardim; LAMOUNIER, Pauliana; MARANHAO, Andre Souza de Albuquerque; SOARES, Vitor Yamashiro Rocha; POLANSKI, Jose Fernando; DENARO, Mariana Moreira de Castro; CHONE, Carlos Takahiro; BENTO, Ricardo Ferreira; CASTILHO, Arthur MeninoObjective: To review the literature on the diagnosis and treatment of vestibular schwannoma. Methods: Task force members were educated on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on vestibular schwannoma were eligible for inclusion. The American College of Physicians' guideline grading system and the American Thyroid Association's guideline criteria were used for critical appraisal of evidence and recommendations for therapeutic interventions. Results: The topics were divided into 2 parts: (1) Diagnosis audiologic, electrophysiologic tests, and imaging; (2) Treatment wait and scan protocols, surgery, radiosurgery/radiotherapy, and systemic therapy. Conclusions: Decision making in VS treatment has become more challenging. MRI can diagnose increasingly smaller tumors, which has disastrous consequences for the patients and their families. It is important to develop an individualized approach for each case, which highly depends on the experience of each surgical team.(c) 2023 Associacao Brasileira de Otorrinolaringologia e Cirurgia C ' ervico-Facial.
- Generation of four induced pluripotent stem cells lines from PBMC of the DFNA58 family members: Two hearing-impaired duplication carriers (USPi006-A e USPi007-A) and two normal-hearing noncarriers (USPi004-A and USPi005-A)(2023) KOBAYASHI, Gerson S.; VIEIRA-SILVA, Gleiciele A.; VARELLA-BRANCO, Elisa; MOREIRA, Danielle P.; KITAJIMA, Joao Paulo F. W.; HEMZA, Claudia R. M. L.; MINGRONI-NETTO, Regina C.; LOJUDICE, Fernando H.; OITICICA, Jeanne; BENTO, Ricardo F.; BATISSOCO, Ana C.; LEZIROVITZ, KarinaThe DFNA58 locus contains a genomic duplication involving three protein-coding genes (CNRIP1, PLEK, and PPP3R1 & PRIME;s exon 1) and other uncharacterized lncRNA genes (LOC101927723, LOC107985892 and LOC102724389). To clarify the role of these genes in hearing and precisely determine their role in hearing loss, four iPSC lines were generated from two carriers and two noncarriers of the duplication.